Vitamin A Intoxication

Chronic Intoxication with Vitamin A in Adults

“…On the other hand, the tendency to haemorrhage which is found in several cases [2,7] was not observed. In agreement with this, the laboratory studies showed th at the coagulability of the blood was unaffected.…”

“…It was first described by Sulzberger and Lazar in 1951, and a further 7 cases have been reported since then [2,7,9,11,23].…”

Isotretinoin and neuropsychiatric side effects: Continued vigilance is needed

“…A number of cases have been reported in the literature of mental symptoms associated with vitamin A toxicity, including irritability, depression, lethargy, mood lability, and psychosis ( Elliott and Dryer, 1956 ; Frame et al, 1974 ; Gerber et al, 1954 ; Morrice et al, 1960 ; Muenter et al, 1971 ; Oliver and Havener, 1958 ; Persson et al, 1965 ; Shaw and Niccoli, 1953 ; Soler-Bechara and Soscia, 1963 ; Sulzberger and Lazar, 1951 ). These symptoms resolve with discontinuation of vitamin A ( Bifulco, 1953 ; Persson et al, 1965 ; Restak, 1972 ; Shaywitz et al, 1977 ; Soler-Bechara and Soscia, 1963 ). For instance, Restak (1972) reported a case of vitamin A toxicity associated with the development of aggression, personality changes, and depression, which resolved with discontinuation.…”