VITAMIN A in RHEUMATIC FEVER

Jacobs, A.L.; Leitner, Z. A.; Moore, Thomas; Sharman, I. M.

doi:10.1093/ajcn/2.3.155

Cited by 18 publications

(4 citation statements)

References 2 publications

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“…Our finding of an association between serum retinol changes and severity of infection was consistent with findings of previous reports (4,6). In infants with respiratory syncytial virus infection, low serum retinol concentrations at the time of diagnosis were associated with more severe illness, as determined by the need for mechanical ventilation (7) and admission to the intensive care unit (30).…”

Section: Discussionsupporting

confidence: 93%

“…This was a transient phenomenon because the serum retinol concentrations of these children increased significantly by the time of discharge without vitamin A supplementation. Low serum retinol has been observed in other diseases and conditions (1,3,4,6,22,23). The transient decrease of serum retinol during infection was characterized in an early study (4), which showed that serum retinol decreased rapidly with the onset of rheumatic fever and slowly recovered over a period of 3-4 wk during convalescence.…”

Section: Discussionmentioning

confidence: 96%

“…Low serum retinol has been observed in other diseases and conditions (1,3,4,6,22,23). The transient decrease of serum retinol during infection was characterized in an early study (4), which showed that serum retinol decreased rapidly with the onset of rheumatic fever and slowly recovered over a period of 3-4 wk during convalescence. In children with measles, it took 8 wk after recovery for normal con- centrations of retinol and RBP to be restored (24).…”

Section: Discussionmentioning

confidence: 96%

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Predictors of serum retinol in children with shigellosis

Mitra

Alvarez

Wahed

et al. 1998

The American Journal of Clinical Nutrition

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Background: Low serum retinol can be useful as an indicator of depleted liver vitamin A stores, particularly in population-based studies. However, serum retinol concentrations decrease transiently during infection, independent of any changes in liver stores. The magnitude of the decrease in serum retinol is often proportional to indicators of disease severity. Objective: We examined the relation of serum retinol in children with culture-positive shigellosis with severity of illness, anthropometric indicators of nutritional status, urinary retinol excretion, and serum concentrations of C-reactive protein, ␣ 1 -acid glycoprotein, retinol binding protein, and transthyretin. Design: This was a prospective study assessing the clinical and laboratory measurements at admission and recovery of 90 children with dysentery (66 with shigellosis) hospitalized in Bangladesh. Results: Serum retinol concentrations were low at admission but were significantly greater at discharge even though no vitamin A supplements were given during the illness (0.36 ± 0.22 compared with 1.15 ± 0.50 mol/L, P < 0.001). Serum retinol concentrations were lower in children with Shigella dysenteriae type 1 infection than in children with shigellosis due to less virulent strains of Shigella. Low serum retinol was independently associated with S. dysenteriae type 1, high serum C-reactive protein concentrations, and low weight-forage in multiple regression analysis. Conclusions: This study showed that shigellosis was associated with a significant, transient decrease in serum retinol concentrations of Ϸ0.8 mol/L, and that this change was significantly associated with severity of disease and poor underlying nutritional status, particularly low weight-for-age.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

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Predictors of serum retinol in children with shigellosis

Mitra

Alvarez

Wahed

et al. 1998

The American Journal of Clinical Nutrition

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“…Investigations of serum and plasma vitamin A levels (52,53) have shown them to be reduced during acute rheumatic fever, but also during pyrexia of any cause, or during periods of poor intake.…”

Section: Rheumatic Fevermentioning

confidence: 99%