Vitamin A homeostasis and diabetes mellitus

Basu, Tapan K.; Basualdo, Carlotta

doi:10.1016/s0899-9007(97)00192-5

Cited by 78 publications

(82 citation statements)

References 23 publications

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“…Similar to those observed in humans, decreased plasma retinol, RBP4, and TTR levels were observed in genetic and STZinduced T1D rat models, with consequent increase in hepatic concentrations when compared with the nondiabetic animals (41,(47)(48)(49)(50). The factors that may affect blood retinol status include its dietary intake, absorption, and the proteins related to the intrahepatic retinol metabolism or transport.…”

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetessupporting

confidence: 67%

“…The factors that may affect blood retinol status include its dietary intake, absorption, and the proteins related to the intrahepatic retinol metabolism or transport. Neither the intake nor the intestinal absorption of vitamin A was found to be affected in T1D (41,50). In fact, the intake of food and hence vitamin A is markedly increased in STZ-induced diabetic rats (41,50).…”

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 87%

“…Furthermore, the low retinol phenotype also appears to be heritable among T1D subjects, suggesting an inherent metabolic link between T1D and vitamin A transport. Basu et al (40,41) also reported declined plasma vitamin A levels in T1D adults. Interestingly, plasma levels of vitamin A in diabetic patients as well as in the control subjects showed a significant linear regression with plasma concentrations of RBP4, suggesting incomplete mobilization from liver stores or increased renal clearance of RBP4 (40,41).…”

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 94%

“…Basu et al (40,41) also reported declined plasma vitamin A levels in T1D adults. Interestingly, plasma levels of vitamin A in diabetic patients as well as in the control subjects showed a significant linear regression with plasma concentrations of RBP4, suggesting incomplete mobilization from liver stores or increased renal clearance of RBP4 (40,41). However, in these subjects, the plasma vitamin E concentrations remained normal, implying specific alterations in the vitamin A transport during T1D (40).…”

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 94%

“…Although plasma retinol and RBP4 levels in plasma of T1D subjects are reduced when compared with their normal counterparts, it did not manifest subclinical vitamin A deficiency (40,41). Alternatively, urinary excretion of both RBP4 and retinol was found to be elevated in T1D subjects even under conditions of normoalbuminurea (45,46), suggesting that increased renal filtration might also account for reduced plasma RBP4/retinol levels ( Fig.…”

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 95%

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Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: The significance of transthyretin

et al. 2012

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SummaryRetinol-binding protein 4 (RBP4) is the principle carrier of retinol in the human plasma, which circulates as a complex with transthyretin (TTR), a homotetrameric thyroxine transport protein. Although this complex formation is thought to prevent glomerular filtration of RBP4, it also stabilizes the quaternary structure of TTR. Recent studies indicate elevated plasma levels of RBP4 in type 2 diabetes (T2D). In contrast, reduced RBP4 levels were observed in type 1 diabetes (T1D). Herein, we critically examine the probable mechanisms involved in the regulation of RBP4 and TTR levels during T2D and T1D. The available evidences point to the involvement of pancreatic factors in regulating the expression of both RBP4 and TTR. It appears that during T1D, TTR levels are reduced and it exists predominantly as a monomer that may interfere its interaction with RBP4 resulting in its loss through glomerular filtration. However, plasma TTR levels remain high under T2D conditions and thus reducing glomerular filtration of RBP4. Therefore, the plasma TTR levels appear to be an important determinant of plasma RBP4 levels in these two diabetic conditions. 2012 IUBMB IUBMB Life, 64(12): 975-982, 2012

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Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetessupporting

confidence: 67%

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 87%

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 94%

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 94%

Section: Plasma Rbp4 Ttr and Retinol Levels In Type 1 Diabetesmentioning

confidence: 95%

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Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: The significance of transthyretin

et al. 2012

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Plasma levels of lipophilic antioxidants in very old patients with Type 2 diabetes

Polidori

Mecocci

Stahl

et al. 2000

Diabetes Metab. Res. Rev.

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Background Experimental research indicates that oxidative stress is implicated in aging and in the pathogenesis of diabetes and its complications. This evidence is limited in elderly patients with non‐insulin dependent diabetes, in which age‐ and disease‐related production of reactive oxygen species might exert synergistic damaging effects on tissues and organs. Methods Plasma levels of lipid‐soluble compounds with antioxidant properties including vitamin A, vitamin E and carotenoids (lutein, zeaxanthin, β‐cryptoxanthin, lycopene, α‐ and β‐carotene) were measured by HPLC in 72 elderly patients with non‐insulin dependent diabetes (75.7±0.8 years, 40 F, 32 M) and in 75 age‐matched controls (77.2±1.2 years, 48 F, 27 M). Results All compounds measured were significantly lower in plasma from diabetic patients as compared to controls (p<0.0001). Plasma levels of vitamins A and E and of carotenoids did not significantly correlate with dietary intake and lipid profile in both groups. In patients, significant inverse correlations were found between age and levels of vitamin E, β‐cryptoxanthin, lycopene and β‐carotene. Conclusions We conclude that patients of very old age with Type 2 diabetes show a poor plasma status of vitamins A and E and carotenoids, which negatively correlates with age. Further studies are needed to explore the possible therapeutic role of lipid‐soluble vitamin supplements in elderly diabetic subjects. Copyright © 2000 John Wiley & Sons, Ltd.

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Expression of ß‐carotene 15,15′‐monooxygenase gene and retinol status in type 2 diabetic Goto‐kakizaki rats

Takitani¹,

Miyazaki²,

Takaya³

et al. 2008

BioFactors

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The vitamin A status has been studied in type 2 diabetes and it is known that plasma retinol levels of patients with type 2 diabetes are elevated. However, the details of vitamin A metabolism in type 2 diabetes are unclear. beta-Carotene exhibits biological activity as provitamin A and beta-carotene 15,15'-monooxygenase (BCM) cleaves beta-carotene to form retinal. We studied BCM gene expression in type 2 diabetic Goto-Kakizaki (GK) rats. BCM gene expression was analyzed in the liver, intestine, and testis of 8- and 13-week-old GK rats and Wistar rats (control). The plasma and liver retinol levels were measured, and plasma retinol-binding protein (RBP) was detected. BCM gene expression in the liver, intestine and testis of GK rats was increased compared with that in controls. Plasma retinol levels and RBP levels were increased in GK rats, but hepatic retinol levels did not differ between GK rats and controls. BCM gene expression in the liver and intestine might affect retinol levels in type 2 diabetes. Conversion of beta-carotene to retinal might be accelerated in the presence of insulin resistance status, so that plasma retinol levels are increased in type 2 diabetes.

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Vitamin A homeostasis and diabetes mellitus

Cited by 78 publications

References 23 publications

Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: The significance of transthyretin

Contrasting effects of type 2 and type 1 diabetes on plasma RBP4 levels: The significance of transthyretin

Plasma levels of lipophilic antioxidants in very old patients with Type 2 diabetes

Expression of ß‐carotene 15,15′‐monooxygenase gene and retinol status in type 2 diabetic Goto‐kakizaki rats

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