Vitamin A deficiency suppresses high fructose-induced triglyceride synthesis and elevates resolvin D1 levels

Reddy, Mooli Raja Gopal; Chodisetti, Pavan Kumar; Mahesh, Malleswarapu; Kumar, Manchiryala Sravan; Venkata, Surekha Mullapudi; Putcha, Uday Kumar; Vajreswari, Ayyalasomayajula; Jeyakumar, Shanmugam M.

doi:10.1016/j.bbalip.2015.11.005

Cited by 19 publications

(39 citation statements)

References 24 publications

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“…20 Thus, the role of adipose tissue-mediated changes on the progression of steatosis is not apparent. Although some of these inflammatory adipocytokines levels in plasma were not quantified in the present study, our previous report has revealed unaltered plasma TNF-α levels, and the absence of hepatic inflammation or infiltration of inflammatory cells in the liver of highfructose diet-fed rats, however, did find hepatic steatosis/triglyceride accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…20 Further, at the end of 16-week period, the circulatory retinol levels significantly lowered (approximately 95%) in animals receiving vitamin A-deficient diet (C-VAD and HFr-VAD), compared with the control or HFr diet-fed groups (Table 1). Although absolute RPWAT weight of the HFr group was found significantly lower than that of the control, it was comparable, after adjusting to the body weight.…”

Section: Vitamin a Deficiency Attenuated The High-fructose-induced mentioning

confidence: 94%

“…Although absolute RPWAT weight of the HFr group was found significantly lower than that of the control, it was comparable, after adjusting to the body weight. 20 To understand the impact of dietary modifications on adipose tissue biology, the major visceral adipose depot, RPWAT, was used for all the subsequent analyses. 20 Further, at the end of 16-week period, the circulatory retinol levels significantly lowered (approximately 95%) in animals receiving vitamin A-deficient diet (C-VAD and HFr-VAD), compared with the control or HFr diet-fed groups (Table 1).…”

Section: Vitamin a Deficiency Attenuated The High-fructose-induced mentioning

confidence: 99%

“…5 Unlike glucose (aldo-sugar), fructose (keto-sugar) catabolism has no regulatory enzyme, and therefore, during the excessive influx of fructose, it undergoes uncontrolled catabolism in liver, resulting in hepatic triglyceride accumulation. [17][18][19][20] Despite the fact that both these dietary factors, ie, fructose and vitamin A, influence the adipose tissue, until now, no studies have envisaged the effect of high-fructose consumption sans of vitamin A on adipose tissue metabolism. 6 Various epidemiological and clinical studies have reported that among the refined sugars, highfructose consumption in the form of high-fructose corn syrup (HFCS) through carbonated/sweetened beverages is positively associated with increased risk for various metabolic diseases such as obesity, insulin resistance, metabolic syndrome, and non-alcoholic fatty liver.…”

mentioning

confidence: 99%

“…Therefore, fructose is termed as a lipogenic sugar. 20 [7][8][9] Further, some studies have also found increased adiposity and triglyceride accumulation due to high-fructose consumption.…”

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confidence: 99%

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Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Reddy

Mahesh

Munikumar

et al. 2019

Cell Biochemistry & Function

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Here, we tested a hypothesis that vitamin A and/or its metabolic pathways are involved in the high-fructose-mediated alteration in adipose tissue biology. For this purpose, weanling male Wistar rats were provided with one of the following diets: control (C), control with vitamin A deficiency (C-VAD), high fructose (HFr), and HFr with VAD (HFr-VAD) for 16 weeks, except that half of the C-VAD diet-fed rats were shifted to HFr diet (C-VAD(s)HFr), after 8-week period. Compared with control, feeding of HFr diet significantly increased the triglyceride content (P ≤ .01) and thus adipocyte size (hypertrophy) (P ≤ .001) in visceral adipose depot; retroperitoneal white adipose tissue (RPWAT) and these changes were corroborated with de novo lipogenesis, as evidenced by the increased glycerol-3-phosphate dehydrogenase activity (P ≤ .01) and up-regulation of lipogenic pathway transcripts, fructose transporter, and aldehyde dehydrogenase 1 A1. On the contrary, the absence of vitamin A in the HFr diet (HFr-VAD) failed to exert these changes; however, it induced adipocyte hyperplasia. Further, vitamin A deficiency-mediated changes were reversed by replenishment, as evident from the group that was shifted from C-VAD to HFr diet.In conclusion, vitamin A and its metabolic pathway play a key determinant role in the high-fructose-induced triglyceride accumulation and adipocyte hypertrophy of visceral white adipose depot.Significance of the study: Here, we report the metabolic impact of high-fructose feeding under vitamin A-sufficient and vitamin A-deficient conditions. Feeding of high-fructose diet induced triglyceride accumulation and adipocyte hypertrophy of the visceral white adipose depots. These changes corroborated with augmented expression of vitamin A and lipid metabolic pathway genes. Contrarily, absence of vitamin A in the high-fructose diet did not elicit such responses, while vitamin A

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Section: Discussionmentioning

confidence: 99%

Section: Vitamin a Deficiency Attenuated The High-fructose-induced mentioning

confidence: 94%

Section: Vitamin a Deficiency Attenuated The High-fructose-induced mentioning

confidence: 99%

mentioning

confidence: 99%

“…Therefore, fructose is termed as a lipogenic sugar. 20 [7][8][9] Further, some studies have also found increased adiposity and triglyceride accumulation due to high-fructose consumption.…”

mentioning

confidence: 99%

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Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Reddy

Mahesh

Munikumar

et al. 2019

Cell Biochemistry & Function

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Carrot juice ingestion attenuates high fructose‐induced circulatory pro‐inflammatory mediators in weanling Wistar rats

et al. 2016

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Dietary and plasma retinoids are not associated with fatty acid desaturase indices in healthy young adults

Hatherell,

Abdelmagid,

et al. 2023

Lipids

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Past research in rodents suggests that fatty acid (FA) desaturase expression and activity may be modified by vitamin A; however, this has not been investigated in humans. The primary objective of this study was to examine associations between dietary retinoid intakes, plasma retinoid concentrations, and FA desaturase indices in young adults. As a secondary objective, biological sex and estrogen‐containing contraceptive (EC) use were investigated due to prior evidence demonstrating that both can influence plasma retinol concentration and FA desaturase indices. Dietary retinoid intake (food frequency questionnaire), plasma retinoid concentrations (high‐performance liquid chromatography–tandem mass spectrometry), plasma FA (gas chromatography), and FA desaturase indices (product‐to‐precursor ratios) from 945 adults recruited for the cross‐sectional Toronto Nutrigenomics and Health study were analyzed. Participants were stratified into quartiles based on plasma retinol concentration and data analyzed by one‐way analysis of covariance. Dietary retinoid intakes were not associated with the overall n‐3 pathway, overall n‐6 pathway, delta‐5 desaturase, delta‐6 desaturase, or delta‐9 desaturase indices (all r < 0.10, p > 0.05). The overall n‐6 pathway index was significantly higher (p = 0.0004) and the delta‐5 desaturase index was significantly lower (p = 0.0003) in individuals with higher plasma retinol levels; however, these differences were lost when participants were grouped by biological sex and EC use. Although weak relationships were observed between plasma retinol and some FA desaturase indices in the total population, these associations appear to be driven by biological sex and EC usage rather than retinoids. We therefore find little evidence of a relationship between retinoids and FA desaturase indices in young, healthy adults.

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Vitamin A deficiency suppresses high fructose-induced triglyceride synthesis and elevates resolvin D1 levels

Cited by 19 publications

References 24 publications

Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Carrot juice ingestion attenuates high fructose‐induced circulatory pro‐inflammatory mediators in weanling Wistar rats

Dietary and plasma retinoids are not associated with fatty acid desaturase indices in healthy young adults

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