Vitamin A Deficiency Phrynoderma Associated with Chronic Giardiasis

Girard, C.; Dereure, O.; Blatiere, Véronique; Guillot, B.; Bessis, Didier

doi:10.1111/j.1525-1470.2006.00261.x

Cited by 51 publications

(26 citation statements)

References 12 publications

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“…31,32 Furthermore, a case of VAD phrynoderma (a rare form of follicular hyperkeratosis associated with deficiencies in vitamins A or C or essential fatty acids) has been reported to be associated with chronic giardiasis in a six-year-old boy in France. 34 In contrast, previous reports from Brazil and Kenya found no association between intestinal parasitic infections and low serum retinol concentrations. 8,28 Moreover, a study aimed at investigating the effects of ascariasis on vitamin A in 24 children 4-10 years of age in a slum area of Dhaka City, Bangladesh, concluded that there was no association between ascariasis and malabsorption of vitamin A.…”

Section: Discussioncontrasting

confidence: 49%

Giardiasis and Poor Vitamin A Status among Aboriginal School Children in Rural Malaysia

Al-Mekhlafi¹,

Surin²,

Sallam³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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Abstract.A cross-sectional study was carried out on 241 primary schoolchildren in Pahang, Malaysia to update their vitamin A status and to investigate the association of poor vitamin A status with their health and socioeconomic factors. All children were screened for intestinal parasitic infections. Blood samples were collected and vitamin A status was assessed. Socioeconomic data were collected by using pre-tested questionnaires. The results showed that 66 (27.4%) children had low serum retinol levels (< 0.70 μmol/L). Giardiasis and severe ascariasis were significantly associated with low serum retinol levels ( P = 0.004 and P = 0.018, respectively). Logistic regression confirmed the significant association of giardiasis with low serum retinol (odds ratio = 2.7, 95% confidence interval = 1.3-5.5). In conclusion, vitamin A deficiency is still a public health problem in rural Malaysia. Vitamin A supplementation and treatment of intestinal parasitic infections should be distributed periodically to these children to improve their health and nutritional status. 18 Iintensity of infection was graded as heavy, moderate, or light according to criteria proposed by the World Health Organization.19 Scores for intensity of infections were given to each soil-transmitted helminth species (light = 1, mild = 2, and severe = 3) and mixed infections with a worm score ≥ 5 were included in the analysis. Samples were also examined for Giardia duodenalis trophozoites or cysts by using the trichrome staining technique.Assessment of vitamin A status. Approximately 2-3 mL of venous blood were collected from each participant into tubes for biochemical analysis. Blood was left at room temperature to ensure clot formation. The tubes were then centrifuged at 3,000 rpm for 10 minutes to obtain serum that was stored at -20°C until further analysis. Serum retinol concentrations were determined using a reverse-phase high performance liquid chromatography (LC-10AD; Shimadzu, Kyoto, Japan) as described. 16,20 One hundred microliters of ethanol containing retinyl acetate as an internal standard was added to 100 μL of serum. Refiltered petroleum ether (RPE) (500 μL) was added and the mixture was mixed with a vortex mixer for 1 minute and centrifuged at 5,000 rpm for 10 minutes. A 150-μL sample from the refiltered petroleum ether layer was transferred into a clean test tube and evaporated. The extract was dissolved in 200 μL of ethanol. Eighty microliters of this mixture was injected into the high performance liquid chromatography apparatus. Methanol:water (95:5 [v/v]) was used as the mobile phase and all-trans retinol was used as the standard. For quality control, 20% of the samples were randomly selected and examined in duplicate. Serum retinol was measured in picomoles per liter.Use of serum retinol to assess vitamin A status may be influenced by inflammation and reductions in plasma retinol, which have been described during the acute phase of a wide range of infections. 21 The design of this study did not consider the inflammatory status of the...

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Section: Discussioncontrasting

confidence: 49%

Giardiasis and Poor Vitamin A Status among Aboriginal School Children in Rural Malaysia

Al-Mekhlafi¹,

Surin²,

Sallam³

et al. 2010

The American Society of Tropical Medicine and Hygiene

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“…Patient 1, a 16-year-old boy, was previously reported as having phrynoderma, an alleged acquired form of follicular hyperkeratosis (figure 1Ba, b) caused by vitamin A deficiency 13. Since he was 2 years old, he had had skin lesions (figure 1Ba–d) and chronic lesions including human papillomavirus (HPV)-like lesions on the larynx (see below) that suggested HPV infections but without any serological conversion.…”

Section: Resultsmentioning

confidence: 99%

A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis)

et al. 2016

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“…It is distinct from 46 Trichodysplasia of immunosuppression 48 Viral-associated trichodysplasia spinulosa Pilomatrix dysplasia Cyclosporine-induced folliculodystrophy Spiny keratoderma 26,29,31,32 Punctate porokeratotic keratoderma 22,23,25,28 Music box spine dermatosis Multiple minute palmar-plantar digitate hyperkeratosis 24 Filiform hyperkeratosis 27,30 MMDH, Multiple minute digitate hyperkeratosis.…”

Section: Discussionmentioning

confidence: 98%

Multiple minute digitate hyperkeratosis: A proposed algorithm for the digitate keratoses

Caccetta

Dessauvagie

McCallum

et al. 2012

Journal of the American Academy of Dermatology

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Vitamin A Deficiency Phrynoderma Associated with Chronic Giardiasis

Cited by 51 publications

References 12 publications

Giardiasis and Poor Vitamin A Status among Aboriginal School Children in Rural Malaysia

Giardiasis and Poor Vitamin A Status among Aboriginal School Children in Rural Malaysia

A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis)

Multiple minute digitate hyperkeratosis: A proposed algorithm for the digitate keratoses

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