Vitamin A and β-Carotene Levels During Pregnancy in Gaziantep, Turkey

Meram, İclal; Bozkurt, Ali; Kilinçer, Şahin; Özçırpıcı, Birgül; Özgür, Servet

doi:10.14712/18059694.2018.90

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…The systolic blood pressure, diastolic blood pressure and mean pressure were significantly raised in subjects with pre-eclampsia compared to normal pregnant and non-pregnant women. But no significant difference was observed between normal pregnant and non-pregnant women which is supported by several studies 2,4,7,12,14 . This study showed increased level of serum copper in pregnancy compared to non-pregnant women which is in agreement with a Turkish study conducted in their population 19 . The physiological importance of these changes remains obscure.…”

Section: Meansupporting

confidence: 92%

Status of Serum Copper and Zinc in Pre-Eclampsia

Muna

Sirazi

Majumder

et al. 2017

Bangladesh J Med Biochem

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Pre-eclampsia is a multisystem and multifactorial disease that affects both mother and fetus by endothelial dysfunction and intrauterine growth retardation. It is thought that pre-eclampsia is associated with an imbalance of increased lipid peroxides and decreased antioxidants. Dietary deficiency or excess of copper, zinc or other micronutrients play important role in the pathogenesis of pre-eclampsia because nutrients can modulate oxidative stress by increasing or decreasing free radicals or antioxidants and providing substrates for formation of free radicals.This study was carried out in the Department of Biochemistry, Sylhet MAG Osmani Medical College during the period from July 2014 to June 2015 to evaluate the status of serum copper and zinc in pre-eclamptic patients. For this study 85 age-matched women were selected and grouped as 30 pre-eclamptic patients, 27 normal pregnant and 28 nonpregnant women. serum copper and zinc level were measured in all study subjects by AAS. Data were analyzed with the help of SPSS version 17.0. Mean (±SD) level of serum copper and zinc were 1.43±0.49 mg/l and 2.43±2.89 mg/l in pre-eclamptics, while in normal pregnant women the levels were 1.51±0.47 mg/l and 2.87±2.23 mg/l and in non-pregnant women these were 0.85±0.28 mg/l and 3.70±2.61 mg/l respectively. Serum copper significantly increased in pre-eclamptics and normal pregnant women when compared with that of non-pregnant women [F (2, 82) =19.763; p<0.001], but there was no significant difference between pre-eclamptic and normal pregnant group. No significant difference of serum zinc among three groups were observed [F (2, 82) =1.774; p=0.176]. The study showed increased trend of serum copper and decreased trend of serum zinc in pregnancy (both preeclampsia and without pre-eclampsia) compared with non-pregnant women, and both were reduced in pre-eclampsia compared to normal pregnancy. As our study did not show any significant difference in copper and zinc level in pre-eclamptics and normal pregnant women hence it can be concluded that there may not be any significant association of serum copper and zinc level with pre-eclampsia.Bangladesh J Med Biochem 2015; 8(2): 49-54

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Section: Meansupporting

confidence: 92%

Status of Serum Copper and Zinc in Pre-Eclampsia

Muna

Sirazi

Majumder

et al. 2017

Bangladesh J Med Biochem

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“…Parallel findings were reported in Zimbabwe (31), India (32), and Turkey (33). In the current study, serum retinol significantly declined by about 22% from the first (0.97 µmol/L) to the third trimester (0.76 µmol/L).…”

Section: Discussionsupporting

confidence: 80%

Prevalence and Correlates of Prenatal Vitamin A Deficiency in Rural Sidama, Southern Ethiopia

Gebreselassie

Gase

Deressa

2013

J Health Popul Nutr

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A cross-sectional study was conducted to assess the prevalence and correlates of prenatal vitamin A deficiency (VAD) in rural Sidama, Southern Ethiopia. Seven hundred randomly-selected pregnant women took part in the study. Serum retinol concentration was determined using high-performance liquid chromatography. Data were analyzed by logistic and linear regression. Interpretation of data was made using adjusted odds ratio (AOR) and adjusted linear regression coefficient. The prevalence of VAD (serum retinol <0.7 µmol/L) was 37.9%. Advanced gestational age and elevated C-reactive protein (CRP ≥5 mg/dL) were negatively associated with retinol concentration (p<0.05). The odds of VAD was significantly higher among the women with no education and those devoid of self-income. Women aged 35-49 years had 2.23 (95% CI 1.31-3.81) times higher odds compared to those aged 15-24 years. The lower the dietary diversity score in the preceding day of the survey, the higher were the odds of VAD. With reference to nulliparas, grand multiparas had 1.92 (95% CI 1.02-3.64) times increased odds of VAD. VAD and zinc deficiency (serum zinc <8.6 µmol/L during the first trimester, or <7.6 µmol/L during the second or third trimester) were significantly associated with AOR of 1.80 (95% CI 1.28-2.53). VAD has major public-health significance in the area. Accordingly, it should be combated through enhancement of diet diversity, birth control, and socioeconomic empowerment of women.

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“…This does not necessarily mean that there is a biological reason for the similar Cu levels observed in the aforementioned study populations; it is merely interesting to note that both populations are from African ethnicity. The mean Cu serum concentration of 2451 µg/L in our study is quite similar to that found in a study on pregnant women in Turkey (2206.7 µg/L) [53] but the range in our study (1157 to 4281 µg/L) differs markedly from the range in a study in Spain (936 to 2304 µg/L) [54].…”

Section: Discussionsupporting

confidence: 86%

In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern

Röllin

Channa

Olutola

et al. 2020

IJERPH

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Aluminium (Al) is a non-essential neurotoxicant and there is limited information regarding exposure to Al in utero. This study sought to evaluate the in utero exposure to Al in urban South African women, its effects on birth outcomes and possible synergistic effects between Al, essential and neurotoxic elements such as lead (Pb), mercury (Hg) and arsenic (As), as well as a a potential sex-dependent response to these elements in neonates. This study has found elevated levels of Al in urban women at delivery. The Spearman’s rank correlation coefficients (p-value) of the association between maternal serum Al and birth outcomes (gestational age and parity), and between maternal serum Al and Cu, Zn and Se, were statistically significant. However, in the general and the stratified models, no association was found between any of the birth outcomes and maternal serum Al. The association between maternal serum Al and neurotoxic elements at delivery showed a significant positive correlation for Pb only (rho = 0.361; p < 0.001) which was found to be sex-dependent in neonates (males, rho = 0.285; p < 0.004 and females, rho = 0.444, p < 0.001). Our preliminary findings indicate that in utero exposure to Al is an emerging concern requiring further research and directives from public health authorities.

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Vitamin A and β-Carotene Levels During Pregnancy in Gaziantep, Turkey

Cited by 9 publications

References 14 publications

Status of Serum Copper and Zinc in Pre-Eclampsia

Status of Serum Copper and Zinc in Pre-Eclampsia

Prevalence and Correlates of Prenatal Vitamin A Deficiency in Rural Sidama, Southern Ethiopia

In Utero Exposure to Aluminium and Other Neurotoxic Elements in Urban Coastal South African Women at Delivery: An Emerging Concern

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