Vitamin A and β-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture

Wolterbeek, A.P.M.; Roggeband, R.; Moorsel, C.J.A. van; Baan, R.A.; Koeman, J.H.; Feron, V.J.; Rutten, A.A.J.J.L.

doi:10.1016/0304-3835(95)03740-n

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…4 Fetal exposure to bioactive compounds in vegetables, fruit, and protein foods such as vitamins and minerals, fiber, peptides and amino acids, and other factors may contribute to the ability of these foods to reduce cancer risk. [21][22][23][24][25][26][27] Using virtually identical data collection methods and independent samples from phases 1 and 2 of the NCCLS to examine the reproducibility of our findings, we found that maternal intake of the vegetables food group and its related component, provitamin A carotenoids, was statistically or borderline-statistically associated with decreased offspring ALL risk in both phases of the study. Thus, the inverse diet-disease relationship appears to be strongest for maternal consumption of the vegetable food group.…”

Section: Discussionmentioning

confidence: 93%

Maternal Diet and Risk of Childhood Acute Lymphoblastic Leukemia

Kwan

Jensen²,

Block³

et al. 2009

Public Health Rep

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Section: Discussionmentioning

confidence: 93%

Maternal Diet and Risk of Childhood Acute Lymphoblastic Leukemia

Kwan

Jensen²,

Block³

et al. 2009

Public Health Rep

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“…45,46) In general, the inhibition of DNAdamage induction by vitamin A is ascribed to an effect on the metabolism of carcinogenic compounds, resulting in a decreased amount of ultimate carcinogen. 41) These effects of β-carotene may also play a role in the chemopreventive action.…”

Section: Discussionmentioning

confidence: 99%

“…39,40) One of the critical events in carcinogenesis is the formation of DNA adducts. 41) Improper DNA repair generates permanent changes via subsequent DNA replication, and vitamin A and β-carotene have been shown to prevent or to decrease DNA damage caused by chemical carcinogens, as detected directly by measuring the level of DNA adducts 42,43) or indirectly by measuring sister-chromatid exchanges, 44) chromosome aberration 38,44) or DNA repair. 45,46) In general, the inhibition of DNAdamage induction by vitamin A is ascribed to an effect on the metabolism of carcinogenic compounds, resulting in a decreased amount of ultimate carcinogen.…”

Section: Discussionmentioning

confidence: 99%

Inhibition by β‐Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure

Furukawa

Nishikawa

Kasahara

et al. 1999

Japanese Journal of Cancer Research

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In recent intervention studies, β β β β-carotene failed to reduce or even increased the incidence of lung cancers in smokers. In the present investigation, the modifying effects of β β β β-carotene at various doses on the development of upper respiratory tract tumors were investigated in Syrian hamsters treated with diethylnitrosamine (DEN) and cigarette smoke. A total of 120 male 5-week-old hamsters were divided into 4 groups, each consisting of 30 animals. After a single subcutaneous (s.c.) injection of 100 mg/kg DEN, hamsters in groups 1-4 were respectively administered diets supplemented with β β β β-carotene at doses of 0.5%, 0.05%, 0.005% or 0% during experimental weeks 1 to 13, and simultaneously exposed to cigarette smoke. The duration of cigarette smoke exposure was 9 min twice a day, 5 days a week. Because of a marked reduction of body weight in group 1, the highest dose of β β β β-carotene was changed to 0.25% after 10 days. In all groups, epithelial hyperplasias and/or papillomas were induced in the larynx and trachea. However, the incidence and multiplicity of papillomas in group 1 were significantly (P< < < <0.05) lower than the group 4 values.Moreover, the β β β β-carotene treatments significantly (P< < < <0.05 or 0.01) reduced both the incidence and multiplicity of hyperplasias in a dose-dependent manner. The levels of retinol and β β β β-carotene in the serum, and the retinol level in the liver, were also elevated with dose dependence. Our results thus indicate that β β β β-carotene inhibits tumorigenesis, even at the high dose of 0.25%, under the present experimental conditions.

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“…Both vitamin A and β-carotene significantly increased benzo(a)pyrene-induced unscheduled DNA synthesis and decreased benzo(a)pyrene-DNA adducts in hamster tracheal epithelium (Wolterbeek, et al, 1995). It was found that SCE level was significantly increased by high doses of vitamin A (10 −5 -10 −4 M) (Alija, et al, 2006), and the enhancement of SCE was restored to its original level by addition of vitamin E (final concentration 2 μg/mL).…”

Section: Introductionmentioning

confidence: 95%

Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B₁ in cultured human lymphocytes

2009

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In this study, we aimed to evaluate the effect of vitamins A, C, and E against aflatoxin B1 (AFB1) on blood cultures in relation to induction of sister chromatid exchange (SCE). The results indicated genotoxic and mutagenic damage in cultured human lymphocytes exposed to AFB1. The results showed that 5 microM concentration of AFB1 increased SCE. When vitamins A, C, and E were added to AFB1, the frequency of SCE decreased. These results suggest that vitamins A, C, and E could effectively inhibit AFB1-induced SCE, which may partially responsible for its mutagenic effect of AFB1. Besides, the protective effect of vitamins A, C, and E against AFB1 was increased in a dose-dependent manner (i.e., as the doses increased, their protective effects also increased). There was a significant decrease in the SCE frequency in AFB1-treated group compared with the groups receiving AFB1 and also vitamins A, C, and E. The most effective concentration was 100 microM vitamin C, and the lowest effective concentration was 0.5 microM vitamin A. Vitamin C has the most effective concentration of 100 microM, and vitamin A has the lowest effective concentration of 0.5 microM. The order of the decreasing effect of the SCE frequency of vitamins was as follows: vitamin C > vitamin E > vitamin A.

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Vitamin A and β-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture

Cited by 17 publications

References 25 publications

Maternal Diet and Risk of Childhood Acute Lymphoblastic Leukemia

Maternal Diet and Risk of Childhood Acute Lymphoblastic Leukemia

Inhibition by β‐Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure

Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B₁ in cultured human lymphocytes

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Vitamin A and β-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture

Cited by 17 publications

References 25 publications

Maternal Diet and Risk of Childhood Acute Lymphoblastic Leukemia

Maternal Diet and Risk of Childhood Acute Lymphoblastic Leukemia

Inhibition by β‐Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure

Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B1 in cultured human lymphocytes

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Product

Resources

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Protective role of vitamins A, C, and E against the genotoxic damage induced by aflatoxin B₁ in cultured human lymphocytes