Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders

Guo, Min; Zhu, Jiang; Yang, Ting; Lai, Xi; Lei, Y Y; Chen, Jie; Li, Tingyu

doi:10.1080/1028415x.2017.1423268

Cited by 58 publications

(38 citation statements)

References 42 publications

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“…The results showed that in children with AD, serum VD levels were negatively correlated with the severity of the disease ( r = –0.3880, p = 0.0004), consistent with the results of previous studies [19, 22, 23] (Fig. 2a).…”

Section: Resultssupporting

confidence: 82%

“…Oh et al [20] reported that the incidence of AD was negatively correlated with the intake of antioxidant nutrients (including retinol and β-carotene), and Mihály et al [21] found decreased retinoid concentration and retinoid signalling pathways in human AD patients. Our previous studies demonstrated that VA and VD co-deficiency may exacerbate the symptoms of children with autism spectrum disorders [22]. No studies have reported the serum levels of VA in children with AD or explored whether there is a synergistic effect between VD and VA in AD patients.…”

Section: Introductionmentioning

confidence: 99%

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Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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Background: Several studies have suggested that vitamin D (VD) deficiency (VDD) is associated with atopic dermatitis (AD). However, little is known about the relationship between AD and vitamin A (VA). The interaction between VA and VD on AD requires further study. Objective: We detected serum levels of VA and VD in children with AD to explore how VA deficiency (VAD) and VDD affect AD severity. Methods: We assessed the SCORing Atopic Dermatitis (SCORAD) index, total immunoglobin E levels and peripheral blood eosinophil counts. VA and VD levels were determined with high-performance liquid chromatography. Correlations among variables were investigated with Pearson’s correlation analysis. Results: The VD and VA levels were significantly lower in children with AD than in normal children (p < 0.001, p = 0.0423). Both VD and VA levels were negatively correlated with SCORAD scores. The SCORAD scores were significantly higher in AD patients with both VDD and VAD (co-deficiency) than in other AD patients. Significant inverse correlations were observed between peripheral blood eosinophil counts and serum VA and VD levels. Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.

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Section: Resultssupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Xiang

Wang

2019

Dermatology

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“…Vitamin A de ciency (VAD) is still a public health issue in many developing countries. Studies showed ASD children are more vulnerable to VAD than neurotypical children [19] [20]. In our study, an increased level of 4'-apo-beta-carotenal, b,e-carotene-3,3'-diol and decreased retinol may indicate that ASD children had decreased capacity of absorption and bioconversion of plant-origin precursors of vitamin A. Vitamin A has three active forms, retinal, retinol and retinoic acid (RA) in humans [21].…”

Section: Discussionmentioning

confidence: 56%

Alterations in Gut Vitamins and Amino Acids Metabolism are Associated with Symptoms and Neurodevelopment of Children with Autism Spectrum Disorders

Zhu

Hua

Yang

et al. 2020

Preprint

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Background Accumulated evidence have supported metabolic disturbance may be associated with the pathogenesis of autism spectrum disorders (ASD). Despite abnormalities of some shared metabolic pathways, specific differential compounds are inconsistent in studies, which made a challenge to elucidate the role of metabolism in the mechanism of ASD. Besides, few researches have assessed the correlation between gut metabolites with symptoms of ASD. Objectives The present study aimed to evaluate the gut metabolomic profiles of children with ASD and to analyze potential interaction between gut metabolites with symptoms and neurodevelopment of ASD children. Methods In this cross-sectional case-control study, 120 aged 2–6 years ASD children and 60 sex and age matched typically developing (TD) children were included. Autistic symptoms were assessed with the Autism Behavior Checklist (ABC), Childhood Autism Rating Scale (CARS), and the Social Responsiveness Scale (SRS). Neurodevelopment was assessed with the Gesell Developmental Scale (GDS). Fecal samples were analyzed by untargeted liquid chromatography-mass spectrometry (LC-MS) methods, then systematic bioinformatic analyses were performed to characterize the gut metabolomic profiles of ASD and TD children. The correlations between metabolites and clinical assessment scores were assessed using Spearman correlation. Results ASD children exhibit gut metabolism perturbation compared with TD children. A total of 96 differential metabolites between the ASD and TD groups were identified, with 35 increased and 61 decreased in ASD group. The metabolic disturbance of ASD involved in multiple vitamins and amino acids metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine and methionine metabolism, and vitamin digestion and absorption. The imbalanced gut metabolites are significantly correlated to symptoms and neurodevelopment of ASD children. Limitations This cross-sectional study revealed a correlation, but do not allow to prove causation of symptoms and gut metabolites outcome. The disease specificity of the metabolomic disturbance need to be evaluated in future studies.Conclusions ASD children have altered gut metabolite profiles compared with TD children, which mainly involved in multiple vitamins and amino acids metabolism pathways. Notably, vitamins metabolism abnormalities may play roles in the disturbance of amino acids metabolism. Imbalanced gut metabolites are related to symptoms and neurodevelopment of ASD children. Our findings provided an improved understanding of perturbations of metabolome networks in ASD.

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“…Otizm hastalarında Guo ve ark. 27 A vitamin düzeyinin, Bakkaloğlu ve ark. 28 A, C ve E vitamin düzeylerinin, Al-Gadani ve ark.…”

Section: Gereç Ve Yöntemunclassified

Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Çocuk ve Ergenlerde Serum Anti-oksidan Vitamin Düzeyleri

Kul¹,

Kara²,

Önol³

et al. 2019

tjcamh

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Objectives: The etiological causes of attention deficit and hyperactivity disorder (ADHD) are not fully understood yet. Recent studies have reported that the anti-oxidant activity is reduced and the oxidative stress is increased in ADHD. The aim of this study is to compare serum antioxidant vitamin levels, which are important components of anti-oxidant defense system, between the children and adolescents with ADHD and healthy controls. Materials and Methods: Serum levels of vitamin A, C and E were compared between 39 children and adolescents diagnosed with ADHD and 25 healthy controls with similar age and gender by using clinical evaluation and rating scales. Results: There were no significant differences in serum vitamin A,C and E levels between ADHD and control groups. Conclusion: This study concludes no significant effect of serum A, C and E vitamin levels on ADHD. There is still need for future studies on larger samples.

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Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders

Abstract: We found that children with autism have more VA and VD deficiencies than control children, and VA and VD co-deficiency may exacerbate the symptoms of children with ASD.

Cited by 58 publications

References 42 publications

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children

Alterations in Gut Vitamins and Amino Acids Metabolism are Associated with Symptoms and Neurodevelopment of Children with Autism Spectrum Disorders

Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Çocuk ve Ergenlerde Serum Anti-oksidan Vitamin Düzeyleri

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