Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Schwartz, Stephen G.; Wang, Xue; Chavis, Pamela S.; Kuriyan, Ajay E.; Abariga, Samuel A

doi:10.1002/14651858.cd008428.pub3

Cited by 22 publications

(18 citation statements)

References 38 publications

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“…RP is a rare genetic disorder with a prevalence of approximately 1:4000, which is caused by the degeneration of photoreceptors in retina [ 67 , 68 ]. Degeneration starts from rods on the periphery, but at the latter stage, cones in the macula and fovea are also affected.…”

Section: Role Of Ret In Various Disease Statesmentioning

confidence: 99%

“…The condition is incurable. Some reports suggest protective effects of vitamin A and fish oils in RP patients, but the recent Cochrane systematic review concludes that the benefits of these treatments are uncertain [ 68 ]. The genetics of RP is diverse and complex; mutations in more than 40 genes were found to be associated with the disease [ 70 ].…”

Section: Role Of Ret In Various Disease Statesmentioning

confidence: 99%

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RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer

Mahato

Sidorova

2020

IJMS

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Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal circumstances interacts with ligand at the cell surface and mediates various essential roles in a variety of cellular processes such as proliferation, differentiation, survival, migration, and metabolism. RET plays a pivotal role in the development of both peripheral and central nervous systems. RET is expressed from early stages of embryogenesis and remains expressed throughout all life stages. Mutations either activating or inhibiting RET result in several aggressive diseases, namely cancer and Hirschsprung disease. However, the physiological ligand-dependent activation of RET receptor is important for the survival and maintenance of several neuronal populations, appetite, and weight gain control, thus providing an opportunity for the development of disease-modifying therapeutics against neurodegeneration and obesity. In this review, we describe the structure of RET, its signaling, and its role in both normal conditions as well as in several disorders. We highlight the differences in the signaling and outcomes of constitutive and ligand-induced RET activation. Finally, we review the data on recently developed small molecular weight RET agonists and their potential for the treatment of various diseases.

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Section: Role Of Ret In Various Disease Statesmentioning

confidence: 99%

Section: Role Of Ret In Various Disease Statesmentioning

confidence: 99%

RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer

Mahato

Sidorova

2020

IJMS

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“…However, visual acuity mainly re ects the retinal function around the fovea and tends to be insensitive to the disease severity. 35 In contrast, we recently showed that the structural damage in RP, such as fundus auto uorescence, was more accurately measured by VF sensitivity 34,35 using the HFA 10 − 2 test. 36 The current results will be useful when assessing the effects of any candidate treatment on the progression of VF with the HFA 10 − 2 test.…”

Section: Discussionmentioning

confidence: 95%

“…In a recent meta-analysis, the effectiveness of vitamin A was uncertain because the treatment outcomes varied widely across studies. [27][28][29][30][31][32][33][34] One reason for the contradicting results was the different visual function assessments across the studies. 34 Even visual acuity was often used for the assessment of visual function.…”

Section: Discussionmentioning

confidence: 99%

The Association Between the Number of Visual Fields and the Accuracy of Future Prediction in Eyes With Retinitis Pigmentosa

Asaoka

Oishi

Fujino

et al. 2021

Preprint

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The purpose of the study was to evaluate the minimum number of visual fields (VFs) required to precisely predict future VFs in eyes with retinitis pigmentosa (RP). A series of 12 VFs (Humphrey Field Analyzer 10-2 test, (8.9 years in average) were analyzed from 102 eyes of 52 RP patients. The absolute error to predict the 12th VF using the prior 11 VFs was calculated in a pointwise manner, using the linear regression, and the 95% confidence interval (CI) range was determined. Then, using 3 to 10 initial VFs, next VFs (4th to 11th VFs, respectively) were also predicted. The minimum number of VFs required for the mean absolute prediction error to reach the 95% CI was identified. Similar analyses were iterated for the second and third next VF predictions. Similar analyses were conducted using mean deviation (MD). In the pointwise analysis, the minimum number of VFs required to reach the 95% CI for the 12th VF was 5 (first and second next VF predictions) and 6 (third next VF prediction). For the MD analysis, 3 (first and second next VF predictions) and 4 (third next VF prediction) VFs were required to reach 95% CI for the 12th VF.

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“…However a recent meta-analysis suggested that treatment outcomes varied widely across studies 24 – 31 . A reason for contradicting results would be the different VF assessments across the studies 31 . The current results would be relevant when assessing the effect of such possible treatment using point-wise VF progression with HFA 10-2 test.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a visual field cluster in retinitis pigmentosa

Fujishiro

Oishi

Asaoka

et al. 2021

Sci Rep

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The aim was to establish and evaluate a new clustering method for visual field (VF) test points to predict future VF in retinitis pigmentosa. A Humphrey Field Analyzer 10-2 test was clustered using total deviation values from 858 VFs. We stratified 68 test points into 24 sectors. Then, mean absolute error (MAE) of the sector-wise regression with them (S1) was evaluated using 196 eyes with 10 VF sequences and compared to pointwise linear regression (PLR), mean sensitivity of total area (MS) and also another sector-wise regression basing on VF mapping for glaucoma (29 sectors; S2). MAE with S1 were smaller than with PLR when between the first-third and first-seventh VFs were used. MAE with the method were significantly smaller than those of S2 when between the first-sixth and first-ninth VFs were used. The MAE of MS was smaller than those with S1 only when first to 3rd and first to 4th VFs were used; however, the prediction accuracy became far larger than any other methods when larger number of VFs were used. More accurate prediction was achieved using this new sector-wise regression than with PLR. In addition, the obtained cluster was more useful than that for glaucoma to predict progression.

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Vitamin A and fish oils for preventing the progression of retinitis pigmentosa

Cited by 22 publications

References 38 publications

RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer

RET Receptor Tyrosine Kinase: Role in Neurodegeneration, Obesity, and Cancer

The Association Between the Number of Visual Fields and the Accuracy of Future Prediction in Eyes With Retinitis Pigmentosa

Development and validation of a visual field cluster in retinitis pigmentosa

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