Vitamin a and Carcinogenesis

Sure, Barnett; Buchanan, K. S.; Thatcher, Harvey S.

doi:10.1158/ajc.1936.84

Cited by 7 publications

(1 citation statement)

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“…Using various amounts of vitamin A, making proper control for vitamin A-deficient diet, and transplantation of tumour in mice, he found that normal cell growth is not differently influenced by the amount of vitamin A, and that tumour development is inhibited by feeding with vitamin A. 73,74 Clinical reports in 1937 and 1938 established that many cases of human gastric cancer were due to vitamin A deficiency. [75][76][77] The complete review of Fibiger's works was published by Clemmesen in 1978.…”

Section: Refutationmentioning

confidence: 99%

The making of oncology: The tales of false carcinogenic worms

Lalchhandama¹

2017

Sci Vis

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Cancer is a disease of antiquity. The Ancient Greeks were familiar with onkos (from which we have the term oncology)—tumour of all sorts. Hippocrates coined karkinos and karkinoma, our source of the words cancer and carcinoma. Of a plethora of carcinogens, parasitic worms (helminths) constitute a considerable health concern. Three trematodes, Clonorchis sinensis, Opisthorchis viverrini, and Schistosoma haematobium are now officially classified carcinogens. But the discovery of helminths as cancer-causing agents took wrong turns and marks an inglorious chapter in the history of science. The carcinogenicity of worms, vindicating Rudolf Virchow’s reiztheorie (irritation theory) of cancer origin, was glorified in the scientific forefront by Johannes Fibiger in the 1910s. Discovery of a new nematode, which he proudly named Spiroptera carcinoma, and his subsequent demonstration that the parasite could induce stomach cancer in rats, earned Fibiger a retrospective Nobel Prize in Physiology or Medicine in 1926, and a lasting fame. But not in an appealing way. His achievement did not withstand the test of time. S. carcinoma was annulled as an invalid taxon in zoology—supplanted by Gongylonema neoplasticum—and eventually was branded as a non-carcinogenic agent.

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Section: Refutationmentioning

confidence: 99%

The making of oncology: The tales of false carcinogenic worms

Lalchhandama¹

2017

Sci Vis

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Diseases of Metabolism and Nutrition

Wilder¹

1939

Arch Intern Med (Chic)

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On the epidemiology of nasopharyngeal carcinoma

Clifford

1970

Intl Journal of Cancer

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The incidence of nasopharyngeal carcinoma is high in Chinese in South East China and in those living in a traditional Chinese manner in the countries of South East Asia. The related Mongoloid peoples of Japan and Korea have a low incidence, as do the Caucasians of Europe, America and India. In Chinese born abroad and living in a “Western”‐type environment in Australia, Hawaii and California the incidence falls significantly. This suggests that the high incidence in the Chinese relates to a genetically determined racial or “line” predisposition combined with environmental factors or to environmental factors alone. In Kenya, ethnic origin does not relate to incidence which depends on environmental factors only. The possible significance of genetic factors cannot be assessed until adequate information on the genetic profiles of racial groups with high and low incidences is available. Different environmental factors may be of importance. Biologic agents such as fungi or viruses may be of importance in some areas, in others a physical or chemical agent may be of significance, or the cancer may arise following exposure to a combination of factors. In some areas inhalation of polynuclear hydrocarbons may be of importance, in others the ingestion of nitrosamine‐like compounds, and these external agents may only be effective if combined with a viral infection, possibly the Epstein‐Barr virus or with a particular nutritional or hormonal status. The local tissue sensitivity is the factor which determines the response to any particular external agent. Examination of the external environment is, perhaps, of less importance than that of the milieu intérieur, as it is now recognized that the stability of the respiratory epithelium is affected by hormonal and nutritional factors. Universally the incidence in men is higher than in women, and this may relate to their different internal environments.

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Vitamin a and Carcinogenesis

Cited by 7 publications

References 0 publications

The making of oncology: The tales of false carcinogenic worms

The making of oncology: The tales of false carcinogenic worms

Diseases of Metabolism and Nutrition

On the epidemiology of nasopharyngeal carcinoma

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