“…There is variation in the vital sign abnormalities used to activate RRS and the vital sign abnormalities most commonly associated with RRS afferent limb failure. For example, blood pressure derangements, tachycardia, tachypnoea, altered conscious state and hyperthermia have been associated with higher likelihood of RRS activation (Considine, Hutchinson, et al., 2023; Davies et al., 2014; Flabouris et al., 2015) and bradycardia, decreased conscious state and hypothermia are significantly less likely to result in RRS activation (Considine, Hutchinson, et al., 2023; Flabouris et al., 2015). The reason why some vital signs are more or less likely to result in RRS activations is unclear.…”