Vital exhaustion in relation to lifestyle and lipid profile in healthy women

Koertge, Jenny; Ahnve, Staffan; Schenck‐Gustafsson, Karin; Orth‐Gomér, Kristina; Wamala, Sarah

doi:10.1207/s15327558ijbm1001_04

Cited by 28 publications

(17 citation statements)

References 31 publications

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“…Vital exhaustion is associated with a number of metabolic, hemodynamic, and immune responses that are known to be important for the development and progression of cardiovascular disease. Included among them are: abnormal lipid metabolism (4), decreased fibrinolysis and increased coagulation (5, 6), diurnal variations in fibrinolysis and coagulation (7), and low heart rate variability (8). Vital exhaustion is also associated with increased immune-mediated inflammation, which is a key factor in atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Vital Exhaustion as a Risk Factor for Adverse Cardiac Events (from the Atherosclerosis Risk In Communities [ARIC] Study)

Williams

Mosley

Kop

et al. 2010

The American Journal of Cardiology

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Vital exhaustion, defined as excessive fatigue, feelings of demoralization, and increased irritability, has been identified as a risk factor for incident and recurrent cardiac events, but there are no prospective studies of this association in United States samples. We examined the predictive value of vital exhaustion for incident myocardial infarction or fatal coronary heart disease (CHD) among middle-aged men and women in four US communities. Participants were 12,895 black or white men and women enrolled in the Atherosclerosis Risk In Communities (ARIC) Study cohort and followed for the occurrence of cardiac morbidity and mortality from 1990 through 2002 (maximum follow-up = 13.0 years). Vital exhaustion was assessed using the 21-item Maastricht Questionnaire, and partitioned into approximate quartiles for statistical analyses. High vital exhaustion (the fourth quartile) predicted adverse cardiac events in age-, gender-, and race-center-adjusted analyses (1.69 [95% C.I: 1.40 to 2.05]) and in analyses further adjusted for educational level, body mass index, plasma low density lipoprotein-and high density lipoprotein-cholesterol, systolic and diastolic blood pressure levels, diabetes mellitus, cigarette smoking status, and pack-years of cigarette smoking (1.46 [95% C.I: 1.20 to 1.79]). The risk for adverse cardiac events increased monotonically from the first through the fourth quartile of vital exhaustion. The probabilities of adverse cardiac events over time were significantly higher in people with high vital exhaustion compared to those with low exhaustion (p = 0.002). In conclusion, vital exhaustion predicts the long-term risk for adverse cardiac events in men and women, independent of the established biomedical risk factors.

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Section: Discussionmentioning

confidence: 99%

Vital Exhaustion as a Risk Factor for Adverse Cardiac Events (from the Atherosclerosis Risk In Communities [ARIC] Study)

Williams

Mosley

Kop

et al. 2010

The American Journal of Cardiology

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“…On the other hand, some studies have described psychological factors in triggering of various diseases such as coronary heart disease, 14 fatigue and excessive work as important in the regulation of biological parameters, such as lipid profiles, 15 and psychological events as modulators of immune response. 16 Other studies have evoked stress and fatigue as worsening factors for headaches and chronic CNS diseases, respectively.…”

Section: Discussionmentioning

confidence: 99%

Diseases of the nervous system: patients' aetiological beliefs

Croquelois

Assal²,

Annoni³

et al. 2005

Journal of Neurology, Neurosurgery & Psychiatry

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“…In a study of healthy employees (Shirom, Westman, Shamai, & Carel, 1997), burnout in men was found to be predictive of cholesterol changes, evidenced two to three years later. A measure of burnout called vital exhaustion (VE) was found to be positively associated with atherogenic lipid profile in one study (Koertge, Ahnve, Schenck‐Gustafsson, Orth‐Gomer, & Wamala, 2003). As is evident from qualitative (Pressman & Cohen, 2005) and quantitative (Chida & Steptoe, 2008) reviews of positive affect and physical health, most past studies on these associations have used global measures of positive affects such as the Positive and Negative Affect Schedule (Watson, Clark, & Tellegen, 1988).…”

Section: Introductionmentioning

confidence: 99%

Burnout and Vigor as Predictors of the Incidence of Hyperlipidemia among Healthy Employees

Shirom

Toker

Melamed

et al. 2012

Applied Psych Health & Well

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We examined the effects of burnout and vigor on the incidence of hyperlipidemia. Based on the bivariate theoretical approach to negative and positive affects and on past studies on the prediction of blood lipids by burnout and vigor, we expected increases from Time 1 (T1) to Time 2 (T2) in burnout levels to be associated with an increase in the risk for hyperlipidemia and T1-T2 increases in vigor levels to be associated with a decrease in the risk of hyperlipidemia. Our sample consisted of 3,337 healthy employees (2,214 men and 1,123 women) who were followed up for about 27 months on average. Burnout and vigor were assessed by well-validated multiple-item instruments. We used logistic regressions and controlled for variables associated with blood lipids as well as with vigor and burnout. We cross-validated all self-reported hyperlipidemia by their T2 lipids levels. As expected, we found that T1-T2 increases in vigor levels were associated with a decreased risk of hyperlipidemia. However, the T1-T2 change in burnout levels was marginally significant (p = .06) in predicting hyperlipidemia. We consider our finding that vigor and burnout are independently associated with the risk of hyperlipidemia as providing support for the bivariate approach to affective states. In addition, our major finding suggests a possible mechanism via which vigor influences physical health outcomes.

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Vital exhaustion in relation to lifestyle and lipid profile in healthy women

Cited by 28 publications

References 31 publications

Vital Exhaustion as a Risk Factor for Adverse Cardiac Events (from the Atherosclerosis Risk In Communities [ARIC] Study)

Vital Exhaustion as a Risk Factor for Adverse Cardiac Events (from the Atherosclerosis Risk In Communities [ARIC] Study)

Diseases of the nervous system: patients' aetiological beliefs

Burnout and Vigor as Predictors of the Incidence of Hyperlipidemia among Healthy Employees

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