If the United States had undertaken road building or space exploration in the same way it is chasing health system reform, there would be neither an interstate highway system nor footprints on the moon. The successes depended on clear, bold, shared aims; strong investments in technical mastery; continuity of purpose over time; and continual learning at a large scale-not to mention considerable celebration. Health care reform has had none of these. The reasons for the difference are many. The National Aeronautics and Space Administration (NASA) undoubtedly faced political headwinds, but they were not gale force, because NASA was not dealing with $3 trillion of the US economy, a panoply of stakeholders with financial interests in the status quo of health care, professional fragmentation, or a viciously complicated legacy payment system designed by no one at all. In addition, NASA's tools-such as rockets and orbital mathematics-were fit for purpose, or could be made so. There was no prior moon shot to be displaced. Also, NASA did not have to traverse a political landscape like that of health care reform, full of foxholes and trenches, with unprecedented factionalism overwhelming civil discourse and evidence-based inquiry. Into this landscape, the report in this issue of JAMA titled "Vital Directions for Health and Health Care: Priorities From a National Academy of Medicine Initiative" 1 brings some welcome sense making. A stellar, bipartisan steering committee, drawing on advice from more than 150 of "the nation's leading health and policy experts," 1 commissioned 19 discussion papers and offers a summary of 8 crosscutting policy priorities that those papers invoke. Their summary clearly reviews the magnitude of the problems in the current system, such as unreasonably high costs (now at $3.2 trillion per year), waste levels of 30% or more, persistent and unconscionable health disparities, vast failure to address social and behavioral causes of illness, and consequent, erosive burdens on the fiscal well-being of governments, the private sector, and working families. But it also notes with optimism "compelling opportunities and novel tools" 1 for solving those problems, solutions that can thrive if conditions are set properly. The authors denote 4 of their policy priorities as action priorities. These include (1) continuing and accelerating a shift of payment from volume to outcomes and value, especially to support stronger integration of health and social services; (2) empowering people with better health literacy, telehealth, data access, and attention to the health-related goals of individuals; (3) activating communities to strengthen public health and social care supports, especially for people