Vit. D Binding Protein As A Diagnostic Marker For Isocyanate-induced Occupational Asthma

Choi, Gil-Soon; Hur, Gyu-Young; Kim, J.; Sung, Jun-Mo; Palikhe, Nami Shrestha; Jeon, In Soo; Ye, Y.; Park, H.

doi:10.1016/j.jaci.2008.12.1034

Cited by 1 publication

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“… 30 Another candidate protein as a serologic marker for detecting isocyanate-OA among isocyanate-exposed workers was the serum vitamin D binding protein (VDBP) level. 31 To confirm this, additional functional studies are ongoing.…”

Section: Protein Markersmentioning

confidence: 95%

“…However, a recent study performed in Spain showed that the serum ferritin and transferrin levels did not differ among TDI-OA, TDI-exposed workers without OA, or healthy controls; therefore, these potential markers need to be studied further before they can be used 30. Another candidate protein as a serologic marker for detecting isocyanate-OA among isocyanate-exposed workers was the serum vitamin D binding protein (VDBP) level 31. To confirm this, additional functional studies are ongoing.…”

Section: Protein Markersmentioning

confidence: 99%

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Biomarkers Predicting Isocyanate-Induced Asthma

Palikhe

Kim

Park

2011

Allergy Asthma Immunol Res

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Three diisocyanates can cause occupational asthma (OA): toluene diisocyanate (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate (HDI). We analyzed potential biomarkers of isocyanate-induced OA, based on investigated immunologic, genetic, neurogenic, and protein markers, because there is no serological testing method. The prevalence of serum IgG to cytokeratin (CK)18 and CK19 in TDI-OA was significantly higher than in controls, although the prevalence of these antibodies was too low for them to be used as biomarkers. Another candidate biomarker was serum IgG to tissue transglutaminase (tTG), because the prevalence of serum specific IgG to tTG was significantly higher in patients with TDI-OA than in controls. The human leukocyte antigen (HLA) DRB1*1501-DQB1*0602-DPB1*0501 haplotype may be used as a genetic marker for TDI-OA in Koreans via enhanced specific IgE sensitization in exposed subjects. The genetic polymorphisms of catenin alpha 3, alpha-T catenin (CTNNA3) were significantly associated with TDI-OA. Additionally, examining the neurokinin 2 receptor (NK2R) 7853G>A and 11424 G>A polymorphisms, the NK2R 7853GG genotype had higher serum vascular endothelial growth factor (VEGF) levels than the GA or AA genotypes among Korean workers exposed to TDI. To identify new serologic markers using a proteomic approach, differentially expressed proteins between subjects with MDI-OA and asymptomatic exposed controls in a Korean population showed that the optimal serum cutoff levels were 69.8 ng/mL for ferritin and 2.5 µg/mL for transferrin. When these two parameters were combined, the sensitivity was 71.4% and the specificity was 85.7%. The serum cytokine matrix metalloproteinase-9 (MMP-9) level is a useful biomarker for identifying cases of TDI-OA among exposed workers. Despite these possible biomarkers, more effort should be focused on developing early diagnostic biomarkers using a comprehensive approach based on the pathogenic mechanisms of isocyanate-induced OA.

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Section: Protein Markersmentioning

confidence: 95%

Section: Protein Markersmentioning

confidence: 99%