Visuospatial dysfunction and problem solving in Parkinson's disease.

Cronin‐Golomb, Alice; Braun, Ann E.

doi:10.1037//0894-4105.11.1.44

Cited by 26 publications

(1 citation statement)

References 3 publications

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“…Initial cognitive impairments in PD can occur in a range of cognitive domains. 9,12,13 Predictors of cognitive impairment include older age and age at disease onset, greater disease severity, postural instability-gait disorder subtype, REM sleep behavior disorder, and psychiatric symptoms (e.g., psychosis and depression). 14 Unfortunately, treatment of PD cognitive impairment lags treatment of motor symptoms.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Dementia Risk in Parkinson Disease

Gallagher,

Gochanour,

Caspell-Garcia

et al. 2024

Neurology

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Background and ObjectivesIt is widely cited that dementia occurs in up to 80% of patients with Parkinson disease (PD), but studies reporting such high rates were published over two decades ago, had relatively small samples, and had other limitations. We aimed to determine long-term dementia risk in PD using data from two large, ongoing, prospective, observational studies. MethodsParticipants from the Parkinson's Progression Markers Initiative (PPMI), a multisite international study, and a long-standing PD research cohort at the University of Pennsylvania (Penn), a single site study at a tertiary movement disorders center, were recruited. PPMI enrolled de novo, untreated PD participants and Penn a convenience cohort from a large clinical center. For PPMI, a cognitive battery is administered annually, and a site investigator makes a cognitive diagnosis. At Penn, a comprehensive cognitive battery is administered either annually or biennially, and a cognitive diagnosis is made by expert consensus. Interval-censored survival curves were fit for time from PD diagnosis to stable dementia diagnosis for each cohort, using cognitive diagnosis of dementia as the primary end point and Montreal Cognitive Assessment (MoCA) score <21 and Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I cognition score ≥3 as secondary end points for PPMI. In addition, estimated dementia probability by PD disease duration was tabulated for each study and end point. ResultsFor the PPMI cohort, 417 participants with PD (mean age 61.6 years, 65% male) were followed, with an estimated probability of dementia at year 10 disease duration of 9% (site investigator diagnosis), 15% (MoCA), or 12% (MDS-UPDRS Part I cognition). For the Penn cohort, 389 participants with PD (mean age 69.3 years, 67% male) were followed, with 184 participants (47% of cohort) eventually diagnosed with dementia. The interval-censored curve for the Penn cohort had a median time to dementia of 15 years (95% CI 13-15); the estimated probability of dementia was 27% at 10 years of disease duration, 50% at 15 years, and 74% at 20 years.

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Section: Introductionmentioning

confidence: 99%

Long-Term Dementia Risk in Parkinson Disease

Gallagher,

Gochanour,

Caspell-Garcia

et al. 2024

Neurology

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Characterization of Motor and Non-Motor Behavioral Alterations in the Dj-1 (PARK7) Knockout Rat

et al. 2019

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Episodic recognition memory and the hippocampus in Parkinson's disease: A review

Das

Hwang

Poston

2019

Cortex

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Parkinson's disease is a progressive neurodegenerative disorder of aging. The hallmark pathophysiology includes the development of neuronal Lewy bodies in the substantia nigra of the midbrain with subsequent loss of dopaminergic neurons. These neuronal losses lead to the characteristic motor symptoms of bradykinesia, rigidity, and rest tremor. In addition to these cardinal motor symptoms patients with PD experience a wide range of non-motor symptoms, the most important being cognitive impairments that in many circumstances lead to dementia. People with PD experience a wide range of cognitive impairments; in this review we will focus on memory impairment in PD and specifically episodic memory, which are memories of day-today events of life. Importantly, these memory impairments severely impact the lives of patients and caregivers alike. Traditionally episodic memory is considered to be markedly dependent on the hippocampus; therefore, it is important to understand the exact nature of PD episodic memory deficits in relation to hippocampal function and dysfunction. In this review, we discuss an aspect of episodic memory called recognition memory and its subcomponents called recollection and familiarity. Recognition memory is believed to be impaired in PD; thus, we discuss what aspects of the hippocampus are expected to be deficient in function as they relate to these recognition memory impairments. In addition to the hippocampus as a whole, we will discuss the role of hippocampal subfields in recognition memory impairments.

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Visuospatial dysfunction and problem solving in Parkinson's disease.

Cited by 26 publications

References 3 publications

Long-Term Dementia Risk in Parkinson Disease

Long-Term Dementia Risk in Parkinson Disease

Characterization of Motor and Non-Motor Behavioral Alterations in the Dj-1 (PARK7) Knockout Rat

Episodic recognition memory and the hippocampus in Parkinson's disease: A review

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