Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies.

Hamilton, Joanne M.; Salmon, David P.; Galasko, Douglas; Raman, Rema; Emond, Jenn; Hansen, Lawrence A.; Masliah, Eliezer; Thal, Leon J.

doi:10.1037/a0012949

Cited by 73 publications

(72 citation statements)

References 55 publications

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“…Since the cognitive scores might inform the clinical diagnosis, there is a potential circularity in such findings, and thus the current results provide additional support for the hypothesis that mild DLB is associated with a characteristic cognitive profile. Similar findings have also been reported in neuropathologically confirmed cases of endstage DLB [27] .…”

Section: Discussionsupporting

confidence: 77%

Core and Suggestive Symptoms of Dementia with Lewy Bodies Cluster in Persons with Mild Dementia

Rongve

Brønnick

Ballard

et al. 2010

Dement Geriatr Cogn Disord

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Objectives: To explore how the core and suggestive symptoms of dementia with Lewy bodies (DLB) cluster in persons with newly diagnosed mild dementia, and whether they are associated with a particular pattern of cognitive impairment. Method: Persons with mild dementia (n = 139) were recruited from dementia clinics in western Norway. Symptoms were rated using standardized instruments. A 2-step cluster analysis was applied to classify persons into groups according to scores on scales for hallucinations, parkinsonism, fluctuations and REM sleep behaviour disorder (RBD). Result: Four distinct clusters were revealed: a ‘Lewy body dementia’ (LBD) cluster with high scores for hallucinations, parkinsonism and fluctuation, and a ‘non-LBD’ cluster with low scores on all DLB symptom scales. In addition, 2 clusters with high scores on either RBD or cognitive fluctuation scales emerged. Persons in the LBD cluster had lower scores for visuospatial cognitive abilities as compared to the non-LBD group (p = 0.002). Conclusion: Applying cluster analysis, we identified distinct subgroups in mild dementia based on symptoms such as hallucinations, parkinsonism and cognitive fluctuations. Our findings provide empirical support for diagnosing DLB. Visual hallucinations and motor parkinsonism might be the most distinguishing symptoms for DLB in mild dementia.

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Section: Discussionsupporting

confidence: 77%

Core and Suggestive Symptoms of Dementia with Lewy Bodies Cluster in Persons with Mild Dementia

Rongve

Brønnick

Ballard

et al. 2010

Dement Geriatr Cogn Disord

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“…However, several studies employing CDT did not report significant differences in overall total score in LBD and AD patients [156,157], likely because of the complexity of the task (see Fig. 1), although at least two studies reported significantly lower overall scores in LBD versus AD patients [158,159].…”

Section: Drawing Disorders In Lewy Body Dementiamentioning

confidence: 98%

“…No 2-year decline in FTD Comparison AD-LBD Nervi [152] Figure copying LBD worse than AD Crowell [153] Figure copying LBD worse than AD Tiraboschi [154] Figure copying LBD worse than AD; no differences in pentagon copying Cahn-Wiener [156] CDT No differences in overall score, but more conceptual and planning errors in LBD Hamilton [157] Clock copying No differences, but lower scores predicted steeper decline in LBD Cagnin [158] CDT LBD worse than AD Palmqvist [159] CDT, cube copying LBD worse than AD Gnanalingham [162] CDT, clock copying No difference in CDT; LBD worse than AD in clock copying Ala [164] Pentagon copying LBD worse than AD Cormack [165] Pentagon copying LBD worse than AD Connor [166] Pentagon copying No difference Caffarra [167] Figure copying, No difference in figure copying, pentagon copying worse scores in LBD on an analytic scoring system for pentagon copying AD, Alzheimer's disease; VaD, vascular dementia; sVaD, subcortical VaD; FTD, frontotemporal dementia; bvFTD, behavioral variant of FTD; PA, progressive aphasia; LBD, Lewy body dementia; CDT, Clock drawing test; ROCF, copy of Rey's complex figure. Reference numbering follows the text.…”

Section: Drawing Disorders In Vascular Dementiamentioning

confidence: 99%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

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Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

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“…Similar studies have been performed concerning the association between the PCT or the CDT and cognitive function in patients with DLB and Parkinson's disease [25,26]. One study showed that DLB patients with low scores on the CDT had faster cognitive decline than DLB patients with high scores on the CDT [25].…”

Section: Discussionmentioning

confidence: 73%

“…One study showed that DLB patients with low scores on the CDT had faster cognitive decline than DLB patients with high scores on the CDT [25]. Another study showed that low scores on the PCT were associated with cognitive decline in Parkinson's disease [26].…”

Section: Discussionmentioning

confidence: 99%

The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies

Vergouw

Salomé

Kerklaan

et al. 2018

Dement Geriatr Cogn Disord

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Aims: To determine whether the pentagon copying test (PCT) and the clock drawing test (CDT) are associated with nursing home admission or survival in dementia with Lewy bodies (DLB). Methods: The PCT and/or the CDT were retrospectively collected from 103 clinically diagnosed probable DLB patients at a university medical center and general hospital. Patients with high versus low scores on these tests were compared. Results: Kaplan-Meier analysis showed that patients with a low score on the PCT had a shorter time to nursing home admission than patients with a high score (log-rank χ² = 6.1, p = 0.01). Patients with a low score on the PCT or the CDT had a shorter survival than patients with a high score (log-rank χ² = 5.4, p = 0.02, and log-rank χ² = 11.2, p < 0.001, respectively). Cox regression analyses showed the same associations with an HR of 2.2 (95% CI 1.2–4.1) for the PCT and an HR of 2.9 (95% CI 1.6–5.4) for the CDT. Conclusion: The PCT and the CDT may function as prognostic markers in DLB. This finding is clinically relevant as these tests can be applied easily in the clinical setting and can provide valuable prognostic information. Furthermore, it may improve disease management and patient selection for research purposes.

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Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies.

Cited by 73 publications

References 55 publications

Core and Suggestive Symptoms of Dementia with Lewy Bodies Cluster in Persons with Mild Dementia

Core and Suggestive Symptoms of Dementia with Lewy Bodies Cluster in Persons with Mild Dementia

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies

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