Visuo-attentional correlates of Autism Spectrum Disorder (ASD) in children with Down syndrome: A comparative study with children with idiopathic ASD

Glennon, Jennifer M.; D’Souza, Hana; Mason, Luke; Karmiloff‐Smith, Annette; Thomas, Michael S. C.

doi:10.1016/j.ridd.2020.103678

Cited by 7 publications

(5 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although search slope (an indicator of search efficiency reflective of attentional shifting between array items and the ability to filter irrelevant items) was not associated with social functioning (ADOS Social domain), the intercept (reaction time if the visual search component was removed from the task) in the static/target present condition was negatively associated with the ADOS Social domain score. Participants in Glennon et al (2020) were required to identify a red apple embedded within an array of blue apple and red rectangle distractor targets. Although faster target detection was identified in children (both ASD and Down syndrome) with higher scores on the SRS‐2, search latency did not predict SRS‐2 scores in children with ASD.…”

Section: Resultsmentioning

confidence: 99%

“…Results were mixed. Glennon et al (2020) found that reduced facilitation (the difference in saccadic reaction time between gap and baseline trials) was associated with higher scores on the SRS‐2 in ASD. However, using auditory (rather than visual) central and peripheral stimuli, Keehn et al (2019) found that disengagement efficiency (saccadic reaction time divided by the number of trials in which a gaze shift occurred) across gap/overlap/baseline conditions was not associated with scores on the ADOS‐2 (calibrated severity score) or SRS‐2 (Total score).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta‐analysis

et al. 2022

View full text Add to dashboard Cite

Autism spectrum disorder (ASD) is characterized by significant social functioning impairments, including (but not limited to) emotion recognition, mentalizing, and joint attention. Despite extensive investigation into the correlates of social functioning in ASD, only recently has there been focus on the role of low-level sensory input, particularly visual processing. Extensive gaze deficits have been described in ASD, from basic saccadic function through to social attention and the processing of complex biological motion. Given that social functioning often relies on accurately processing visual information, inefficient visual processing may contribute to the emergence and sustainment of social functioning difficulties in ASD. To explore the association between measures of gaze and social functioning in ASD, a systematic review and meta-analysis was conducted. A total of 95 studies were identified from a search of CINAHL Plus, Embase, OVID Medline, and psycINFO databases in July 2021. Findings support associations between increased gaze to the face/head and eye regions with improved social functioning and reduced autism symptom severity. However, gaze allocation to the mouth appears dependent on social and emotional content of scenes and the cognitive profile of participants. This review supports the investigation of gaze variables as potential biomarkers of ASD, although future longitudinal studies are required to investigate the developmental progression of this relationship and to explore the influence of heterogeneity in ASD clinical characteristics. Lay SummaryThis review explored how eye gaze (e.g., where a person looks when watching a movie) is associated with social functioning in autism spectrum disorder (ASD). We found evidence that better social functioning in ASD was associated with increased eye gaze toward faces/head and eye regions. Individual characteristics (e.g., intelligence) and the complexity of the social scene also influenced eye gaze. Future research including large longitudinal studies and studies investigating the influence of differing presentations of ASD are recommended.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta‐analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Reaction times, accuracy and eye-movement data provide insight into participants’ emotion recognition abilities. ▶ Gap-Overlap task [ 74 ]: Participants view a centrally presented stimulus and then shift their attention to a peripheral stimulus presented randomly to either side. This task assesses the speed and accuracy of shifts of low-level overt attention .…”

Section: Methodsmentioning

confidence: 99%

Characterising illness stages and recovery trajectories of eating disorders in young people via remote measurement technology (STORY): a multi-centre prospective cohort study protocol

Kuehne,

Phillips,

Moody

et al. 2024

BMC Psychiatry

Self Cite

View full text Add to dashboard Cite

Background Eating disorders (EDs) are serious, often chronic, conditions associated with pronounced morbidity, mortality, and dysfunction increasingly affecting young people worldwide. Illness progression, stages and recovery trajectories of EDs are still poorly characterised. The STORY study dynamically and longitudinally assesses young people with different EDs (restricting; bingeing/bulimic presentations) and illness durations (earlier; later stages) compared to healthy controls. Remote measurement technology (RMT) with active and passive sensing is used to advance understanding of the heterogeneity of earlier and more progressed clinical presentations and predictors of recovery or relapse. Methods STORY follows 720 young people aged 16–25 with EDs and 120 healthy controls for 12 months. Online self-report questionnaires regularly assess ED symptoms, psychiatric comorbidities, quality of life, and socioeconomic environment. Additional ongoing monitoring using multi-parametric RMT via smartphones and wearable smart rings (‘Ōura ring’) unobtrusively measures individuals’ daily behaviour and physiology (e.g., Bluetooth connections, sleep, autonomic arousal). A subgroup of participants completes additional in-person cognitive and neuroimaging assessments at study-baseline and after 12 months. Discussion By leveraging these large-scale longitudinal data from participants across ED diagnoses and illness durations, the STORY study seeks to elucidate potential biopsychosocial predictors of outcome, their interplay with developmental and socioemotional changes, and barriers and facilitators of recovery. STORY holds the promise of providing actionable findings that can be translated into clinical practice by informing the development of both early intervention and personalised treatment that is tailored to illness stage and individual circumstances, ultimately disrupting the long-term burden of EDs on individuals and their families.

show abstract

“…The detection of co-occurring ASD among individuals with ID associated with known genetic conditions, such as DS, poses many challenges [32,33]. It is becoming increasingly apparent that individuals with DS are at increased risk for presenting with the symptoms ASD relative to the general population [5,6]; moreover, due to the developmental delays associated with the DS phenotype may influence the presentation of ASD symptomatology in this population [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Symptoms of Autism Spectrum Disorder in Individuals with Down Syndrome

et al. 2021

View full text Add to dashboard Cite

There is a growing body of evidence to suggest that individuals with Down syndrome (DS) are diagnosed with autism spectrum disorders (ASD) at a higher rate than individuals in the general population. Nonetheless, little is known regarding the unique presentation of ASD symptoms in DS. The current study aims to explore the prevalence and profiles of ASD symptoms in a sample of individuals with DS (n = 83), aged between 6 and 23 years. Analysis of this sample (MAge = 15.13) revealed that approximately 37% of the sample met the classification cut-off for ASD using the Autism Diagnostic Observation Schedule 2 (ADOS-2) Calibrated Severity Score (CSS), an indicator of the participants’ severity of ASD-related symptoms. Item-level analyses revealed that multiple items on Module 2 and Module 3 of the ADOS-2, mostly in the Social Affect (SA) subdomain, differentiated the children with DS who did not meet ASD classification (DS-only) from those who did (DS + ASD). Lastly, comparisons of individuals with DS-only and those with DS + ASD differed significantly on the syntactic complexity of their expressive language. These findings shed light on the unique presentation of ASD symptoms in a sample of individuals with DS and suggest that expressive language abilities may play a pivotal role in the presentation of ASD symptoms in DS.

show abstract

Visuo-attentional correlates of Autism Spectrum Disorder (ASD) in children with Down syndrome: A comparative study with children with idiopathic ASD

Abstract: Highlights Visuospatial orienting efficiency increases with symptom severity in idiopathic ASD. Children with Down syndrome and comorbid ASD display superior search performance. Visuo-spatial orienting ability and visual search performance appears unrelated.

Cited by 7 publications

References 73 publications

Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta‐analysis

Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta‐analysis

Characterising illness stages and recovery trajectories of eating disorders in young people via remote measurement technology (STORY): a multi-centre prospective cohort study protocol

Symptoms of Autism Spectrum Disorder in Individuals with Down Syndrome

Contact Info

Product

Resources

About