Visually induced activity in human frontal motor areas during simple visuomotor performance

Thut, Gregor; Hauert, Claude-Alain; Blanke, Olaf; Morand, S.; Seeck, Margitta; Gonzalez, Sara; Peralta, Rolando Grave de; Spinelli, Laurent; Khateb, Asaïd; Landis, T.; Michel, Christian

doi:10.1097/00001756-200009110-00004

Cited by 28 publications

(15 citation statements)

References 23 publications

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“…Although it might be expected that somatosensory processing would begin only after movement onset, recent studies have demonstrated that somatosensory processing can precede motor processing for a visuomotor task [Thut et al, 2000], either anticipating the to-be-received proprioceptive signal (efference copy) or using current body posture to model the to-beexecuted movement [Parsons et al, 1995]. As shown in Figure 2, primary somatosensory (S1) cortex activation (0 -100 msec) precedes M1 activation, and continued during M1 activation (100 -200 msec), but reached maximum after M1 activation (200 -300 msec).…”

Section: Resultsmentioning

confidence: 99%

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging

Xiong

Fox²,

Gao

2003

Human Brain Mapping

122

109

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Magnetic resonance imaging (MRI) of brain functional activity relies principally on changes in cerebral hemodynamics, which are more spatially and temporally distributed than the underlying neuronal activity changes. We present a novel MRI technique for mapping brain functional activity by directly detecting magnetic fields induced by neuronal firing. Using a well-established visuomotor paradigm, the locations and latencies of activations in visual, motor, and premotor cortices were imaged at a temporal resolution of 100 msec and a spatial resolution of 3 mm, and were found to be in consistent with the electrophysiological and functional MRI (fMRI) literature. Signal strength was comparable to traditional event-related fMRI methods: about 1% of the baseline signal. The magnetic-source MRI technique greatly increases the temporal accuracy in detecting neuronal activity, providing a powerful new tool for mapping brain functional organization in human and animals.

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Section: Resultsmentioning

confidence: 99%

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging

Xiong

Fox²,

Gao

2003

Human Brain Mapping

122

109

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show abstract

“…Times for stimuli presentation and TMS were chosen in order to explore the early cortical elaboration before the response generation. Previous EEG (Thut et al, 2000) and TMS singlepulse studies (Hoshiyama et al, 1997;Leocani, Cohen, Wassermann, Ikoma, & Hallett, 2000) employing visuo-motor tasks have shown the activation of the PMC-motor cortices 100Á200 ms after stimulus perception. Other studies employing go/no-go paradigms have shown the modulation of MEPs in the interval between Subjects were requested to press (go) or not to press (no-go) the space-bar of a PC keyboard on the basis of the colors presented on the pictures.…”

Section: Methodsmentioning

confidence: 95%

Release of premotor activity after repetitive transcranial magnetic stimulation of prefrontal cortex

Gangitano

Mottaghy

Pascual‐Leone

2008

Social Neuroscience

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In the present study we aimed to explore by means of repetitive transcranial magnetic stimulation (rTMS) the reciprocal influences between prefrontal cortex (PFC) and premotor cortex (PMC). Subjects were asked to observe on a computer monitor different pictures representing manipulations of different kind of tools. They had to produce a movement (go condition) or to keep the resting position (no-go condition) at the appearance of different cue signals represented by different colors shown alternatively on the hands manipulating the tools or on the picture background. Motor evoked potentials (MEPs) were collected at the offset of the visual stimuli before and after a 10 minute, 1 Hz rTMS train applied to the dorsolateral PFC (Experiment 1), to the PMC (Experiment 2) or to the primary motor cortex (Experiment 3). Following rTMS to the PFC, MEPs increased in the go condition when the cue for the go command was presented on the hand. In contrast, following rTMS to the PMC, in the same condition, MEPs were decreased. rTMS to the primary motor cortex did not produce any modulation. Results are discussed according to the presence of a visual-motor matching system in the PMC and to the role of the PFC in the attention-related processes. We hypothesize that the perceptual analysis for action selection within the PFC was modulated by rTMS and its temporary functional inactivation in turn influenced the premotor areas for motor programming

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“…ELECTRA provides estimates of the 3D distribution of LFPs within the whole brain, which facilitates its direct comparison with recordings from intracranial electrodes. The advantages and limitations of ELEC-TRA have been explored using simulations [Grave de Peralta Menendez et al, 2000], comparisons with intracranial recordings in a task similar to the one reported here [Thut et al, 2000], and localization of epileptic activity [Michel et al, 1999]. These studies have shown that a scale-independent waveshape analysis circumvents one basic limitation of distributed inverse solutions, i.e., the uncertainty estimating source amplitudes [Grave de Peralta Menendez and Gonzalez Andino, 1998].…”

Section: Discussionmentioning

confidence: 99%

Prediction of response speed by anticipatory high‐frequency (gamma band) oscillations in the human brain

Andino¹,

Michel²,

Thut³

et al. 2004

Human Brain Mapping

Self Cite

126

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Response to a stimulus is faster when a subject is attending and knows beforehand how to respond. It has been suggested recently that this occurs because ongoing neuronal activity is spatially and temporally structured during states of expectancy preceding a stimulus. This mechanism is believed to mediate top-down processing, facilitating the early grouping and selection of distributed neuronal ensembles implicated in ensuing sensory-motor processing. To validate this model, it must be shown that some features of this early ongoing neural activity are correlated with subsequent perceptual decisions or behavioral events. We investigated this hypothesis in an electrophysiologic study in 12 subjects carrying out a simple visuomotor reaction-time task. Local field potentials (LFP) at each brain voxel were estimated using a linear distributed inverse solution termed "ELECTRA" for each single trial of each subject. The energy of oscillations for different frequency bands was computed for the period between the warning cue and visual stimuli by applying a time-frequency decomposition to the estimated LFP. A nonparametric correlation coefficient was then calculated between energy of oscillations and reaction times for each single sweep. Gamma band oscillatory activity in a frontoparietal network before stimulus onset significantly correlated with reaction time for a significant amount of subjects. These results provide direct evidence for the role of neural oscillations as a top-down attentional control mechanism that mediates the speed of motor actions.

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Visually induced activity in human frontal motor areas during simple visuomotor performance

Cited by 28 publications

References 23 publications

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging

Directly mapping magnetic field effects of neuronal activity by magnetic resonance imaging

Release of premotor activity after repetitive transcranial magnetic stimulation of prefrontal cortex

Prediction of response speed by anticipatory high‐frequency (gamma band) oscillations in the human brain

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