Visually evoked blood flow responses and interaction with dynamic cerebral autoregulation: Correction for blood pressure variation

Gommer, Erik D.; Bogaarts, Guy; Martens, Esther; Mess, Werner H.; Reulen, J. P. H.

doi:10.1016/j.medengphy.2014.01.006

Cited by 11 publications

(8 citation statements)

References 28 publications

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“…Our present understanding of neurovascular coupling in humans is limited, and the available knowledge is generated from a small number of laboratories, using a variety of unstandardized assessments. [52][53][54][55][56][57][58][59][60][61][62][63] Although there is mechanistic insight provided by the isolated preparations of neurovascular coupling, 41 little is known about which mechanisms are sufficient versus necessary for a functional and effective neurovascular coupling response in humans. The available literature related to this topic is reviewed below.…”

Section: Human Neurovascular Couplingmentioning

confidence: 99%

Neurovascular coupling in humans: Physiology, methodological advances and clinical implications

Phillips

Chan

Zheng

et al. 2015

J Cereb Blood Flow Metab

337

364

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Neurovascular coupling reflects the close temporal and regional linkage between neural activity and cerebral blood flow. Although providing mechanistic insight, our understanding of neurovascular coupling is largely limited to nonphysiological ex vivo preparations and non-human models using sedatives/anesthetics with confounding cerebrovascular implications. Herein, with particular focus on humans, we review the present mechanistic understanding of neurovascular coupling and highlight current approaches to assess these responses and the application in health and disease. Moreover, we present new guidelines for standardizing the assessment of neurovascular coupling in humans. To improve the reliability of measurement and related interpretation, the utility of new automated software for neurovascular coupling is demonstrated, which provides the capacity for coalescing repetitive trials and time intervals into single contours and extracting numerous metrics (e.g., conductance and pulsatility, critical closing pressure, etc.) according to patterns of interest (e.g., peak/minimum response, time of response, etc.). This versatile software also permits the normalization of neurovascular coupling metrics to dynamic changes in arterial blood gases, potentially influencing the hyperemic response. It is hoped that these guidelines, combined with the newly developed and openly available software, will help to propel the understanding of neurovascular coupling in humans and also lead to improved clinical management of this critical physiological function.

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Section: Human Neurovascular Couplingmentioning

confidence: 99%

Neurovascular coupling in humans: Physiology, methodological advances and clinical implications

Phillips

Chan

Zheng

et al. 2015

J Cereb Blood Flow Metab

337

364

View full text Add to dashboard Cite

show abstract

“…Data from each trial were aligned to stimulus onset (eyes open command), then averaged to generate one response per subject, per testing session. As per previous research (30), the average of the 5 sec preceding initiation (i.e., the last 5 sec of eyes closed), are reported as the baseline CBV in both the PCA and MCA. The peak velocity observed in each respective vessel obtained during the 30 sec following the eyes open command is reported in both absolute and relative terms.…”

Section: Data Processingmentioning

confidence: 99%

An Acute Bout of Soccer Heading Subtly Alters Neurovascular Coupling Metrics

et al. 2020

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The current investigation examined how a bout of soccer heading may impact brain function. Design: Semi-randomized crossover cohort. Setting: Controlled soccer heading. Participants: Seven male soccer players (24.1 ± 1.5 years). Intervention: 40 successful soccer headers were performed in 20 min (25 m, launch velocity ∼80 km/h). X2 xPatch recorded linear and rotational head accelerations during each impact. A contact control "sham" condition-ball made body contact, but not by the head; and a no activity time "control" condition were also completed. Main Outcome Measures: Posterior and middle cerebral artery (PCA and MCA, respectively), cerebral blood velocity (CBV) was recorded during a visual task (neurovascular coupling: NVC) alongside SCAT3 symptoms scores pre/post a controlled bout of soccer heading. Results: Cumulative linear and rotational accelerations were 1,574 ± 97.9 g and 313,761 ± 23,966 rads/s 2 , respectively, during heading and changes in SCAT3 symptom number (pre: 2.6 ± 3.0; post: 6.7 ± 6.2, p = 0.13) and severity (pre: 3.7 ± 3.6, post: 9.4 ± 7.6, p = 0.11) were unchanged. In the PCA, no NVC differences were observed, including: relative CBV increase (28.0 ± 7.6%, p = 0.71) and total activation (188.7 ± 68.1 cm, p = 0.93). However, MCA-derived NVC metrics were blunted following heading, demonstrating decreased relative CBV increase (7.8 ± 3.1%, p = 0.03) and decreased total activation (26.7 ± 45.3 cm, p = 0.04).

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“…; Gommer et al. ). Significant rises in HR and MAP at task initiation have been demonstrated in a number of neuroactivation studies (Moody et al.…”

Section: Introductionmentioning

confidence: 96%

Neurovascular coupling response to cognitive examination in healthy controls: a multivariate analysis

et al. 2018

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Cognitive testing with transcranial Doppler ultrasonography (TCD) has been used to assess neurovascular coupling (NVC), but few studies address its multiple contributions. Subcomponent analysis considers the relative myogenic (resistance area product, RAP) and metabolic (critical closing pressure (CrCP)) contributors. The aim of this study was to investigate the changes in subcomponents that occur with cognitive stimulation with the Addenbrooke's Cognitive Examination (ACE‐III) in healthy controls. Healthy volunteers underwent continuous recording of bilateral TCD, heart rate (HR, three‐lead ECG), end‐tidal CO 2 (ETCO 2, capnography), and mean arterial pressure (MAP, Finometer). The study comprised a 5‐min baseline recording, followed by all 20 paradigms from the ACE‐III. The cerebral blood flow velocity (CBFv) response was decomposed into the relative contributions (subcomponents); V BP (MAP), V CrCP (CrCP), and V RAP (RAP). Data are presented as peak population normalized mean changes from baseline, and median area under the curve (AUC). Forty bilateral datasets were obtained (27 female, 37 right hand dominant). V BP increased at task initiation in all paradigms but differed between tasks (range (SD): 4.06 (8.92)–16.04 (12.23) %, P < 0.05). HR, but not ETCO 2, also differed significantly (P < 0.05). Changes in V RAP reflected changes in MAP, but in some paradigms atypical responses were seen. V CrCP AUC varied significantly within paradigm sections (range [SD]: 18.4 [24.17] to 244.21 [243.21] %*s, P < 0.05). All paradigms demonstrated changes in subcomponents with cognitive stimulation, and can be ranked based on their relative presumed metabolic demand. The integrity of NVC requires further investigation in patient populations.

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Visually evoked blood flow responses and interaction with dynamic cerebral autoregulation: Correction for blood pressure variation

Cited by 11 publications

References 28 publications

Neurovascular coupling in humans: Physiology, methodological advances and clinical implications

Neurovascular coupling in humans: Physiology, methodological advances and clinical implications

An Acute Bout of Soccer Heading Subtly Alters Neurovascular Coupling Metrics

Neurovascular coupling response to cognitive examination in healthy controls: a multivariate analysis

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