Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique

Kuroda, Hidekatsu; Abe, Tamami; Kakisaka, Keisuke; Fujiwara, Yoshitaka; Yoshida, Yasuhiko; Miyasaka, Akio; Ishida, Kazuyuki; Ishida, Hideaki; Sugai, Tamotsu; Takikawa, Yasuhiro

doi:10.3748/wjg.v22.i26.6057

Cited by 30 publications

(25 citation statements)

References 24 publications

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“…Previous reports have compared the utility of transabdominal US for microvascular imaging with that of conventional Doppler imaging for the diagnosis of several diseases [27][28][29][30][31][32]. Another microvascular imaging technique similar to DFI, super microvascular imaging, furnishes significantly more information about vascularity than conventional Doppler imaging, making it more suitable for the differential diagnosis of lesions of the breast, thyroid, liver, kidney, and cervical lymph nodes [27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…However, performing transabdominal US to assess microvessels is difficult if the patient is obese (due to the depth of subcutaneous fat). The increased distance between the deeper organs and the probe also has a negative effect on the clarity of the microvascular images [32]. Therefore, to date, no studies into the utility of transabdominal US for microvascular imaging of pancreatobiliary lesions have been reported.…”

Section: Discussionmentioning

confidence: 99%

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A Novel Endoscopic Ultrasonography Imaging Technique for Depicting Microcirculation in Pancreatobiliary Lesions without the Need for Contrast-Enhancement: A Prospective Exploratory Study

et al. 2021

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Detective flow imaging endoscopic ultrasonography (DFI-EUS) provides a new method to image and detect fine vessels and low-velocity blood flow without using ultrasound contrast agents. The aim of this study was to evaluate the utility of DFI-EUS for pancreatobiliary lesions and lymph nodes. Between January 2019 and January 2020, 53 patients who underwent DFI-EUS, e-FLOW EUS, and contrast-enhanced EUS were enrolled. The ability of DFI-EUS and e-FLOW EUS to detect vessels was compared with that of contrast-enhanced EUS. This article describes the DFI technique along with our first experience of its use for vascular assessment of pancreatobiliary lesions. Vessels were imaged in 34 pancreatic solid lesions, eight intraductal papillary mucinous neoplasms (IPMNs), seven gall bladder lesions, and four swollen lymph nodes. DFI-EUS (91%) was significantly superior to e-FLOW EUS (53%) with respect to detection of vessels (p < 0.001) and for discrimination of mural nodules from mucous clots in IPMN and gallbladder lesions from sludge (p = 0.046). Thus, DFI-EUS has the potential to become an essential tool for diagnosis and vascular assessment of various diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Novel Endoscopic Ultrasonography Imaging Technique for Depicting Microcirculation in Pancreatobiliary Lesions without the Need for Contrast-Enhancement: A Prospective Exploratory Study

et al. 2021

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“…At present, some new ultrasonic technologies have been applied in diagnosis of liver diseases, including superb microvascular imaging and ultrasound elastography, such as shear wave elastography, FibroScan, and acoustic radiation force impulse imaging. They can be helpful for noninvasive evaluation of fatty liver disease, liver fibrosis, and liver tumors [ 6 , 10 , 13 , 16 ]. In recent years, some other researchers have tried to analyze FL by ultrasound RF signals [ 2 , 9 , 18 , 22 ].These studies have revealed that there is a strong correlation between the pathology changes of FL and characteristics.…”

Section: Discussionmentioning

confidence: 99%

Grading fatty liver by ultrasound time-domain radiofrequency signal analysis: an <i>in vivo</i> study of rats

et al. 2018

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This study aimed to assess the severity of fatty liver (FL) by analyzing ultrasound radiofrequency (RF) signals in rats. One hundred and twenty rats (72 in the FL group and 48 in the control group) were used for this purpose. Histological results were the golden standard: 42 cases had normal livers (N), 30 cases had mild FL (L1), 25 cases had moderate FL (L2), 13 cases presented with severe FL (L3), and 10 cases were excluded from the study. Four RF parameters (Mean, Mean/SD ratio [MSR], skewness [SK], and kurtosis [KU] were extracted. Univariate analysis, spearman correlation analysis, and stepwise regression analysis were used to select the most powerful predictors. Receiver operating characteristic (ROC) analysis was used to compare the diagnostic efficacy of single indexes with a combined index (Y) expressed by a regression equation. Mean, MSR, SK, and KU were significantly correlated with FL grades (r=0.71, P<0.001; r=0.81, P<0.001; r=−0.79, P<0.001; and r=−0.74, P<0.001). The regression equation was Y=−4.48 + 3.20 × 10−2X1 + 3.15X2 (P<0.001), where Y=hepatic steatosis grade, X1 =Mean, and X2 =MSR. ROC analysis showed that the curve areas of the combined index (Y) were superior to simple indexes (Mean, MSR, SK, and KU) in evaluating hepatic steatosis grade, and they were 0.95 (L≥L1), 0.98 (L≥L2), and 0.99 (L≥L3). Ultrasound radiofrequency signal quantitative technology was a new, noninvasive, and promising sonography-based approach for the assessment of FL.

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“…Evaluating the morphologic characteristics of the vasculature at the edge of the liver is thought to be useful for assessing hepatic fibrosis; thus, some researchers investigated the use of SMI. Kuroda et al analyzed the number of vascular trees detected by SMI and found that SMI could aid the detailed delineation of the vascular architecture in hepatic fibrosis. Koyama et al assessed the vascular scores and bifurcation angle in the vasculature detected by SMI.…”

Section: Superb Microvascular Imaging For Characterization Of Liver Dmentioning

confidence: 99%

Clinical Applications of Superb Microvascular Imaging in the Liver, Breast, Thyroid, Skeletal Muscle, and Carotid Plaques

Jiang

Huang

Shen

et al. 2019

J of Ultrasound Medicine

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This article reviews the clinical applications of Superb Microvascular Imaging (SMI; Canon Medical Systems, Otawara, Japan) in the liver, breast, thyroid, skeletal muscle, and carotid plaques. Diseases that are closely associated with angiogenesis can be diagnosed by SMI in a relatively early phase, and using SMI can prevent adverse reactions associated with the contrast agents used in contrast‐enhanced ultrasound. Super Microvascular Imaging also shows particular value in grading disease activities and monitoring therapeutic responses. Although SMI has some limitations, such as a lack of clinical standards, it can add information to conventional ultrasound examinations and may become a noninvasive alternative to invasive diagnostic procedures for many clinical conditions.

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Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique

Abstract: SMI permitted the detailed delineation of the vascular architecture in chronic liver disease. SMI appears to be a reliable tool for noninvasively detecting significant fibrosis or cirrhosis in HCV patients.

Cited by 30 publications

References 24 publications

A Novel Endoscopic Ultrasonography Imaging Technique for Depicting Microcirculation in Pancreatobiliary Lesions without the Need for Contrast-Enhancement: A Prospective Exploratory Study

A Novel Endoscopic Ultrasonography Imaging Technique for Depicting Microcirculation in Pancreatobiliary Lesions without the Need for Contrast-Enhancement: A Prospective Exploratory Study

Grading fatty liver by ultrasound time-domain radiofrequency signal analysis: an <i>in vivo</i> study of rats

Clinical Applications of Superb Microvascular Imaging in the Liver, Breast, Thyroid, Skeletal Muscle, and Carotid Plaques

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