1998
DOI: 10.1080/10629369808039142
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Visualizing The Future of Molecular Graphics

Abstract: The field of computer graphics has played an important role in the advancement of structural molecular biology and in the development of structure-based drug design. This article will provide a brief background on the development of this technology, and then focus on the current trends and future directions in molecular graphics and how they will impact the practice of molecular modeling and design. Specific areas that will be covered include: 1) the development of surface and volume based representations of m… Show more

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Cited by 7 publications
(5 citation statements)
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References 36 publications
(26 reference statements)
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“…Molecular and genomic methods are anticipated to influence the direction of medical microbiology in the future. With these methods, infectious illness diagnoses can be made more quickly and precisely, which can lead to better patient outcomes [52,53]. Additionally, in light of the increasing prevalence of antibiotic resistance, molecular and genomic techniques can be used to discover bacterial strains that are resistant to antibiotics [54].…”
Section: Future Of Molecular and Genomic Approachesmentioning
confidence: 99%
“…Molecular and genomic methods are anticipated to influence the direction of medical microbiology in the future. With these methods, infectious illness diagnoses can be made more quickly and precisely, which can lead to better patient outcomes [52,53]. Additionally, in light of the increasing prevalence of antibiotic resistance, molecular and genomic techniques can be used to discover bacterial strains that are resistant to antibiotics [54].…”
Section: Future Of Molecular and Genomic Approachesmentioning
confidence: 99%
“…These can be red independently from the rest of the manuscript. We refer to the literature for more thoroughly reviews on the more technical aspects of molecular visualization (1,2,3,4,5,6,7,8,9,10). Also, the large number of visualization tools will not be reviewed or compared.…”
Section: Overview Of the Drug Design Processmentioning
confidence: 99%
“…Chem Biol Drug Des 2006; 67: [5][6][7][8][9][10][11][12]to be in the 'native binding mode,' the R1 groups are expected to interact with the hydrophobic pocket of p38. The R2 portion of 1ouk-inh, on the other hand, is positioned in the vicinity of the adenine-binding site in the hinge region, whereas the R3 group interacts with the phosphate-binding region (P-loop).…”
Section: Structural Interaction Fingerprintsmentioning
confidence: 99%
“…For example, LIGPLOT generates twodimensional (2D) schematics of protein-small molecule complexes that describe the intermolecular interactions including the strengths of hydrogen bonds and hydrophobic interactions [5]. In addition to 2D approaches, a variety of sophisticated computer graphics programs such as InsightII (Accelrys Inc., Burlington, MA, USA), VIDA (Open Eye, Cambridge, MA, USA), Sybyl (Tripos Inc., St Louis, MO, USA), and Maestro (Schrodinger Inc., New York, NY, USA) are available for analyzing the 3D structure of proteins and their complexes [6]. Although these 2D and 3D approaches are useful when examining small numbers of structures, the analysis of large datasets is not feasible.…”
mentioning
confidence: 99%