Visualizing the cerebral distribution of chemical elements: A challenge met with LIBS elemental imaging

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

“…In a short communication by Busser et al , 188 LIBS was implemented for elemental imaging of brain tissue for endogenous Zn and NPs . For Zn, quantitative data was obtained using doped resin standards, achieving a LOD of 2 ppm and R 2 of 0.9995.…”

Laser-Induced Breakdown Spectroscopy Imaging for Material and Biomedical Applications: Recent Advances and Future Perspectives

“…109676. Copyright 2022, with permission from Elsevier (ref ). (c) Nanoscale LIBS imaging of InP nanoparticles within single cells.…”

“…However, LIBS imaging was not included in the list despite being a method of choice for imaging brain tissues. Yet, LIBS may be very effective and helpful for researchers specializing in both nanomedicine and neurology . The visualization of endogenous chemical elements, such as P, Mg, Ca, Na, Cu, and Fe, was easily achieved with LIBS.…”

“…Yet, LIBS may be very effective and helpful for researchers specializing in both nanomedicine and neurology. 127 The visualization of endogenous chemical elements, such as P, Mg, Ca, Na, Cu, and Fe, was easily achieved with LIBS. The corresponding chemical maps described the localization of these elements of interest in animal brain cryosections obtained from adults and even from mouse embryos.…”

Artificial neural network for high-throughput spectral data processing in LIBS imaging: application to archaeological mortar

“…4,5 All these aspects make LIBS imaging a technique with a high elemental imaging potential in various elds such as biology, medicine, geology and industry. [6][7][8][9] However, the large number of spectra (>million in some cases) contained in an imaging dataset and the spectral complexity make this task difficult, in particular when certain elements (i.e., iron or titanium) are present. It becomes even a crucial issue when high throughput analysis at high speed is foreseen.…”