Visualizing semipermeability of the cell membrane using a pH-responsive ratiometric AIEgen

Gu, Yuan; Zhao, Zheng; Niu, Guangle; Zhang, Han; Wang, Yiming; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Tang, Ben Zhong

doi:10.1039/d0sc02097d

Cited by 33 publications

(16 citation statements)

References 40 publications

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“…The compound 52 showed fluorescence enhancement under viscous conditions and crystal states and exhibited dramatic emission wavelength changes from 454 to F I G U R E 9 Chemical structures of different heterocyclic AIEgens and effect of different substituents as rotors and recognition sites for their prospective use for bioapplications 511 nm in the pH range of 7-10. [86] Considering the conformational similarity of 52 to 51, the AIE performance was also caused by the RIV. The ion trapping phenomenon was visualized in live cells using the pH-dependent ratiometric fluorescence changes of 52.…”

Section: Heterocycles As Aiegensmentioning

confidence: 99%

Recent trends in molecular aggregates: An exploration of biomedicine

et al. 2022

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Molecular aggregates are receiving tremendous attention, demonstrating immense potential for biomedical applications in vitro and in vivo. For instance, the molecular aggregates of conventional fluorophores influence the electronic excitation states of the aggregates, causing characteristic photophysical property changes. A fundamental understanding of this classical relationship between molecular aggregate structures and photophysics has allowed for innovative biological applications. The chemical characteristics of drug molecules generally trigger the formation of colloidal aggregates, and this is considered detrimental to the drug discovery process. Furthermore, nano-sized supramolecular aggregates have been used in biomedical imaging and therapy owing to their optimal properties for in vivo utility, including enhanced cell permeability, passive tumor targeting, and convenient surface engineering. Herein, we provide an overview of the recent trends in molecular aggregates for biomedical applications. The changes in photophysical properties of conventional fluorophores and their biological applications are discussed, followed by the effects of conventional drug molecule-aggregates on drug discovery and therapeutics development. Recent trends in the investigation of biologically important analytes with aggregation-induced emission are discussed for conventional and unconventional fluorophores. Lastly, we discuss nano-sized supramolecular aggregates used in imaging and therapeutic purposes, with a focus on in vivo utilization.

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Section: Heterocycles As Aiegensmentioning

confidence: 99%

Recent trends in molecular aggregates: An exploration of biomedicine

et al. 2022

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“…• Gu et al . [ 44 ] developed a fluorescent probe based on dihydroberberine that showed that ionized berberine had a substantially lower cell penetration than the non-ionized form.…”

Section: Relationship Between Deregulated Ph and Mdrmentioning

confidence: 99%

The complex relationship between multiple drug resistance and the tumor pH gradient: a review

Koltai¹

2022

Cancer Drug Resist

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Multiple drug resistance (MDR) is the tumor’s way of escaping the cytotoxic effects of various unrelated chemotherapeutic drugs. It can be either innate or acquired. MDR represents the end of the therapeutic pathway, and it practically leaves no treatment alternatives. Reversing MDR is an unfulfilled goal, despite the important recent advances in cancer research. MDR, the main cause of death in cancer patients, is a multi-factorial development, and most of its known causes have been thoroughly discussed in the literature. However, there is one aspect that has not received adequate consideration - intracellular alkalosis - which is part of wider pH deregulation where the pH gradient is inverted, meaning that extracellular pH is decreased and intracellular pH increased. This situation interacts with MDR and with the proteins involved, such as P-gp, breast cancer resistance protein, and multidrug associated resistance protein 1. However, there are also situations in which these proteins play no role at all, and where pH takes the lead. This is the case in ion trapping. Reversing the pH gradient to normal can be an important contribution to managing MDR. The drugs to manipulate pH exist, and most of them are FDA approved and in clinical use for other purposes. Furthermore, they have low or no toxicity and are inexpensive compared with any chemotherapeutic treatment. Repurposing these drugs and combining them in a reasonable fashion is one of the points proposed in this paper, which discusses the relationship between cancer’s peculiar pH and MDR.

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“…Moreover, in recent years, some sustainable natural materials have attracted more and more attention. These materials have been widely applied in the field of biomedicine; however, their fluorescence characteristics have got little attention . In this work, an AIE polysaccharide with the CTE mechanism which comes from natural resources, oat-β-Glu, is found.…”

Section: Introductionmentioning

confidence: 99%

Seeking Aggregation-Induced Emission Materials in Food: Oat β-Glucan and Its Diverse Applications

Cao

Zhong

et al. 2021

J. Agric. Food Chem.

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With the basic understanding and broad application prospects of luminescent materials, the emission mechanism of unconventional luminescent agents has been revealed gradually. Here, we report a non-conjugated biomass material, oat β-glucan (oat-β-Glu), which actually does not emit light in a dilute solution but emits significantly when forming aggregates. Inherently visible emission of oat-β-Glu from the concentrated solutions and solid state could be observed. In addition, we have observed room temperature phosphorescence in oat-β-Glu powders, which is also unusual in pure organic materials. It can be proposed that the luminescence property of oat-β-Glu originates from the spatial conjugation of the oxygen atoms of oat-β-Glu. This clustering-triggered emission mechanism may well be expanded to other unconventional biomacromolecules, inspiring the rational design of luminescent agents. Due to its good biocompatibility and intrinsic emission characteristics, oat-β-Glu has shown great potential application prospects in bioimaging and biosensors.

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Visualizing semipermeability of the cell membrane using a pH-responsive ratiometric AIEgen

Abstract: By utilizing a pH-responsive ratiometric AIEgen, dihydro berberine (dhBBR), ion trapping phenomenon was successfully visualized.

Cited by 33 publications

References 40 publications

Recent trends in molecular aggregates: An exploration of biomedicine

Recent trends in molecular aggregates: An exploration of biomedicine

The complex relationship between multiple drug resistance and the tumor pH gradient: a review

Seeking Aggregation-Induced Emission Materials in Food: Oat β-Glucan and Its Diverse Applications

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