Visualizing molecular machines in action

Scheres, Sjors H.W.

doi:10.1016/b978-0-12-381357-2.00004-9

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Structural Heterogeneity1

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2011

2021

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Cited by 7 publications

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“…Crystallography relies on a very low degree of heterogeneity among the many molecules in their unit cells. As one gets to larger structures, one can find a greater range of conformational variations in macromolecules; one can sort for a number of these variations in single particle electron microscopy [52,53,54,55]. Individual variations are seen in the interiors of larger viruses (see for example [43,44]), and by the time one reaches the length scale of bacteria and especially with eukaryotic cells, one has a large degree of structural heterogeneity.…”

Section: Structural Heterogeneitymentioning

confidence: 99%