Visualization Techniques for the Developing Chicken Heart

Phan, Ly; Grimm, Cindy; Rugonyi, Sandra

doi:10.1007/978-3-319-27857-5_4

Cited by 3 publications

(3 citation statements)

References 53 publications

(67 reference statements)

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“…Briefly, the algorithm allowed extraction of OFT lumen and myocardium surfaces as a sequence of meshes over time during the cardiac cycle. To improve analysis of wall motion and facilitate volumetric mesh generation for CFD modeling, we implemented a consistent mesh parameterization strategy followed by a strain minimization algorithm [ 33 , 34 ]. The parameterization discretized the tubular lumen and myocardium surfaces using a cylindrical-like approach: with quasi cross-sectional planes intersecting the surfaces and defining contours (“rings”) along the OFT that were in turn uniformly discretized.…”

Section: Methodsmentioning

confidence: 99%

Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

Chivukula

Goenezen

Liu

et al. 2015

JCDD

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We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion in the OFT are affected by banding in ways that might not be intuitive a priori. In addition to the expected increase in ventricular blood pressure, and increase blood flow velocity and, thus, wall shear stress (WSS) at the band site, the characteristic peristaltic-like motion of the OFT was altered, further affecting flow and WSS. Myocardial contractility, however, was affected only close to the band site due to the physical restriction on wall motion imposed by the band. WSS were heterogeneously distributed in both normal and banded OFTs. Our results show how banding affects cardiac mechanics and can lead, in the future, to a better understanding of mechanisms by which altered blood flow conditions affect cardiac development leading to congenital heart disease.

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Section: Methodsmentioning

confidence: 99%

Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

Chivukula

Goenezen

Liu

et al. 2015

JCDD

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“…In OCT imaging, back-scattered light is measured up to 1–2 mm depth in cardiac tissue [ 87 , 88 ]. OCT is a non-invasive, non-contact, and high-resolution imaging technique during the embryonic development [ 89 , 90 , 91 ]. Echocardiography is an ultrasound based imaging method, enabling to image the heart and measure the blood flow rates at specific locations in real time.…”

Section: Chicken Embryo Modelsmentioning

confidence: 99%

Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease

Salman

Yalcin

2021

JCDD

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The heart is the first functional organ in a developing embryo. Cardiac development continues throughout developmental stages while the heart goes through a serious of drastic morphological changes. Previous animal experiments as well as clinical observations showed that disturbed hemodynamics interfere with the development of the heart and leads to the formation of a variety of defects in heart valves, heart chambers, and blood vessels, suggesting that hemodynamics is a governing factor for cardiogenesis, and disturbed hemodynamics is an important source of congenital heart defects. Therefore, there is an interest to image and quantify the flowing blood through a developing heart. Flow measurement in embryonic fetal heart can be performed using advanced techniques such as magnetic resonance imaging (MRI) or echocardiography. Computational fluid dynamics (CFD) modeling is another approach especially useful when the other imaging modalities are not available and in-depth flow assessment is needed. The approach is based on numerically solving relevant physical equations to approximate the flow hemodynamics and tissue behavior. This approach is becoming widely adapted to simulate cardiac flows during the embryonic development. While there are few studies for human fetal cardiac flows, many groups used zebrafish and chicken embryos as useful models for elucidating normal and diseased cardiogenesis. In this paper, we explain the major steps to generate CFD models for simulating cardiac hemodynamics in vivo and summarize the latest findings on chicken and zebrafish embryos as well as human fetal hearts.

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“…We present a methodology to establish point-to-point correspondence between AAA surfaces from the same patient obtained at two (or more) time points as part of surveillance. To the best of our knowledge, the work in this paper is the first attempt to obtain correspondence (also known as shape registration or shape parameterization) between AAA surfaces, and is based on our previous work on embryonic cardiac registration [21,22]. AAA surfaces are characterized by their cylindrical-like shape but generally lack salient features to guide the correspondence.…”

Section: Introductionmentioning

confidence: 99%

A Geodesics-Based Surface Parameterization to Assess Aneurysm Progression

Phan

Courchaine

Azarbal

et al. 2016

Journal of Biomechanical Engineering

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Abdominal aortic aneurysm (AAA) intervention and surveillance is currently based on maximum transverse diameter, even though it is recognized that this might not be the best strategy. About 10% of patients with small AAA transverse diameters, for whom intervention is not considered, still rupture; while patients with large AAA transverse diameters, for whom intervention would have been recommended, have stable aneurysms that do not rupture. While maximum transverse diameter is easy to measure and track in clinical practice, one of its main drawbacks is that it does not represent the whole AAA and rupture seldom occurs in the region of maximum transverse diameter. By following maximum transverse diameter alone clinicians are missing information on the shape change dynamics of the AAA, and clues that could lead to better patient care. We propose here a method to register AAA surfaces that were obtained from the same patient at different time points. Our registration method could be used to track the local changes of the patient-specific AAA. To achieve registration, our procedure uses a consistent parameterization of the AAA surfaces followed by strain relaxation. The main assumption of our procedure is that growth of the AAA occurs in such a way that surface strains are smoothly distributed, while regions of small and large surface growth can be differentiated. The proposed methodology has the potential to unravel different patterns of AAA growth that could be used to stratify patient risks.

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Visualization Techniques for the Developing Chicken Heart

Cited by 3 publications

References 53 publications

Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics

Computational Modeling of Blood Flow Hemodynamics for Biomechanical Investigation of Cardiac Development and Disease

A Geodesics-Based Surface Parameterization to Assess Aneurysm Progression

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