Visualization of White Matter Fiber Tracts of Brain Tissue Sections With Wide-Field Imaging Mueller Polarimetry

Schucht, Philippe; Lee, Hee Ryung; Mezouar, Hachem Mohammed; Hewer, Ekkehard; Raabe, Andreas; Murek, Michael; Zubak, Irena; Goldberg, Johannes; Kovari, Eniko Veronika; Pierangelo, Angelo; Novikova, Tatiana

doi:10.1109/tmi.2020.3018439

Cited by 62 publications

(66 citation statements)

References 49 publications

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“…It has been demonstrated that brain tissue with AD exhibits higher inhomogeneity of refractive index, higher scattering coefficient, higher birefringence due to parallel alignment of fibrils in Aβ plaques and higher anisotropy of scattering [14], [15], [18]. In the previous studies, it has been demonstrated that polarimetrybased techniques have a high potential to implement the labelfree, non-destructive express screening of brain tissues in order to facilitate the research on AD diagnostics and treatment [19]- [21].…”

mentioning

confidence: 99%

Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model

Borovkova

Sieryi

Lopushenko

et al. 2022

IEEE Trans. Med. Imaging

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mentioning

confidence: 99%

Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model

Borovkova

Sieryi

Lopushenko

et al. 2022

IEEE Trans. Med. Imaging

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“…It was shown that the wide-field imaging Mueller polarimetry in backscattering configuration provides high contrast images and highlights tissue microarchitecture 22 , 36 or pathological zones 37 – 40 that are not visible in the unpolarized intensity images. An imaging Mueller polarimeter integrates the signal over the volume of the probed tissue.…”

Section: Discussionmentioning

confidence: 99%

Mueller matrix imaging for collagen scoring in mice model of pregnancy

Lee

Saytashev

et al. 2021

Sci Rep

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Preterm birth risk is associated with early softening of the uterine cervix in pregnancy due to the accelerated remodeling of collagen extracellular matrix. Studies of mice model of pregnancy were performed with an imaging Mueller polarimeter at different time points of pregnancy to find polarimetric parameters for collagen scoring. Mueller matrix images of the unstained sections of mice uterine cervices were taken at day 6 and day 18 of 19-days gestation period and at different spatial locations through the cervices. The logarithmic decomposition of the recorded Mueller matrices mapped the depolarization, linear retardance, and azimuth of the optical axis of cervical tissue. These images highlighted both the inner structure of cervix and the arrangement of cervical collagen fibers confirmed by the second harmonic generation microscopy. The statistical analysis and two-Gaussians fit of the distributions of linear retardance and linear depolarization in the entire images of cervical tissue (without manual selection of the specific regions of interest) quantified the randomization of collagen fibers alignment with gestation time. At day 18 the remodeling of cervical extracellular matrix of collagen was measurable at the external cervical os that is available for the direct optical observations in vivo. It supports the assumption that imaging Mueller polarimetry holds promise for the fast and accurate collagen scoring in pregnancy and the assessment of the preterm birth risk.

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“…In general, total DOP can be derived from the components of the corresponding Stokes vector. However, in some cases, the determination of all elements of the Stokes vector is redundant [29] and using other polarization states would significantly complicate the system and its ability to be used in in vivo clinical conditions [45]- [47]. The system was equipped with a rotating linear polarizer, which can be placed either parallel or perpendicular to the initial polarization of the light source.…”

Section: A Hyperspectral Imaging Systemmentioning

confidence: 99%

Skin Complications of Diabetes Mellitus Revealed by Polarized Hyperspectral Imaging and Machine Learning

Dremin

Marcinkevičs

Zherebtsov

et al. 2021

IEEE Trans. Med. Imaging

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Visualization of White Matter Fiber Tracts of Brain Tissue Sections With Wide-Field Imaging Mueller Polarimetry

Cited by 62 publications

References 49 publications

Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model

Screening of Alzheimer’s Disease With Multiwavelength Stokes Polarimetry in a Mouse Model

Mueller matrix imaging for collagen scoring in mice model of pregnancy

Skin Complications of Diabetes Mellitus Revealed by Polarized Hyperspectral Imaging and Machine Learning

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