Visualization of the pH-fluctuations in gastric ulcer living mice by the in situ near-infrared imaging

Ma, Yanyan; Liu, Yongyuan; Jiang, Zike; Lv, Hongmin; Wang, Jing; Wang, Tao; Zhang, Xiaonan; Hu, Yimeng; Lin, Haitao; Lin, Weiying

doi:10.1016/j.snb.2021.130747

Cited by 17 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…36,37 Such a change in the pH value of the simulated gastric fluid is normal for in vitro study, similar to those reported in literature. 18,38 Apart from the digestion of gluten, swelling can also affect the resistance of GP. A control experiment was carried out by immersing a GP sample into an enzyme-free fluid of pH 2.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Fully Organic Sensors for Continuous Real-Time Digestion Monitoring

Zhou,

Ponraj,

Sun

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Section: ■ Results and Discussionmentioning

confidence: 99%

Fully Organic Sensors for Continuous Real-Time Digestion Monitoring

Zhou,

Ponraj,

Sun

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

“…These gastric pH changes are consistent with those expected during normal digestion. [5,14] Clinically, it has been difficult to monitor realtime changes in gastric pH, which is also affected by the presence or absence of food in the stomach. Standard clinical assessment still relies on invasive endoscopic tests or gastric juice extraction, which are invasive and cause significant patient discomfort, and are not suitable for long-term monitoring.…”

Section: In Vivo Ph Imaging and Quantitative Analysismentioning

confidence: 99%

“…[ 3 ] To solve these problems, non‐invasive techniques have been explored to monitor stomach pH, such as ingestible electronic capsules [ 4 ] and organic dye. [ 5 ] However, due to the limited tissue penetration depth of the probes used, these techniques still require endoscopy or ex vivo analyses to assist the optical measurements. [ 6 ] There remains an imminent need to develop a simple, safe, efficient, and accurate non‐invasive bioimaging method for assessing pH, with one of its applications being in vivo gastrointestinal pH detection in physiological and pathological studies.…”

Section: Introductionmentioning

confidence: 99%

Fe‐Doped Carbon Dots as NIR‐II Fluorescence Probe for In Vivo Gastric Imaging and pH Detection

Wang

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Carbon dots (CDs) with excellent cytocompatibility, tunable optical properties, and simple synthesis routes are highly desirable for use in optical bioimaging. However, the majority of existing CDs are triggered by ultraviolet/blue light, presenting emissions in the visible/first near‐infrared (NIR‐I) regions, which do not allow deep tissue penetration. Emerging research into CDs with NIR‐II emission in the red region has generated limited designs with poor quantum yield, restricting their in vivo imaging applications due to low penetration depth. Developing novel CDs with NIR‐II emissions and high quantum yield has significant and far‐reaching applications in bioimaging and photodynamic therapy. Here, it is developed for the first time Fe‐doped CDs (Fe‐CDs) exhibiting the excellent linear relationship between 900–1200 nm fluorescence‐emission and pH values, and high quantum yield (QY‐1.27%), which can be used as effective probes for in vivo NIR‐II bioimaging. These findings demonstrate reliable imaging accuracy in tissue as deep as 4 mm, reflecting real‐time pH changes comparable to a standard pH electrode. As an important example application, the Fe‐CDs probe can non‐invasively monitor in vivo gastric pH changes during the digestion process in mice, illustrating its potential applications in aiding imaging‐guided diagnosis of gastric diseases or therapeutic delivery.

show abstract

“…Abundant pepsin in the gastric fluid can also affect the theranostics of gastric diseases because it tends to degrade or bind to the theranostic reagents nonspecifically. Many gastric diseases are highly correlated with abnormal pH, and in situ pH monitoring is therefore indispensable for prevention and treatment of gastric diseases (Ma et al, 2021a). To realize accurate and interference-free MRI detection of gastric pH, Xu et al (2021) developed an orally administrated hydrogel capsule isolated human serum albumin−manganese (HSA-Mn) complex system, which could shield the interference of the pepsin in gastric fluid without severely hindering the penetration of H + , for sensitive MRI monitoring of gastric pH in vivo (Figure 2C).…”

Section: Theranostics In Harsh Stomach Conditionsmentioning

confidence: 99%

Metal Graphitic Nanocapsules for Theranostics in Harsh Conditions

Yang

et al. 2022

Front. Chem.

View full text Add to dashboard Cite

Metal nanoparticles (NPs) with superior physicochemical properties and biocompatibility have shown great potential in theranostics. However, metal NPs show poor stability in some harsh conditions such as strong acid, oxidation, corrosion and high-temperature conditions, which limits their extensive bioapplications. To address such issue, a variety of superstable metal graphitic nanocapsules with the metal cores confined in the nanospace of few-layer graphitic shell have been developed for biodetection and therapy in harsh conditions. In this mini-review, we summarize the recent advances in metal graphitic nanocapsules for bioapplications in harsh conditions. Firstly, their theranostic performance in non-intrinsic physiological harsh environment, including oxidation, corrosion and high-temperature conditions, is systematically discussed. Then, we highlight their theranostic performance in the harsh stomach condition that is strong acidic and pepsin-rich. It is expected that this review will offer inspiration to facilitate the exploitation of novel theranostic agents that are stable in harsh conditions.

show abstract

Visualization of the pH-fluctuations in gastric ulcer living mice by the in situ near-infrared imaging

Cited by 17 publications

References 35 publications

Fully Organic Sensors for Continuous Real-Time Digestion Monitoring

Fully Organic Sensors for Continuous Real-Time Digestion Monitoring

Fe‐Doped Carbon Dots as NIR‐II Fluorescence Probe for In Vivo Gastric Imaging and pH Detection

Metal Graphitic Nanocapsules for Theranostics in Harsh Conditions

Contact Info

Product

Resources

About