Visualization of the Oxygenation State of Brain and Muscle in Newborn Infants by Near Infra-Red Transillumination

Arridge, Simon; Cope, M; Zee, Pieter van der; Hillson, P. J.; Delpy, David T.

doi:10.1007/978-94-009-4261-5_12

Cited by 15 publications

(8 citation statements)

References 19 publications

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“…It was realized quite early on (Arridge et al, 1986) that NIRS measurements at multiple locations combined with image reconstruction algorithms can, in principle, be used for near infrared imaging, so that cerebral hemodynamic changes could be mapped in three dimensions. However, in spite of a significant amount of theoretical work (Boas et al, 2004a,b;Boas and Dale, 2005;Guven et al, 2005;Li et al, 2005;Xu et al, 2005), the literature on practical three dimensional fNIRSI of the human brain is limited to a few papers (Bluestone et al, 2001;Boas et al, 2004b;Hintz et al, 2001;Hoshi et al, 2000;Zhang et al, 2005a,b).…”

Section: Introductionmentioning

confidence: 99%

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

2007

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Functional near infrared spectro-imaging (fNIRSI) is potentially a very useful technique for obtaining information about the underlying physiology of the blood oxygenation level dependent (BOLD) signal used in functional magnetic resonance imaging (fMRI). In this paper the temporal and spatial statistical characteristics of fNIRSI data are compared to those of simultaneously acquired fMRI data in the human visual cortex during a variable-frequency reversing checkerboard activation paradigm. Changes in the size of activated volume caused by changes in checkerboard reversal frequency allowed a comparison of the behavior of the spatial responses measured by the two imaging methods. fNIRSI and fMRI data were each analyzed using standard correlation and fixed-effect group analyses of variance pathways. The statistical significance of fNIRSI data was found to be much lower than that of the fMRI data, due mainly to the low signal-to-noise of the measurements. Reconstructed images also showed that, while the time-course of changes in the oxy-, deoxy-, and total hemoglobin concentrations all exhibit high correlation with that of the BOLD response, the changes in the volume of tissue measured as "activated" by the BOLD response demonstrate a closer similarity to the corresponding changes in the oxy-and total hemoglobin concentrations than to that of the deoxyhemoglobin.

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Section: Introductionmentioning

confidence: 99%

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

2007

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“…The problem of tomographic reconstruction of absorption and scattering parameters in the optical region as applied to medical imaging has received considerable attention over the past few years. [1][2][3][4][5][6][7][8][9][10][11][12] The interest is a natural consequence of the highly successful application of transillumination in the near infrared to spectroscopic studies. [13][14][15][16][17][18][19] A variety of experimental techniques are employed to obtain the information used for both spectroscopic quantitation and imaging.…”

Section: Introductionmentioning

confidence: 99%

Photon-measurement density functions Part I: Analytical forms

1995

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This paper addresses the problem of tomographic reconstruction of absorption and scattering parameters in the optical region from measurements of transilluminated light. Specifically, the question of the sensitivity of different measurement schemes on the boundary of an object to perturbations of the optical parameters within the object are addressed. The concept of a photon-sampling volume [Appl. Opt. 33, 448 (1994)] and a photon-hitting density [Appl. Opt. 32, 448 (1993)] is extended to a photon-measurement density function (PMDF). The PMDF is derived from the Green's function of the diffusion equation and can be expressed for measurements such as the time-varying intensity, integrated intensity, temporal moments, and phase shift, as well as for both absorption and diffusion perturbations. Closed-form solutions are given for a number of these functions in infinite space, half-space, and slab geometries. Example results are given in terms of three-dimensional images.

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“…(6). But it is not necessary to calculate the gradient of the fluence rate at the surface, because it is given by half of the fluence rate at the surface as seen from the boundary condition (5).…”

Section: Solving Photon Diffusion Equation By Femmentioning

confidence: 99%

<title>Time-dependent FEM analysis of photon migration in random media</title>

Yamada

Hasegawa

1993

SPIE Proceedings

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Time-resolved spectroscopy is expected to be developed for imaging of buried absorbers inside strongly scattering media. It is highly required to know the temporal behaviors of the reflectance and/or transmittance produced by the propagation of light impulse incident on scattering and absorbing media. The Monte Carlo method (MC) is the most frequently used numerical method, but its computation time is considerably long to obtain the results with a satisfactory accuracy. A faster numerical method is required for analysis of temporal profiles of reflectance and transmittance through random media with complicated configurations. One of the methods is Finite Element method (FEM) to solve the photon diffusion equation numerically. This paper reports the FEM results of temporal profiles of transmittance of light impulse through scattering slabs and cylinders. Time courses of transmittances through homogeneously scattering and absorbing slabs are obtained by FEM and compared with those by MC. The results of cylinders with homogeneous scattering and inhomogeneous absorption coefficients are also presented. Temporal variations of the cross-sectional profiles of the fluence rate generated by impulse incident on a surface are shown by contour plotting, and the effect of the location and size of the localized absorbing volume on the transmittances are discussed.

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Visualization of the Oxygenation State of Brain and Muscle in Newborn Infants by Near Infra-Red Transillumination

Cited by 15 publications

References 19 publications

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

A spatial and temporal comparison of hemodynamic signals measured using optical and functional magnetic resonance imaging during activation in the human primary visual cortex

Photon-measurement density functions Part I: Analytical forms

<title>Time-dependent FEM analysis of photon migration in random media</title>

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