Visualization of the Lamina Cribrosa Using Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

Lee, Eun Ji; Kim, Tae Woo; Weinreb, Robert N.; Park, Ki Ho; Kim, Seok Hwan; Kim, Dong‐Myung

doi:10.1016/j.ajo.2011.01.024

Cited by 179 publications

(136 citation statements)

References 31 publications

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“…[17][18][19] The current study showed that SS-OCT at 1050 nm allowed 3D imaging of the whole lamina structures including the structure beneath the neuroretinal rim. Lamina cribrosa defects were thus found only by the EDI-OCT (in earlier studies) 20,21 and SS-OCT at 1050 nm (current study), probably because they were located at or in the vicinity of the lamina cribrosa margins beneath the neuroretinal rim.…”

Section: Discussionmentioning

confidence: 99%

“…14,16 SD-OCT technology also allows enhanced depth imaging (EDI), which improves visualization of the deep fundus structures including the lamina cribrosa. [17][18][19] Recently, the EDI-OCT method was successfully used in the discovery of a local abnormality of lamina cribrosa, termed focal lamina cribrosa defect, which was associated with local glaucomatous optic disc changes such as neuroretinal rim thinning/notching or acquired pits of the optic nerve (APONs). 20,21 This interesting feature has not been reported in the earlier histopathological articles on glaucomatous eyes.…”

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confidence: 99%

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Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Takayama

Hangai

Kimura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Takayama

Hangai

Kimura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…Enhanced depth imaging (EDI) technology has led to a revolution in the study of deeper eye structures, such as the choroid and the LC. [4][5][6] It allows visualisation of the LC underneath the neuroretinal ring and provides high resolution images similar to those obtained by histology. This technique has been used to evaluate the LC in both normal and glaucomatous subjects.…”

Section: Introductionmentioning

confidence: 98%

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Barrancos

Rebolleda

Oblanca

et al. 2013

Eye

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Aim To determine the response of the lamina cribrosa (LC) and prelaminar tissue to a reduction of intraocular pressure (IOP) after nonpenetrating deep sclerectomy (NPDS) using enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods A total of 28 eyes from 28 patients presenting with primary open angle glaucoma who underwent NPDS were studied. SD-OCT scans using EDI technology were obtained before surgery and 1 week, 1 month, and 3 months postoperatively. The OCT device was set to image a 15 Â 101 vertical rectangle centred on the optic disc. The scan closest to the optic nerve head (ONH) centre was selected for analysis. The vertical distances from three equidistant points on the reference line (Bruch's membrane opening) to the anterior prelaminar tissue surface and the anterior and posterior surfaces of the LC were measured. Results The IOP decreased from 18.7 ± 4.3 to 9.1±4.0 at the first week, 11.4±3.7 at 1 month, and 13.1±3.6 mm Hg at 3 months postoperatively (Po0.001). There was a significant reduction of the ONH cupping at 1 week (22.3%, Po0.001), 1 month (13.7%, Po0.001), and 3 months (9.8%, P ¼ 0.001) after surgery. Anterior displacement of the LC was slight but statistically significant at 1 week (4.5%, P ¼ 0.003), 1 month (3.8%, P ¼ 0.014), and 3 months postoperatively (3.3%, P ¼ 0.010). IOP reduction was significantly correlated with a reduction of ONH cupping and anterior displacement of LC at the first week and first month (Po0.05). Conclusions Cupping reversal after NPDS is mainly due to changes in prelaminar tissue thickness, whereas the LC changes in position are less pronounced.

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“…9,10 Briefly, the infrared wavelength (870 nm) of the light source results in a roll-off of sensitivity for deeper ONH structures when focused on the internal limiting membrane. Therefore, the focus is shifted to deeper locations, allowing enhanced imaging of deeper structures like the LC.…”

Section: Edi Oct Imagingmentioning

confidence: 99%

“…8 Recently, with advances in enhanced depth imaging (EDI) for spectral domain optical coherence tomography (SD-OCT), it has become feasible to visualize deep ONH structures in glaucoma patients. 9, 10 Raghu et al reported a temporary RNFL thickness increase after trabeculectomy on the basis of time domain OCT findings, with regression to baseline values within 3 months, 11 while recently, Reis et al and Lee et al used SD-OCT images to show an increase in prelaminar tissue thickness and an anterior LC displacement that persisted for 6 months following glaucoma surgery. 6,12 The exact mechanism by which cupping reversal occurs remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Topographic Optic Disc Changes After Successful Trabeculectomy Evaluated Using Spectral Domain Optical Coherence Tomography

Russo

Katsanos

Riva

et al. 2013

Journal of Ocular Pharmacology and Therapeutics

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Purpose: To investigate topographic optic disc changes after surgical intraocular pressure (IOP) reduction in adults with open angle glaucoma (OAG). Methods: Optic discs of patients with advanced primary open angle or exfoliation glaucoma were imaged using optical coherence tomography within 1 week before trabeculectomy. Patients were rescanned 1 week, 1 month, and 1 year after surgery. Maximum cup depth (MCD), and average cup depth (ACD) were calculated. Results: Twenty-two eyes from 20 patients (age, 70.5 -10.6 years; average mean defect of visual field, -15.0 -9.8 dB) were followed up for 1 year. The IOP decreased from 22.1 -2.8 mmHg at baseline to 11.5 -2.6 mmHg 1 year following surgery (P < 0.001). One-week and 1-month postoperative IOPs were 11.2 -2.8 and 11.2 -3.5 mmHg, respectively (P < 0.001). Compared to the baseline values (356 -172 mm), postoperative ACD showed a significant decrease at 1 week (312 -164 mm; P < 0.001) and 1 month (338 -175 mm; P = 0.007) after surgery, but not at 1 year (339 -176 mm; P = 0.354). Similarly, MCD significantly decreased from baseline (477 -190 mm) 1 week (431 -203 mm; P = 0.029) and 1 month (448 -198 mm; P = 0.047) after the surgery, but not after 1 year (479 -188 mm; P = 1.0). Conclusions: Trabeculectomy reduces IOP in eyes with advanced OAG, which induces topographic optic disc changes. Such optic disc changes became less pronounced over time and were no longer detectable 1 year after surgery.

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Visualization of the Lamina Cribrosa Using Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography

Cited by 179 publications

References 31 publications

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Changes in lamina cribrosa and prelaminar tissue after deep sclerectomy

Topographic Optic Disc Changes After Successful Trabeculectomy Evaluated Using Spectral Domain Optical Coherence Tomography

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