Visualization of the electrical activity of the cauda equina using a magnetospinography system in healthy subjects

Ushio, Shuta; Hoshino, Yuko; Kawabata, Shigenori; Adachi, Yoshiaki; Sekihara, Kensuke; Sumiya, Satoshi; Ukegawa, Dai; Sakaki, Kyohei; Watanabe, T.; Hasegawa, Yuki; Okawa, Atsushi

doi:10.1016/j.clinph.2018.11.001

Cited by 26 publications

(7 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 140 Pilot studies have demonstrated that MSG can quantify and visualize electrical conduction through the cervical cord, cauda equina, and peripheral nerves. 141 , 142 It was also demonstrated that MSG identified the site of dorsal column conduction block in one patient with DCM. 141 However, the utility of this technology may be limited by issues of physiological noise and movement, which are minimized in MEG by the closer proximity of the brain to the skin surface and by placing the head in a tight-fitting helmet.…”

Section: Electrophysiology Of the Spinal Cordmentioning

confidence: 95%

Imaging and Electrophysiology for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 9]

Martín

Tetreault

Nouri

et al. 2021

Global Spine Journal

View full text Add to dashboard Cite

Study Design Narrative review. Objective The current review aimed to describe the role of existing techniques and emerging methods of imaging and electrophysiology for the management of degenerative cervical myelopathy (DCM), a common and often progressive condition that causes spinal cord dysfunction and significant morbidity globally. Methods A narrative review was conducted to summarize the existing literature and highlight future directions. Results Anatomical magnetic resonance imaging (MRI) is well established in the literature as the key imaging tool to identify spinal cord compression, disc herniation/bulging, and inbuckling of the ligamentum flavum, thus facilitating surgical planning, while radiographs and computed tomography (CT) provide complimentary information. Electrophysiology techniques are primarily used to rule out competing diagnoses. However, signal change and measures of cord compression on conventional MRI have limited utility to characterize the degree of tissue injury, which may be helpful for diagnosis, prognostication, and repeated assessments to identify deterioration. Early translational studies of quantitative imaging and electrophysiology techniques show potential of these methods to more accurately reflect changes in spinal cord microstructure and function. Conclusion Currently, clinical management of DCM relies heavily on anatomical MRI, with additional contributions from radiographs, CT, and electrophysiology. Novel quantitative assessments of microstructure, perfusion, and function have the potential to transform clinical practice, but require robust validation, automation, and standardization prior to uptake.

show abstract

Section: Electrophysiology Of the Spinal Cordmentioning

confidence: 95%

Imaging and Electrophysiology for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 9]

Martín

Tetreault

Nouri

et al. 2021

Global Spine Journal

View full text Add to dashboard Cite

show abstract

“…Studies have found that evoked electrophysiological activities can be detected though MSG and MNG in various locations along the spinal cord. This indicates the potential of using MSG and MNG as a noninvasive tool for visualizing neural activity in the cauda equina [162], examining lumbar diseases [162], localizing lesion site in the lumbar canal [163], diagnosing conduction block even at the site of spinal stenosis in cervical myelopathy patients [164]- [166], detecting spinal root and dorsal horn dysfunction [166], visualizing ulnar nerve stimulation at spinal tracts at C5/6/7 [167], and measuring neural activity in the dorsal column and dorsal horn in the cervical cord [168] [10]) are examples of evoked MNG and MSG where each spike in the waveform is followed by the applied stimuli. The time difference between the applied stimuli and the appearance of the spike is called the peak latency.…”

Section: Magnetoneurography (Mng) and Magnetospinography (Msg)mentioning

confidence: 87%

A Review of Magnetic Field Emissions From the Human Body: Sources, Sensors, and Uses

Zhu

Kiourti

2022

IEEE Open J. Antennas Propag.

View full text Add to dashboard Cite

It has long been common practice to capture the electric fields emanated by the human body as a means of detecting and/or monitoring diverse health conditions. However, these electric fields are strongly impacted by the complex permittivity of biological tissues which deteriorates their waveforms and limits their diagnostic capabilities. As an alternative, recent progress has been made in the measurement of bio-magnetic fields occur from the natural currents flowing through the body. The advantage in this case is, since tissues are non-magnetic, magnetic fields propagate in an uninterrupted manner towards the skin surface where they are eventually collected. This unveils game-changing opportunities for future medical diagnostics. Nevertheless, a major challenge associated with sensing these naturally emanated magnetic fields is that they are extremely weak, and in fact orders of magnitude smaller than those generated by the Earth. To this end, extensive efforts have been pursued to realize sensing technology that is sensitive enough to collect biomagnetic fields. Example fields of use include magnetomyography (MMG), magnetocardiography (MCG), magnetoencephalography (MEG), and Magnetoneurography (MNG) (including magnetospinography (MSG)). This review will provide an overview of technologies used to sense bio-magnetic fields, list their merits and limits in a critical manner, and discuss clinical applications.INDEX TERMS Bioelectromagnetics, magnetocardiography (MCG), magnetoencephalography (MEG), magnetomyography (MMG), Magnetoneurography (MNG), magnetospinography (MSG).

show abstract

“…These limitations are overcome with magnetospinography (MSG) which uses superconducting quantum interference devices (SQUIDs) to detect the magnetic field generated by the spinal cord [22][23][24][25][26] . The magnetic fields detected with MSG are not as distorted by the tissue surrounding the spinal cord or muscle artefacts, meaning source analysis is more reliable 23,27 .…”

Section: Current Measures Of Spinal Activitymentioning

confidence: 99%

Concurrent spinal and brain imaging with optically pumped magnetometers

Mardell

O'Neill

Tierney

et al. 2022

Preprint

View full text Add to dashboard Cite

The spinal cord and its interactions with the brain are fundamental for movement control and somatosensation. However, brain and spinal cord electrophysiology in humans have largely been treated as distinct enterprises, in part due to the relative inaccessibility of the spinal cord. Consequently, there is a dearth of knowledge on human spinal electrophysiology, including the multiple pathologies of the central nervous system that affect the spinal cord as well as the brain. Here we exploit recent advances in the development of wearable optically pumped magnetometers (OPMs) which can be flexibly arranged to provide coverage of both the spinal cord and the brain concurrently in unconstrained environments. Our system for magnetospinoencephalography (MSEG) measures both spinal and cortical signals simultaneously by employing a custom-made spinal scanning cast. We evidence the utility of such a system by recording simultaneous spinal and cortical evoked responses to median nerve stimulation, demonstrating the novel ability for concurrent non-invasive millisecond imaging of brain and spinal cord.

show abstract

Visualization of the electrical activity of the cauda equina using a magnetospinography system in healthy subjects

Cited by 26 publications

References 45 publications

Imaging and Electrophysiology for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 9]

Imaging and Electrophysiology for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 9]

A Review of Magnetic Field Emissions From the Human Body: Sources, Sensors, and Uses

Concurrent spinal and brain imaging with optically pumped magnetometers

Contact Info

Product

Resources

About