Visualization of Temperature Distribution around Focal Area and Near Fields of High Intensity Focused Ultrasound Using a 3D Measurement System

Iwahashi, Toshihide; Tang, Tianhan; Matsui, Kazuhiro; Fujiwara, Keiichi; Itani, Kazunori; Yoshinaka, Kiyoshi; Azuma, Takashi; Takagi, Shu; Sakuma, Ichiro

doi:10.14326/abe.7.1

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…An older formula, based on the addition of bovine serum albumin (BSA) and pH control, produces a phantom with transition temperature ranging from 50-60 o C [34]. Silicone phantoms have also been made to be thermochromic [35]. Two unusual phantom types have been produced that can indicate temperature ranges rather than a simple binary indication of being above or below the transition temperature, with the material by Iwahashi and colleagues [36] being reversible and that by Kim and colleagues [37] being irreversible.…”

Section: Introductionmentioning

confidence: 99%

Thermochromic Detection of Ultrasound-Induced Nanoparticle Heating in Tissue-Mimicking Solid Gel

Lin

Chen

Huang

2020

Preprint

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Background Microbubble has been extensively used for ultrasound imaging and many other applications such as ultrasound cleaning. Few studies have been reported on ultrasound interactions with small nanoparticles (< 250 nm). Due to the broad use of nanoparticles in many different fields, it is critically important to clarify whether nanoparticles can have strong interaction with ultrasound. In addition, Nanoparticle assisted ultrasound therapy has recently been found to have selective killing of cancer cells compared to normal cells. Nevertheless, the mechanism is not known. The major possible mechanisms for killing cells are cavitation and heating. In this work, a simple thermochromic method is developed to clearly indicate that the interaction of nanoparticle with ultrasound can lead to temperature rise that can lead to selective killing of cancer cells. Results Direct three-dimensional detection of ultrasonically induced heating in a nanoparticle bearing tissue-mimicking gel would provide a means to estimate their effectiveness as thermally-based sonosensitizers. Such a gel was produced through the addition of an irreversible thermochromic liquid to a well-known agarose gel during fabrication. Polystyrene nanoparticles were embedded within gels during production. The placement of gels within a temperature-controlled bath set to a temperature below the transition temperature allows for the visual detection of slight temperature increases. The modified gel material was shown to undergo color change upon heating to 54 °C from blue to white. The appearance of white color on the gel is a clear indication of nanoparticle to enhance the ultrasound energy to increase the temperature of gel. Nanoparticle presence within a solid causing increased heating upon ultrasound exposure, as detected through thermochromicity, is reported for the first time. Conclusion Even small nanoparticles can have significant interaction with ultrasound to lead to temperature rise in the medium. Therefore, the selective killing of cancer cells more than normal cell should be primarily from heating instead of cavitation since cancer cells in general cannot survive in higher temperature than normal cells. Cavitation should lead to the killing of both cancer and normal cells due to the release of a large amount of energy in the process. Direct three-dimensional detection of ultrasonically induced heating in a nanoparticle bearing tissue-mimicking gel becomes feasible.

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Section: Introductionmentioning

confidence: 99%

Thermochromic Detection of Ultrasound-Induced Nanoparticle Heating in Tissue-Mimicking Solid Gel

Lin

Chen

Huang

2020

Preprint

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A visualization method for a wide range of rising temperature induced by high-intensity focused ultrasound using a tissue-mimicking phantom

Takagi

Yoshinaka

Washio

et al. 2021

International Journal of Hyperthermia

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Thermochromic phantoms and paint to characterize and model image-guided thermal ablation and ablation devices: a review

Negussie,

Morhard,

Rivera

et al. 2024

Functional Composite Mater

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Heat-based local ablation techniques are effective treatments for specific oligometastatic and localized cancers and are being studied for their potential to induce immunogenic cell death and augment systemic immune responses to immunotherapies. The diverse technologies associated with thermal therapy have an unmet need for method development to enable device-specific experimentation, optimization, calibration and refinement of the parameter space to optimize therapeutic intent while minimizing side effects or risk to the patient. Quality assurance, training, or comparing thermal dose among different modalities or techniques using animal models is time and resource intensive. Therefore, the application and use of tissue mimicking thermosensitive, thermochromic liquid crystal and thermochromic paint phantom models may reduce costs and hurdles associated with animal use. Further, their homogenous composition may enable more precise assessment of ablative techniques. This review utilized SciFinder, Web of Science, PubMed and EMBASE to systematically evaluate the literature describing the background and applications of thermochromic liquid crystal, thermochromic paint and tissue-mimicking thermochromic phantoms used to characterize the thermal effects of ablation devices with a focus on facilitating their use across the medical device development life cycle. Graphical Abstract

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Visualization of Temperature Distribution around Focal Area and Near Fields of High Intensity Focused Ultrasound Using a 3D Measurement System

Cited by 4 publications

References 10 publications

Thermochromic Detection of Ultrasound-Induced Nanoparticle Heating in Tissue-Mimicking Solid Gel

Thermochromic Detection of Ultrasound-Induced Nanoparticle Heating in Tissue-Mimicking Solid Gel

A visualization method for a wide range of rising temperature induced by high-intensity focused ultrasound using a tissue-mimicking phantom

Thermochromic phantoms and paint to characterize and model image-guided thermal ablation and ablation devices: a review

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