Visualization of pressure distribution within loaded joint cartilage by application of angle-sensitive NMR microscopy

Gründer, Wilfried; Kanowski, Martin; Wagner, M.; Werner, Annett

doi:10.1002/1522-2594(200006)43:6<884::aid-mrm15>3.0.co;2-u

Cited by 78 publications

(89 citation statements)

References 11 publications

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“…1(a), the number of MR visualized zones (multilaminarity) can vary topographically because of the regionally different network structure. Such heterogeneity of cartilage laminae was observed, for instance, within humeral heads of beagles (8,18) and femoral and tibial cartilage of sheep and pigs (10). This is one explanation for the huge discrepancies with respect to the number of laminae observed in MR images.…”

Section: Regional Variation Of Network Structurementioning

confidence: 96%

“…4(a)]. In the trilaminar case, often a small superficial lamina of low intensity, a middle transitional zone of intermediate intensity, and a deep zone of low intensity was observed (8)(9)(10)(11)(12)(19)(20)(21)(22). However, a high/low/high intensity pattern was also observed (23).…”

Section: Age-dependence Of Collageneous Networkmentioning

confidence: 99%

“…In particular, if the surface normal axis is parallel to the static magnetic field, zones of different intensity can be visualized within joint cartilage in T 2 (-weighted) images. Furthermore, the number of zones visualized by MRI varies for different types of joints and joint components and shows regional (site-to-site) (9,10) and age dependencies. These variations reflect different cartilage network structuring resulting from optimal adaptation to the different load-bearing situations.…”

Section: Mri Appearance Of Cartilagementioning

confidence: 99%

“…While there is a strong influence of hydrodynamic effects during fast cyclic compression, in the static case we find a more balanced biomechanical system. Many authors report that MRI visualization changes under pressure (10,(31)(32)(33)(34)(35)(36)(37)(38). It is evident that collagen network structure is influenced by load.…”

Section: Influence Of Load On the Mri Visualization Of Joint Cartilagementioning

confidence: 99%

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MRI assessment of cartilage ultrastructure

Gründer¹

2006

NMR in Biomedicine

121

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In T 2 -weighted MRI images joint cartilage can appear laminated. The multilaminar appearance is visualized as zones of different intensity. This appearance is based on the dipolar interaction of water molecules within cartilage zones of different collageneous network structures. Therefore, the MR visualization of zones of anisotropic arrangement of the collagen fibers depends upon their orientation to the static magnetic field (magic-angle effect). The aim of this article is to demonstrate the potential of high-resolution MRI for characterizing cartilage network structuring and biomechanical properties. Information equivalent to that from polarization light microscopy can be derived noninvasively. Based on NMR microscopic (mMRI) data, potential new possibilities of MRI for quantitative assessment of collagen structuring and intracartilagenous load distribution are presented. These methods use MR intensity angle dependence and load influence on cartilage visualization. Alternatively to the determination of mechanical parameters from cartilage deformation, it is demonstrated that stress distribution and biomechanical properties can be derived in principle from the local intensity variation of anisotropic fiber orientation zones. The limitations with respect to a clinical application of the proposed methods are discussed.

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Section: Regional Variation Of Network Structurementioning

confidence: 96%

Section: Age-dependence Of Collageneous Networkmentioning

confidence: 99%

Section: Mri Appearance Of Cartilagementioning

confidence: 99%

Section: Influence Of Load On the Mri Visualization Of Joint Cartilagementioning

confidence: 99%

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MRI assessment of cartilage ultrastructure

Gründer¹

2006

NMR in Biomedicine

121

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“…Using this effect, it has even become feasible to non-invasively measure pressure distributions in cartilage. 54 . Anisotropic relaxation times of metabolites other than water have not been extensively studied in human skeletal muscle.…”

Section: Effects Of Order Upon Relaxation Times and Signal Decaymentioning

confidence: 99%

Dipolar coupling and ordering effects observed in magnetic resonance spectra of skeletal muscle

Boesch

Kreis

2001

NMR in Biomedicine

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Skeletal muscle is a biological structure with a high degree of organization at different spatial levels. This order influences magnetic resonance (MR) in vivo-in particular 1 H-spectra-by a series of effects that have very distinct physical sources and biomedical applications: (a) bulk fat (extramyocellular lipids, EMCL) along fasciae forms macroscopic plates, changing the susceptibility within these structures compared to the spherical droplets that contain intra-myocellular lipids (IMCL); this effect leads to a separation of the signals from EMCL and IMCL; (b) dipolar coupling effects due to anisotropic motional averaging have been shown for 1 H-resonances of creatine, taurine, and lactate; (c) aromatic protons of carnosine show orientation-dependent effects that can be explained by dipolar coupling, chemical shift anisotropy or by relaxation anisotropy; (d) limited rotational freedom and/or compartmentation may explain differences of 1 H-MR-visibility of the creatine/phosphocreatine resonances; (e) lactate 1 H-MR resonances are reported to reveal information on tissue compartmentation; (f) transverse relaxation of water and metabolites show multiple components, indicative of intra-, extracellular and/or macromolecular-bound pools, and in addition dipolar or J-coupling lead to a modulation of the signal decay, hindering straightforward interpretation; (g) diffusion weighted 31 P-MRS has shown restricted diffusion of phosphocreatine; (h) magnetization transfer (MT) indicates that there is a motionally restricted proton pool in spin-exchange with free creatine; reduced availability or restricted motion of creatine is particularly important for an estimation of ADP from 31 P-MR spectra, and in addition MT effects may alter the signal intensity of creatine 1 H-resonances following water-suppression pulses; (i) transcytolemmal water-exchange can be studied in 1 H-MRS by contrast-agents applied to the extracellular space; (k) transport of glucose across the cell membrane has been studied in diabetes patients using a combination of 13 C-and 31 P-MRS; and (l) residual quadrupolar interaction in 23 Na MR spectra from human skeletal muscle suggest that sodium ions are bound to ordered muscular structures.

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Current Awareness

2000

NMR Biomed.

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Visualization of pressure distribution within loaded joint cartilage by application of angle-sensitive NMR microscopy

Cited by 78 publications

References 11 publications

MRI assessment of cartilage ultrastructure

MRI assessment of cartilage ultrastructure

Dipolar coupling and ordering effects observed in magnetic resonance spectra of skeletal muscle

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