Visualization of Mitochondria During Embryogenesis in Zebrafish by Aggregation-Induced Emission Molecules

Cen, Peili; Cui, Chunyi; Zhong, Yan; Zhou, Youyou; Wang, Zhiming; Xu, Pengfei; Luo, Xiaoyun; Xue, Le; Cheng, Zhen; Wei, Yen; He, Qinggang; Zhang, Hong; Tian, Mei

doi:10.1007/s11307-022-01752-y

Cited by 1 publication

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“…In the past few decades, organic materials have been widely explored in many fields, especially used as fluorescence imaging agents in biological and medical applications. [17][18][19] To solve the main health threat, cancer imaging and theranostics have become a research hotspot in the development of organic dyes that can realize visualization and localization of cancer cells by fluorescence imaging and kill them through different therapies. Organic dyes have displayed great potential and become promising candidates for in vivo cancer imaging and theranostics.…”

Section: Introductionmentioning

confidence: 99%

Aggregation‐induced emission luminogens for in vivo molecular imaging and theranostics in cancer

et al. 2023

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Cancer is one of the most fatal diseases for decades. Aggregation‐induced emission luminogens (AIEgens) have been recently used as molecular imaging or therapeutic agents in cancers, due to the advantages of large Stokes shift, high quantum yield, great biocompatibility, and strong photostability. AIEgens can specifically target different types of cancer via diverse targeting strategies. AIEgen‐based fluorescence imaging, especially near‐infrared imaging, demonstrated deep penetration and suitable signal‐to‐noise ratio, which allows reliable in vivo cancer imaging. Combined with other imaging modalities, AIEgen‐based multimodal imaging could provide multidimensional cancer hallmarks from different perspectives. In addition, AIEgen‐based phototherapy can be used for photodynamic therapy and photothermal therapy, which facilitate ablation of cancer cells with good biosafety and high therapeutic effects in vivo. AIEgens nanoparticles fabricated with some specific chemicals, drugs, or siRNA, could display synergistic therapeutic effects for cancers. This paper comprehensively describes the current status and future perspectives of AIEgens, which have showed a great potential for the future preclinical and clinical translation on in vivo molecular imaging and theranostics in cancer.

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Section: Introductionmentioning

confidence: 99%