Visualization of drug delivery processes using AIEgens

Yuan, Youyong; Liu, Bin

doi:10.1039/c6sc05421h

Cited by 81 publications

(65 citation statements)

References 65 publications

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“…Our group proposed a phenomenon of aggregationinduced emission (AIE), which is exact opposite of the ACQ effect. 26 Because the AIE phenomenon is of academic value and practical implication, many AIE luminogens (AIEgens) have been synthesized and applied in chemosensing, 27 bioprobe, 28 bioimaging, 29 diagnosis and therapy, 30 organic light-emitting diodes 31 and other applications. [32][33][34][35] Recently, our group has developed several AIEgens (Scheme 1) with multicolour emissions, high photostability and biocompatibility for selective lipid droplets imaging.…”

Section: Scheme 1 Molecular Structures Of Aiegens For Lipid Dropletsmentioning

confidence: 99%

Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration

et al. 2018

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Lipid droplets are highly associated with obesity, diabetes, inflammatory disorders and cancer. A reliable two-photon dye for specific lipid droplets imaging in live cells and live tissues at ultra-low concentration has rarely been reported. In this work, four new aggregation-induced emission luminogens (AIEgens) based on the naphthalene core were designed and synthesized for specific two-photon lipid droplets staining. The new molecules, namely NAP AIEgens, exhibit large Stokes shift (>110 nm), high solid-state fluorescence quantum yield (up to 30%), good two-photon absorption cross section (45-100 GM at 860 nm), high biocompatibility and good photostability. They could specifically stain lipid droplets at ultra-low concentration (50 nM) in a short time of 15 min. Such ultra-low concentration is the lowest value for lipid droplets staining in live cells reported so far. In vitro and ex vivo two-photon imaging of lipid droplets in live cells and live mice liver tissues were successfully demonstrated. In addition, selective visualization of lipid droplets in live mice liver tissues could be achieved at a depth of about 70 μm. These excellent properties render them as promising candidates for investigating lipid droplets-associated physiological and pathological processes in live biological samples.

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Section: Scheme 1 Molecular Structures Of Aiegens For Lipid Dropletsmentioning

confidence: 99%

Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration

et al. 2018

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“…As an extensively used clinical method for cancer treatment, CHT is usually performed by interfering with biological processes including DNA replication, transcription and cell division, through many small chemical compounds such as doxorubicin (DOX), camptothecin (CPT), paclitaxel, S-crizotinib, gemcitabine, 7-ethyl-10-hydroxycamptothecin (SN-38) and etoposide. The key to developing contemporary CHT-based theranostic systems is exploiting extraordinary drug delivery systems, aiming to achieve specific delivery of drugs for both enhancing therapeutic effects and evading side effects 88 - 92 , drug distribution monitoring, drug activation monitoring, and therapeutic response monitoring 93 , 94 .…”

Section: Recent Developmentmentioning

confidence: 99%

Theranostics based on AIEgens

Wang

Lee²,

Wei³

et al. 2018

Theranostics

155

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The utilization of luminogens with aggregation-induced emission (AIE) characteristics has recently been developed at a tremendous pace in the area of theranostics, mainly because AIE luminogens (AIEgens) hold various distinct advantages, such as good biocompatibility, excellent fluorescence properties, simple preparation and modification, perfect size of nano-aggregation for enhanced permeability and retention effect, promoted efficiencies of photodynamic and photothermal therapies, efficient photoacoustic imaging, and ready constructions of multimodal imaging and therapy. Significant breakthroughs and developments of theranostics based on AIEgens have been achieved in the past few years, and great progress has been witnessed in many theranostic modalities, indicating that AIEgens remarkably complement conventional theranostic materials and promote the development of theranostics. This review provides theoretical insights into the advantages of AIEgens in theranostics, and systematically summarizes the basic concepts, seminal studies, recent trends and perspectives in theranostics based on AIEgens. We believe that AIEgens would be promising multifunctional theranostic platforms in clinical fields and facilitate significant advancements in this research-active area.

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“…However, in case of the AIEgens, the fluorescence is switched on when they are restricted in nanocarriers due to their unique properties. Therefore, a considerable number of AIEgens were developed to monitor drug release from nanocarriers in situ and obtain information about the biodistribution of delivery systems (Figure ) …”

Section: Applications Of Aie Probes In the Field Of Biological Sciencementioning

confidence: 99%

“…Therefore, a considerable number of AIEgens were developed to monitor drug release from nanocarriers in situ and obtain information about the biodistribution of delivery systems ( Figure 10). 142…”

Section: Tracking Drug Delivery Systemsmentioning

confidence: 99%

A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on

Guo

Song

et al. 2019

Medicinal Research Reviews

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Fluorescence imaging is a promising visualization tool and possesses the advantages of in situ response and facile operation; thus, it is widely exploited for bioassays. However, traditional fluorophores suffer from concentration limits because they are always quenched when they aggregate, which impedes applications, especially for trace analysis and real‐time monitoring. Recently, novel molecules with aggregation‐induced emission (AIE) characteristics were developed to solve the problems encountered when using traditional organic dyes, because these new molecules exhibit weak or even no fluorescence when they are in free movement states but emit intensely upon the restriction of intramolecular motions. Inspired by the excellent performances of AIE molecules, a substantial number of AIE‐based probes have been designed, synthesized, and applied to various fields to fulfill diverse detection tasks. According to numerous experiments, AIE probes are more practical than traditional fluorescent probes, especially when used in bioassays. To bridge bioimaging and materials engineering, this review provides a comprehensive understanding of the development of AIE bioprobes. It begins with a summary of mechanisms of the AIE phenomenon. Then, the strategies to realize accurate detection using AIE probes are discussed. In addition, typical examples of AIE‐active materials applied in diagnosis, treatment, and nanocarrier tracking are presented. In addition, some challenges are put forward to inspire more ideas in the promising field of AIE‐active materials.

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Visualization of drug delivery processes using AIEgens

Abstract: We summarize the recent development of AIEgen based theranostic DDSs for the visualization of drug delivery processes.

Cited by 81 publications

References 65 publications

Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration

Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration

Theranostics based on AIEgens

A new approach to developing diagnostics and therapeutics: Aggregation‐induced emission‐based fluorescence turn‐on

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