Visualization and Quantification of TGF&amp;#946;/BMP/SMAD Signaling under Different Fluid Shear Stress Conditions using Proximity-Ligation-Assay

Mendez, Paul-Lennard; Obendorf, Leon; Knaus, Petra

doi:10.3791/62608

Search citation statements

Order By: Relevance

Paper Sections

Select...

Genomic Regulation By Bmp Signalling1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fluid shear stress (FSS) in vasculature governs vessel de novo formation and remodeling to maintain physiological tissue structure (37). Abnormal patterns of FSS have been shown to enhance TGFβ/ BMP signaling, where low FSS was found to enhance TGFβ/ BMP signaling (38). Furthermore, low FSS enhanced endothelial SMAD1/5 signaling via the BMP9/ALK1 receptor complex that was further enhanced by Endoglin co-receptor.…”

Section: Genomic Regulation By Bmp Signallingmentioning

confidence: 99%

State-of-the-art of the Bone Morphogenetic Protein research field: 13th International BMP Conference, Dubrovnik 2022

Štoković¹,

Ivanjko²,

Jelić³

et al. 2022

Rad Hrvatske akademije znanosti i umjetnosti

View full text Add to dashboard Cite

who got an insight into the latest achievements in basic, translational, and clinical research of BMP molecules through 75 lectures categorized into several scienti c sections. is review paper provides the most important novel ndings on the structure, function, and signaling of BMPs, the role of BMPs in patterning and organoids as well as the role of BMP in metabolism. Moreover, we discussed the role of BMPs in various diseases including cancer pathogenesis, pulmonary arterial hypertension, and brodysplasia ossi cans progressiva (FOP). Finally, we provided an overview of the new BMP-based therapies in regenerative medicine that are currently in di erent stages of preclinical and clinical trials.

show abstract

Section: Genomic Regulation By Bmp Signallingmentioning

confidence: 99%