Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer

Tang, Caoli; Fan, Yongsheng; Yu, Jun; Liu, Cong; Su, Jianmei; Wang, Chunhong

doi:10.7150/jca.47158

Cited by 23 publications

(17 citation statements)

References 82 publications

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“…At the same time, it can regulate the formation of fat and the distribution of lipid in adipose tissue, control the differentiation of adipocytes, and maintain the fat content in vivo (Ravnskjaer et al, 2015). The maladjustment of cAMP signaling pathway may lead to cell metabolic disorders and the occurrence of various diseases (Tang et al, 2021). In our research, a large number of DEGs were significantly enriched in this pathway.…”

Section: Analysis Of Three Metabolic Pathwayssupporting

confidence: 49%

Transcriptome Profiling Based on Larvae at Different Time Points After Hatching Provides a Core Set of Gene Resource for Understanding the Metabolic Mechanisms of the Brood-Care Behavior in Octopus ocellatus

Bao

Liu

et al. 2022

Front. Physiol.

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The metabolic processes of organisms are very complex. Each process is crucial and affects the growth, development, and reproduction of organisms. Metabolism-related mechanisms in Octopus ocellatus behaviors have not been widely studied. Brood-care is a common behavior in most organisms, which can improve the survival rate and constitution of larvae. Octopus ocellatus carried out this behavior, but it was rarely noticed by researchers before. In our study, 3,486 differentially expressed genes (DEGs) were identified based on transcriptome analysis of O. ocellatus. We identify metabolism-related DEGs using GO and KEGG enrichment analyses. Then, we construct protein–protein interaction networks to search the functional relationships between metabolism-related DEGs. Finally, we identified 10 hub genes related to multiple gene functions or involved in multiple signal pathways and verified them using quantitative real-time polymerase chain reaction (qRT-PCR). Protein–protein interaction networks were first used to study the effects of brood-care behavior on metabolism in the process of growing of O. ocellatus larvae, and the results provide us valuable genetic resources for understanding the metabolic processes of invertebrate larvae. The data lay a foundation for further study the brood-care behavior and metabolic mechanisms of invertebrates.

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Section: Analysis Of Three Metabolic Pathwayssupporting

confidence: 49%

Transcriptome Profiling Based on Larvae at Different Time Points After Hatching Provides a Core Set of Gene Resource for Understanding the Metabolic Mechanisms of the Brood-Care Behavior in Octopus ocellatus

Bao

Liu

et al. 2022

Front. Physiol.

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“…Co-cited references not only present the core literature that plays a pivotal role in the evolutionary process within a field, but also unmask the changing trends in research priorities [ 37 ]. Figure 8(a ) presented the network visualization map of the 52 most co-cited references, which was equal or greater than 20 times.…”

Section: Resultsmentioning

confidence: 99%

The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis

Shi

Wei

et al. 2021

Bioengineered

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This study aimed to investigate the distribution laws and research frontiers of international literature, so as to present a holistic bibliometric evaluation of the studies on breast cancer liver metastasis(BCLM). Data were collected from the Web of Science Core Collection database, including publications, year, country, journal, author and keywords. The software VOSviewer and CiteSpace were used for bibliometric coupling, co-authorship, co-citation and co-occurrence analysis. In total, 1,031 publications were analyzed from 2004 to 2020 on BCLM. The year with the highest number of publications was 2006, with 103 papers. The United States, followed by China and Germany were the leading countries on BCLM, accounting for 59% of the whole. The journals that published about BCLM were mainly located in Q1/Q2. Keywords co-occurrence analysis divides BCLM into five clusters:‘basic research’, ‘auxiliary diagnosis and therapy’, ‘liver resection’, ‘clinical trial’ and ‘prognosis’. Main treatment therapies were the latest focus. Burst detection indicated that the trends in BCLM concentrated on subtype and SEER. There is apparently brighter perspective for BCLM research in the coming years, especially in liver resection, subtype and bioinformatics. The consequence of our study as the exclusive scientific evaluation offered an integral overview of BCLM, particularly for research focus and future directions, which can further accurately guide scholars on diagnosis, treatment, and personalized prevention.

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“…It reveals the development status and changes in research in related fields and can be used for frontier analysis, field analysis, and scientific research evaluation. In addition, co-citations can provide advanced support and a theoretical basis for scientific decision-making ( 10 , 22 ). In this study, VOSviewer was used for co-citation analysis to screen out references that were co-cited more than 30 times.…”

Section: Resultsmentioning

confidence: 99%

The global status of research in prostate cancer bone metastasis: A bibliometric and visualized analysis

Wang

Zhu

et al. 2022

Front. Med.

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BackgroundProstate cancer (PCa) is a serious threat to the health of elderly aged groups. It is very important to understand the occurrence and development of PCa for early diagnosis, treatment and metastasis control. This study aims to elucidate the international frontier research direction and literature distribution through bibliometric and visual analyses of PCa bone metastasis.MethodsData were obtained from the Web of Science core collection database, which collected 2,246 papers related to PCa bone metastasis from 1 January 2012 to 31 December 2021. The collected data were analyzed using the VOSviewer software for citation, co-authorship, co-citation, bibliometric coupling, and co-occurrence.ResultsOver the past decade, published papers have increased annually. The United States of America has published 890 papers with 29,161 citations, far more than any other country, and it has the most extensive collaboration with other countries. For example, 33 articles by Saad Fred were cited 2,721 times, and 91 articles from the University of Texas MD Anderson CANC CTR were cited 3,037 times, the most cited author and organization. Peng Xinsheng and Duke UNIV comprise the most active collaborative author and organization, respectively. The most co-cited journal was CANCER RES, with 3,195 citations. Studies of PCa bone metastasis can be divided into four categories: “basic research,” “auxiliary diagnosis and treatment,” “clinical trial,” and “prognosis.”ConclusionOur results provide a comprehensive overview of the research priorities and future directions of PCa bone metastasis, which can further accurately guide researchers in diagnosis, treatment, and personalized prevention.

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Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer

Cited by 23 publications

References 82 publications

Transcriptome Profiling Based on Larvae at Different Time Points After Hatching Provides a Core Set of Gene Resource for Understanding the Metabolic Mechanisms of the Brood-Care Behavior in Octopus ocellatus

Transcriptome Profiling Based on Larvae at Different Time Points After Hatching Provides a Core Set of Gene Resource for Understanding the Metabolic Mechanisms of the Brood-Care Behavior in Octopus ocellatus

The global status of research in breast cancer liver metastasis: a bibliometric and visualized analysis

The global status of research in prostate cancer bone metastasis: A bibliometric and visualized analysis

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