To study the distribution characteristics of the muzzle flow field of the underwater sealed launch in different environments, a two-dimensional axisymmetric multiphase flow numerical model was established. The VOF multiphase flow model, Standard k-ε turbulence model, user-defined function (UDF), and dynamic mesh technology are used to simulate the evolution process of the muzzle flow field of underwater sealed launch and air launch. The calculation results show that the muzzle flow field of the underwater sealed launch is significantly different from that in air. The initial velocity of the projectile for underwater sealed launch is 64 m/s, lower than that in air, while the muzzle pressure and temperature are significantly increased. The Mach disk is initially formed at about 145μs for launched underwater, while it is about 240μs for air launch. When launching underwater, the velocity of the projectile is linear attenuation after it leaves the muzzle, while the projectile first accelerates and then slowly decays launched in air. Compared with launching in air, the core area of the shock wave launched underwater is smaller, the pressure at the warhead is relatively higher, and there is no crown shock wave in front of the projectile head.