Visualization and ablation of the autonomic nervous system corresponding to ganglionated plexi guided by D-SPECT 123I-mIBG imaging in patient with paroxysmal atrial fibrillation

The short‐term impact of the catheter ablation on noninvasive autonomic nervous system parameters in patients with paroxysmal atrial fibrillation

“…Although AFCA has emerged as an effective treatment of AF in selected patients, we should also keep in mind that most unspecified antral PVAI might also affect normal GP function. Whether the change in the ANS is desirable remains to be determined after AFCA in long‐term studies to understand the precision mechanism for individual AF patient to selectively target either vagal or sympathetic nerves during PVAI …”

“…Whether the change in the ANS is desirable remains to be determined after AFCA in long-term studies to understand the precision mechanism for individual AF patient to selectively target either vagal or sympathetic nerves during PVAI. 61…”

“…reported that neither intraprocedural vagal reactions nor increased HR predicted a single procedure clinical outcome . Indeed, the GPs are part of the intrinsic cardiac ANS, including adrenergic and cholinergic nerves, and have the highest densities within 5 mm of the PV‐LA junction indicating that it is difficult to selectively target either vagal or sympathetic nerves during PVAI after AFCA.…”

“…19 Indeed, the GPs are part of the intrinsic cardiac ANS, including adrenergic and cholinergic nerves, and have the highest densities within 5 mm of the PV-LA junction indicating that it is difficult to selectively target either vagal or sympathetic nerves during PVAI. 60,61 Therefore, it could either become proarrhythmic or antiarrhythmic based on which of the two components was going to prevail 3 after AFCA.…”

Evaluation of CZT SPECT imaging for cardiac sympathetic innervation in healthy individuals and patients with atrial fibrillation

“…Due to the high sensitivity of the detectors and the higher spatial resolution, it became possible to obtain qualitative tomographic sections of the heart and to estimate the regional 123 I-mIBG uptake. At the same time, only a few studies have been published in the world literature devoted to the scintigraphic study of violations of sympathetic innervation of the myocardium in patients with heart rhythm disorders and the use of CZT technologies [16,17].…”