Visualising liquid transport through coated pharmaceutical tablets using Terahertz pulsed imaging

Dong, Runqiao; Zeitler, J. Axel

doi:10.1016/j.ijpharm.2022.121703

Cited by 10 publications

(3 citation statements)

References 43 publications

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“…The technique can have a spatial resolution between 50–100

m. Therefore, a non-destructive analysis similar to X-ray tomography is not yet possible [ 82 ]. Nevertheless, it has been demonstrated that on selected tablets, the porosity [ 83 , 84 ] and coating layer thickness can be effectively characterized by this approach [ 85 ]. Optical coherence tomography.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Pharmaceutical Tablets by X-ray Tomography

et al. 2023

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Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry.

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“…The technique can have a spatial resolution between 50–100

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, it has been demonstrated that on selected tablets, the porosity [83,84] and coating layer thickness can be effectively characterized by this approach [85].…”

mentioning

confidence: 99%

Characterization of Pharmaceutical Tablets by X-ray Tomography

et al. 2023

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“…Generally, for immediate release tablets, porosity/pore structure plays a central role in enabling the transport of dissolution liquid in tablets to activate the disintegration process ( Al-Sharabi et al, 2020 ; Dong and Zeitler, 2022 ; Markl et al, 2017a , Markl et al, 2018b , Markl et al, 2020 ; Markl and Zeitler, 2017 ). It has been demonstrated previously that terahertz spectroscopy can be used as a rapid and non-destructive method to measure tablet porosity reliably ( Anuschek et al, 2021 ; Bawuah et al, 2014 , Bawuah et al, 2016 , Bawuah et al, 2020 ; Markl et al, 2017b , Markl et al, 2018a ; Moradikouchi et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%