Visualisierung von Mikrokalzifikationen in digitaler Vollfeldmammographie im Vergleich zu konventioneller Film-Folien-Mammographie

The purpose was to investigate in patients with histologically proven DCIS to what extent there is agreement between radiographically proven microcalcifications of specimens obtained by vacuum-assisted biopsy and the histologic diagnosis of microcalcifications and DCIS, and second, to assess the accuracy of biopsy in relation to the number of specimens obtained in patients with high-grade and low-grade DCIS. Four hundred twenty specimens from 35 patients who were diagnosed with DCIS were examined radiographically and histologically for the presence of microcalcifications. The results were analyzed using the McNemar-test. In addition, the average numbers of biopsy specimens necessary for diagnosing low-grade DCIS and high-grade DCIS were compared using the t-test. Specimen radiography had a PPV of 0.50 and a NPV of 0.85 for the demonstration of DCIS. Differences in localization between radiographically proven microcalcifications and DCIS were statistically significant (p<0.01). The difference between the mean numbers of specimens required per patient for correctly diagnosing high-grade or low-grade DCIS was statistically significant (p<0.01). Specimen radiography is very limited in identifying those specimens that are crucial for diagnosing DCIS. The rate of underestimation is expected to be higher for low-grade than for high-grade DCIS. The findings suggest that all samples obtained by vacuum-assisted breast biopsy should be histologically examined.

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Incorporating new imaging models in breast cancer management

Reddy

Mendelson

2005

Curr. Treat. Options in Oncol.

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Mammography is the only screening test proven to decrease breast cancer morbidity and mortality. Although mammography is an effective screening tool, it does have limitations, particularly in women with dense breasts. New imaging techniques are emerging to overcome these limitations and enhance cancer detection, improving patient outcome. Digital mammography, computer aided detection, breast ultrasound and breast magnetic resonance imaging (MRI) are frequently used adjuncts to mammography in today's clinical practice. Recent studies have shown that these techniques can enhance the radiologist's ability to detect cancer and assess disease extent, which is crucial in treatment planning and staging. Positron emission tomography (PET) also plays an important role in staging breast cancer and monitoring treatment response. Other modalities such as tomosynthesis and MR lymphangiography show promise in overcoming the problems related to dense breast tissue and the lack of noninvasive methods to assess lymph node status. Imaging-guided, minimally invasive therapies are also emerging as alternatives to surgical biopsy for breast lesions. As imaging techniques improve, the role of imaging will continue to evolve with the goal remaining a decrease in breast cancer morbidity and mortality.

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Visualisierung von Mikrokalzifikationen in digitaler Vollfeldmammographie im Vergleich zu konventioneller Film-Folien-Mammographie

Cited by 10 publications

References 10 publications

Digital mammography: what do we and what don’t we know?

Digital mammography: what do we and what don’t we know?

In patients with DCIS: is it sufficient to histologically examine only those tissue specimens that contain microcalcifications?

Incorporating new imaging models in breast cancer management

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