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Muthukrishnan, J; Harikumar, K V S; Jha, Sangeeta; Modi, Kirtikumar D

doi:10.4158/ep.14.5.653

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“…Bone involvement was more severe with brown tumors and pathological fractures in Group A than in Group B, where osteopenic appearance of bones on plain radiographs or normal bones was more frequently seen. [ 3 5 6 ] This was likely due to early diagnosis and improvement in Vit D status in Group B. Children (<18 years) with PHPT presenting with associated Vit D deficiency had severe bone disease, deformities six patients in this series) which only partially recovered after the establishment of cure.…”

Section: Discussionmentioning

confidence: 92%

“…We retrospectively studied 110 consecutive patients with symptomatic PHPT presenting to a tertiary care center in South India during the period January 1994–January 2015 and comparatively studied the characteristics of these cases divided into two groups presenting from January 1994 to May 2007 (161 months), presented in our earlier publication on the subject and later from June 2007 to January 2015 (92 months). [ 3 4 5 6 ] We aimed to see the trends developing in the last two decades in disease profile of PHPT.…”

Section: Discussionmentioning

confidence: 99%

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Primary hyperparathyroidism: Achanging scenario in India

Jha¹,

Muthukrishnan²,

Jha³

et al. 2016

Indian J Endocr Metab

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Introduction:Primary hyperparathyroidism (PHPT) is largely a symptomatic disease with varied systemic manifestations, complicated by coexisting Vitamin D (Vit D) deficiency. Increasing awareness, developments in diagnostics, and Vit D supplementation may have an impact on the disease profile of PHPT.Methods:Clinical, biochemical, and pathological profile of PHPT presenting to a tertiary care center in South India were compared in two groups separated as per the period of presentation (Group A: January 1994–May 2007 - 51 cases and Group B: June 2007–January 2015 - 59 cases).Results:PHPT has remained a disease of female preponderance with similar age of presentation. It is being diagnosed earlier (mean duration of symptoms prior to diagnosis was 38.7 months in Group A, significantly longer than 26 months in Group B). Bone pain and metabolic myopathy were the most common presentations (60%) followed by pathological fracture (16%), renal calculi (13%), and pancreatitis (7%). Pathological fractures have become less frequent. Vit D deficiency is still a widespread co-morbidity. Radionuclide scintigraphy is an effective localizing tool, but ultrasound can be an inexpensive and widely available screening modality.Conclusion:PHPT still remains asymptomatic disease of bones and stones, although it is being diagnosed early. Greater awareness, Vit D supplementation, and better diagnostic tools have made it a disease with lesser morbidity and effective cure.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%