Visual Suppression is Impaired in Spinocerebellar Ataxia Type 6 but Preserved in Benign Paroxysmal Positional Vertigo

Kusumoto, Masahiko; Sakakibara, Ryuji; Yoshida, Tomoe; Yamamoto, Masahiko; Suzuki, Michitaka; Kataoka, Manabu; Tsuyusaki, Yohei; Tateno, Akihiko; Tateno, Fuyuki

doi:10.3390/diagnostics2040052

Cited by 5 publications

(2 citation statements)

References 11 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The loss of visual suppression of nystagmus with optic fixation indicates a lesion at the flocculonodular lobe of the cerebellum ( 38 , 39 ). The effect of visual fixation upon nystagmus was only documented in two patients of the papers reviewed here, with patients with posterior fossa lesions demonstrating a failure of fixation suppression ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Central Positional Nystagmus: A Systematic Literature Review

Macdonald

Kaski²,

Saman

et al. 2017

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveTo provide a systematic review of the clinical and radiological features of lesion-induced central positional nystagmus (CPN) and identify salient characteristics that differentiate central from peripheral positional nystagmus (PN).MethodsSystematic literature search according to the preferred reporting items for systematic reviews and meta-analysis.ResultsA total of 82 patients from 28 studies met the participants intervention, comparison, outcomes, and study designs criteria for inclusion. An atypical direction of nystagmus for the stimulated canal was reported in 97.5% patients during Dix–Hallpike (D–H) and 54.5% upon supine roll testing. Five types of CPNs were identified during positional testing: positional horizontal nystagmus (pHN) (36.8%), positional downbeating nystagmus (pDBN) (29.2%), positional torsional nystagmus (pTN) (2.1%), positional upbeating nystagmus (pUBN) (2.1%), and a combination of the four profiles (29.9%). CPN was paroxysmal (<60 s) in 85% patients on straight head hanging (SHH), 63.9% on D–H, and 37.5% on supine roll, and had a latency <3 s upon positioning in 94.7% patients in which it was reported. Concurrent vertigo was reportedly present in 63.4% patients and 48.8% demonstrated other neurological signs. Radiologically, in 74.4%, there was mention of cerebellar involvement, isolated brainstem involvement in 8.5%, and 14.6% involved the fourth ventricle.ConclusionCurrently, there is a lack of robust data on the clinical and radiological characteristics of CPN highlighting the need for better phenotyping of CPN to help differentiate this entity from peripheral causes of PN. With increased awareness of CPN, particularly in the acute setting, we may see a change in the estimated prevalence of CPN and improved clinical markers to promptly identify the frequently sinister underlying causes.

show abstract

Section: Discussionmentioning

confidence: 99%

Central Positional Nystagmus: A Systematic Literature Review

Macdonald

Kaski²,

Saman

et al. 2017

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…The loss of visual suppression of nystagmus with optic fixation indicates a lesion at the flocculonodular lobe of the cerebellum (38,39). The effect of visual fixation upon nystagmus was only documented in two patients of the papers reviewed here, with patients with posterior fossa lesions demonstrating a failure of fixation suppression (16).…”

Section: Ocular Fixationmentioning

confidence: 99%

Central Positional Nystagmus: A Systematic Literature Review

Kaski

Macdonald

Saman³

et al. 2016

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

Objective: To provide a systematic review of the clinical and radiological features of lesion-induced central positional nystagmus (CPN) and identify salient characteristics that differentiate central from peripheral positional nystagmus (PN).Methods: Systematic literature search according to the preferred reporting items for systematic reviews and meta-analysis.Results: A total of 82 patients from 28 studies met the participants intervention, comparison, outcomes, and study designs criteria for inclusion. An atypical direction of nystagmus for the stimulated canal was reported in 97.5% patients during Dix-Hallpike (D-H) and 54.5% upon supine roll testing. Five types of CPNs were identified during positional testing: positional horizontal nystagmus (pHN) (36.8%), positional downbeating nystagmus (pDBN) (29.2%), positional torsional nystagmus (pTN) (2.1%), positional upbeating nystagmus (pUBN) (2.1%), and a combination of the four profiles (29.9%). CPN was paroxysmal (<60 s) in 85% patients on straight head hanging (SHH), 63.9% on D-H, and 37.5% on supine roll, and had a latency <3 s upon positioning in 94.7% patients in which it was reported. Concurrent vertigo was reportedly present in 63.4% patients and 48.8% demonstrated other neurological signs. Radiologically, in 74.4%, there was mention of cerebellar involvement, isolated brainstem involvement in 8.5%, and 14.6% involved the fourth ventricle. Conclusion:Currently, there is a lack of robust data on the clinical and radiological characteristics of CPN highlighting the need for better phenotyping of CPN to help differentiate this entity from peripheral causes of PN. With increased awareness of CPN, particularly in the acute setting, we may see a change in the estimated prevalence of CPN and improved clinical markers to promptly identify the frequently sinister underlying causes.

show abstract