Visual Side Effects Linked to Sildenafil Consumption: An Update

Ausó, Eva; Gómez‐Vicente, Violeta; Esquiva, Gema

doi:10.3390/biomedicines9030291

Cited by 16 publications

(7 citation statements)

References 112 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Information sought from sources other than health professionals could lead to unexpected consequences that could be directly related to the medication (sildenafil) itself, such as priapism or due to an interaction between sildenafil and other medications the user may take or comorbid conditions he/she may have ( 4 , 5 , 13 – 18 ). The recreational use of sildenafil was also associated with vision changes ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

The Weekend Drug; Recreational Use of Sildenafil Citrate and Concomitant Factors: A Cross-Sectional Study

et al. 2021

View full text Add to dashboard Cite

Background: Men who use erectile dysfunction medications for recreational purposes may be at increased risk of becoming psychologically dependent, which in turn could lead to psychogenic-based erectile dysfunction symptoms. Sildenafil has become one of the most commonly prescribed and abused drugs available today.Objectives: This study aimed to describe the utilization pattern and associated factors of sildenafil citrate among its users visiting community pharmacies in Gondar, Ethiopia.Methods: A facility-based cross-sectional study was conducted from March 20, 2017 to May 10, 2017, among male clients who visited community pharmacies in Gondar town, North West Ethiopia. A self-administered, structured questionnaire was used to collect data from Sildenafil users older than 18 years, that started using the drug (Sildenafil) for at least 6 months before the data collection period. A regression analysis was conducted to determine the association between study variables, and a P-value of <0.05 was considered to declare statistical significance.Results: A total of 65 men participated in the study. Of the total study participants, 33.8% were aged 25–34 years and about 40% of them had multiple sexual partners. The use of sildenafil for recreational purposes was 66.2% and was found to be higher than its use for medical purposes 33.8%. Use of the drug for <1-year duration (AOR = 34.086, 95% CI [2.90, 401.37]) and 2 years duration (AOR = 21.42: 95% CI [2.10, 218.82]) were significantly associated with its use for recreational purpose. Non-recreational use of sildenafil includes erectile problems associated with diabetes mellitus (27.1%), heart disease (9.2%), hyperlipidemia (4.2%), and relationship problems due to stress and poor communication (3.1%).Conclusion: Most men who use sildenafil citrate do so for recreational purposes, and use of sildenafil citrate for 2 years or less was associated with recreational use. There should be a collaborative effort among pharmacists, health professionals, and policymakers to improve the rational use of sildenafil.

show abstract

Section: Discussionmentioning

confidence: 99%

The Weekend Drug; Recreational Use of Sildenafil Citrate and Concomitant Factors: A Cross-Sectional Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Other approaches include nutraceuticals and physical and surgical treatments. Sildenafil has been previously associated with visual impairment and hepatotoxicity, stomach upsets, headaches, and nosebleeds (3)(4)(5). Medicinal plants with aphrodisiac activities have emerged as alternatives to sildenafil attributed to their minimized side effects (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens

Badgal,

Dahiru,

Musa

2023

sciphy

View full text Add to dashboard Cite

This study aimed to explore the phytochemical profile, heavy metal composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens due to its folkloric acclaimed aphrodisiac use. The phytochemicals were quantified gravimetrically while the identification of bioactive compounds was carried out using a combined Gas spectrophotometer-mass spectrophotometer (GC-MS). Heavy metals were quantified using an atomic absorption spectrophotometer while the aphrodisiac and ADMET studies were in silico. The result showed the presence of alkaloids (22.33% ±1.45), saponins (20.17% ±1.88), glycosides (0.55% ±0.03), and flavonoids (32.67% ±1.45), with the absence of steroids and terpenoids. GC-MS analysis identified 25 compounds with linoleic acid having the highest peak area (28.01%) next to palmitic acid (14.08%). Chromium, Cadmium, and Lead were present in concentrations of 0.145 ±0.03, 0.001 ±0.00, and 0.065 ±0.03 ppm respectively. Ethyl D-glucopyranoside had the least BA (-8) and Ki (1.35 µM) docked with human arginase II while Tyrosinol had the least BA (-6.2) and Ki (28.21 µM) docked with phosphodiesterase 5 though both were higher than Sildenafil citrate. All the top docked compounds were predicted to be neither substrates nor inhibitors of P-glycoproteins and cytochrome P450 enzymes without CNS permeability and hepatotoxicity. Conclusively, the present study supports the folkloric aphrodisiac application of Gardenia erubescens, and the heavy metals level was below the acceptable regulatory level, thus, might be safe for occasional use. Additionally, the identified compounds might be considered a novel source of therapeutics against erectile dysfunction.

show abstract

“…Bilateral simultaneous NAION has been reported in several patients [ 7 ]. Up to three weeks after using sildenafil, visual abnormalities have been observed [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Arteritic Anterior Ischemic Optic Neuropathy Associated With the Use of Phosphodiesterase Type 5 Inhibitors: A Literature Review

Hor¹,

Baradeiya²,

Qasim³

et al. 2022

Cureus

View full text Add to dashboard Cite

Phosphodiesterase type 5 (PDE5) inhibitors are frequently used for erectile dysfunction (ED) as the first line of treatment. This medication was initially developed to treat muscle spasms and pulmonary hypertension. The United States Food and Drug Administration (FDA) approved its usage for treating ED. Sildenafil, tadalafil, vardenafil, and avanafil are PDE5 inhibitors. The decrease of cyclic guanosine monophosphate (cGMP) in smooth muscle cells caused by sildenafil causes smooth muscle relaxation and penile erection. Vasodilation of the blood vessels reduces perfusion and blood flow to the optic nerve and eye. Several incidences of non-arteritic anterior ischemic optic neuropathy (NAION) have been recorded in sildenafil users, among other ocular complications. The onset of NAION is usually sudden and painless, and it is associated with any pattern of visual field loss. Possible symptoms include poor visual acuity, diminished color vision, a visual field defect, or hemorrhages in the form of flames. Nevertheless, NAION pathogenesis is still a mystery. Most visual effects are reversible weeks after the medication is stopped, and NAION does not seem to cause a permanent blindness. A small cup-to-disc ratio (disc at risk) and underlying systemic illnesses, such as hypertension, increase the risk of developing NAION. An early indicator of cardiovascular disease is ED. NAION diagnosis is challenging due to a lack of confirmatory diagnostic evidences. Normal visual acuity does not exclude NAION from being a possibility. In order to evaluate visual outcomes in NAION, data on both visual acuity (VA) and the full peripheral visual field are needed. Treatment with steroids did not seem to improve visual results.

show abstract

Visual Side Effects Linked to Sildenafil Consumption: An Update

Cited by 16 publications

References 112 publications

The Weekend Drug; Recreational Use of Sildenafil Citrate and Concomitant Factors: A Cross-Sectional Study

The Weekend Drug; Recreational Use of Sildenafil Citrate and Concomitant Factors: A Cross-Sectional Study

Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens

Non-Arteritic Anterior Ischemic Optic Neuropathy Associated With the Use of Phosphodiesterase Type 5 Inhibitors: A Literature Review

Contact Info

Product

Resources

About