Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.

Miller, Kenneth D.; Chapman, Barbara; Stryker, MP

doi:10.1073/pnas.86.13.5183

Cited by 161 publications

(99 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found, in contrast, that NMDA receptors participate strongly in normal sensory responses in the barn owl's ICx. Similar results have been found in a variety of in vivo preparations, including the striate cortex (Tsumoto et al, 1987;Fox et al, 1989;Miller et al, 1989) somatosensory cortex (Armstrong-James et al, 1993) lateral geniculate nucleus Kwon et al, 1991Kwon et al, , 1992 and ventrobasal thalamus (Salt, 1987;Salt andEaton, 1989, 1991;Eaton and Salt, 1990). Together these data indicate that in many intact preparations, NMDA receptors can participate strongly in normal sensory transmission (for review, see Nelson and Sur, 1992;Daw et al, 1993).…”

Section: Nmda Receptors Mediate Auditory Responses In the Icxsupporting

confidence: 64%

NMDA and non-NMDA glutamate receptors in auditory transmission in the barn owl inferior colliculus

Feldman

Knudsen

1994

J. Neurosci.

View full text Add to dashboard Cite

The pharmacology of auditory responses in the inferior colliculus (IC) of the barn owl was investigated by iontophoresis of excitatory amino acid receptor antagonists into two different functional subdivisions of the IC, the external nucleus (ICx) and the lateral shell of the central nucleus (lateral shell), both of which carry out important computations in the processing of auditory spatial information. Combined application of the NMDA receptor antagonist 2-amino-5-phosphonovaleric acid (AP5) and the non-NMDA receptor antagonist 6-cyano-5-nitroquinoxaline-2,3- dione (CNQX) significantly reduced auditory-evoked spikes at all sites in these two subdivisions, and completely eliminated responses at many locations. This suggests that excitatory amino acid receptors mediate the bulk, if not all, of auditory responses in the ICx and lateral shell. NMDA and non-NMDA receptors contributed differently to auditory responses in the two subdivisions. In the ICx, AP5 significantly reduced the number of auditory-evoked spikes at every site tested. On average, AP5 eliminated 55% of auditory-evoked spikes at multiunit sites and 64% at single-unit sites in this structure. In contrast, in the lateral shell, AP5 significantly reduced responses at less than half the sites tested, and, on average, AP5 eliminated only 19% of spikes at multiunit sites and 25% at single-unit sites. When the magnitude of response blockade produced by AP5 at individual multiunit sites was normalized to adjust for site-to-site differences in the efficacy of iontophoresed AP5 and CNQX, AP5 blockade was still significantly greater in the ICx than the lateral shell. CNQX application strongly reduced responses in both subdivisions. These data suggest that NMDA receptor currents make a major contribution to auditory responses in the ICx, while they make only a small contribution to auditory responses in the lateral shell. Non-NMDA receptor currents, on the other hand, contribute to auditory responses in both subdivisions, and mediate the bulk of auditory transmission in the lateral shell. The time course of the NMDA receptor contribution to ICx auditory responses and the dependence of this contribution on stimulus level were both examined in detail. AP5 preferentially blocked spikes late in ICx auditory responses, while CNQX blocked spikes equally throughout the responses. This pattern is consistent with a simple model in which slow NMDA receptor currents and faster non-NMDA receptor currents are both activated by auditory inputs to ICx neurons.

show abstract

Section: Nmda Receptors Mediate Auditory Responses In the Icxsupporting

confidence: 64%

NMDA and non-NMDA glutamate receptors in auditory transmission in the barn owl inferior colliculus

Feldman

Knudsen

1994

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…An alternative explanation is that NMDARs could play a critical role in action potential generation and that the stimulation pattern is important in determining how much or how little a role. Supporting this idea is the observation that NMDAR antagonists can inhibit cell firing in the visual system (Miller et al, 1989;Sillito et al, 1990;Blitz and Regehr, 2003) (but see Bear et al, 1990) and in the hippocampus, as assessed by population spike size (Abraham and Mason, 1988;Burgard et al, 1989;Dahl et al, 1990). Here, we show that NMDARs do play a critical role in action potential generation in the hippocampal slice and that this role is dependent on stimulation pattern.…”

Section: Introductionsupporting

confidence: 51%

Pattern-Dependent Role of NMDA Receptors in Action Potential Generation: Consequences on Extracellular Signal-Regulated Kinase Activation

Zhao

Adams²,

Dudek³

2005

J. Neurosci.

View full text Add to dashboard Cite

Synaptic long-term potentiation is maintained through gene transcription, but how the nucleus is recruited remains controversial. Activation of extracellular signal-regulated kinases (ERKs) 1 and 2 with synaptic stimulation has been shown to require NMDA receptors (NMDARs), yet stimulation intensities sufficient to recruit action potentials (APs) also appear to be required. This has led us to ask the question of whether NMDARs are necessary for AP generation as they relate to ERK activation. To test this, we examined the effects of NMDAR blockade on APs induced with synaptic stimulation using whole-cell current-clamp recordings from CA1 pyramidal cells in hippocampal slices. NMDAR antagonists were found to potently inhibit APs generated with 5 and 100 Hz synaptic stimulation. Blockade of APs and ERK activation could be overcome with the addition of the GABA A antagonist bicuculline, indicating that APs are sufficient to activate signals such as ERK in the nucleus and throughout the neuron in the continued presence of NMDAR antagonists. Interestingly, no effects of the NMDAR antagonists were observed when theta-burst stimulation (TBS) was used. This resistance to the antagonists is conferred by temporal summation during the bursts. These results clarify findings from a previous study showing that ERK activation induced with TBS is resistant to 2-amino-5-phosphonovalerate, in contrast to that induced with 5 or 100 Hz stimulation, which is sensitive. By showing that NMDAR blockade inhibits AP generation, we demonstrate that a major role that NMDARs play in cell-wide and nuclear ERK activation is through their contribution to action potential generation.

show abstract

“…We found that the initial visual response was very sensitive to CNQX, indicating a strong contribution of AMPA-Rs, in accordance with previous studies (22,31,32). The extent to which NMDA-Rs contribute to the visually driven response is a matter of debate, because some studies reported that APV suppresses visual responses (31,33), whereas other studies found that NMDA-Rs do not contribute strongly to visually driven The data shown here were normalized by the maximum response across conditions in the predrug period. The data from the recovery period were obtained 1 h after the injection.…”

Section: Discussionmentioning

confidence: 99%

Different glutamate receptors convey feedforward and recurrent processing in macaque V1

Self

Kooijmans²,

Supèr³

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

160

179

View full text Add to dashboard Cite

Neurons in the primary visual cortex (V1) receive feedforward input from the thalamus, which shapes receptive-field properties. They additionally receive recurrent inputs via horizontal connections within V1 and feedback from higher visual areas that are thought to be important for conscious visual perception. Here, we investigated what roles different glutamate receptors play in conveying feedforward and recurrent inputs in macaque V1. As a measure of recurrent processing, we used figure-ground modulation (FGM), the increased activity of neurons representing figures compared with background, which depends on feedback from higher areas. We found that feedforward-driven activity was strongly reduced by the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), whereas this drug had no effect on FGM. In contrast, blockers of the NMDA receptor reduced FGM, whereas their effect on visually driven activity varied with the subunit specificity of the drug. The NMDA receptor blocker 2-amino-5-phosphonovalerate (APV) caused a slight reduction of the visual response, whereas ifenprodil, which targets NMDA receptors containing the NMDA receptor NR2B subunit, increased the visual response. These findings demonstrate that glutamate receptors contribute differently to feedforward and recurrent processing in V1 and suggest ways to selectively disrupt recurrent processing so that its role in visual perception can be elucidated.T he areas of the primate visual cortex are arranged in a hierarchy, with feedforward connections propagating information from lower to higher areas and feedback connections carrying information in the opposite direction, back to the lower areas (1). Feedforward and recurrent processing differ greatly in function. Feedforward connections drive neurons in the visual cortex. They shape the receptive field of neurons, causing the rapid formation of tuning properties such as orientation and direction selectivity (2) and even sensitivity to complex objects such as faces. In contrast, recurrent input, carried by feedback connections from higher areas and by horizontal connections within a visual area, is thought not to drive neurons but to mediate modulatory, contextual effects (3, 4). Recurrent connections have been suggested to be involved in attention (5-7), figure-ground segregation (8-11), and conscious visual perception (12, 13), although their precise function is not well understood. One problem in studying the role of recurrent connections has been the lack of a tool to selectively inhibit them without disrupting feedforward processing. Some studies blocked the source of recurrent processing by suppressing activity in higher-level visual areas using cooling or injections of GABA while recording in lower-level areas (9,14,15). The results of these studies vary because some showed strong effects on V1 activity (15) and a decrease in contextual modulation (9), whereas others showed no effect (14). The exact effect of recurrent input into V1, therefore, remains to be elucidated.Why might feed...

show abstract

Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors.

Cited by 161 publications

References 32 publications

NMDA and non-NMDA glutamate receptors in auditory transmission in the barn owl inferior colliculus

NMDA and non-NMDA glutamate receptors in auditory transmission in the barn owl inferior colliculus

Pattern-Dependent Role of NMDA Receptors in Action Potential Generation: Consequences on Extracellular Signal-Regulated Kinase Activation

Different glutamate receptors convey feedforward and recurrent processing in macaque V1

Contact Info

Product

Resources

About