Visual Psychophysics in Head‐Fixed Mice

Krauzlis, Richard J.; Nichols, Nick; Rangarajan, Krsna V.; McAlonan, Kerry; Goldstein, Sheridan; Yochelson, Daniel; Wang, Lupeng

doi:10.1002/cpns.95

Cited by 8 publications

(13 citation statements)

References 35 publications

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“…The behavioral apparatus consisted of a custom-built booth that displayed visual stimuli to the mouse, the updating of the display was coupled to their locomotion. Details of apparatus construction are described elsewhere 64 . The mouse was head-fixed in the center of the apparatus, positioned atop a polystyrene foam wheel (20-cm diameter) that allowed natural walking or running movements along a linear path.…”

Section: Methodsmentioning

confidence: 99%

“…The tasks were similar to those we used previously 13,64 . Experiments were organized in blocks of randomly shuffled, interleaved trials, and each trial consisted of a sequence of epochs that the mouse progressed through by walking or running forwards on the wheel.…”

Section: Methodsmentioning

confidence: 99%

Section: Behavioral Apparatusmentioning

confidence: 99%

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Neuronal modulation in the mouse superior colliculus during covert visual selective attention

Wang

Herman

2021

Preprint

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Covert visual attention is accomplished by a cascade of mechanisms distributed across multiple brain regions. Recent studies in primates suggest a parcellation in which visual cortex is associated with enhanced representations of relevant stimuli, whereas subcortical circuits are associated with selection of visual targets and suppression of distractors. Here we identified how neuronal activity in the superior colliculus (SC) of head-fixed mice is modulated during covert visual attention. We found that spatial cues modulated both firing rate and spike-count correlations, and that the cue-related modulation in firing rate was due to enhancement of activity at the cued spatial location rather than suppression at the uncued location. This modulation improved the neuronal discriminability of visual-change-evoked activity between contralateral and ipsilateral SC neurons. Together, our findings indicate that neurons in the mouse SC contribute to covert visual selective attention by biasing processing in favor of locations expected to contain relevant information.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Neuronal modulation in the mouse superior colliculus during covert visual selective attention

Wang

Herman

2021

Preprint

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“…The behavioral apparatus consisted of a custom-built booth that displayed visual stimuli to the mouse coupled to their locomotion [20]. The mouse was head-fixed in the center of the apparatus, positioned atop a polystyrene foam wheel (20-cm diameter) that allowed natural walking or running movements along a linear path.…”

Section: Behavioral Apparatusmentioning

confidence: 99%

Involvement of Striatal Direct Pathway in Visual Spatial Attention in Mice

Wang

Krauzlis

2020

Current Biology

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“…These robust behavioral responses are highly conserved across species, indicating that the visual field location where stimuli appear conveys valence information and may ultimately be dissected to reveal the circuit mechanisms that mediate response choice to potential threats. On the other hand, recent work has begun to reveal the neural circuit basis of visual stimulus selection to conditioned visual stimuli that predict food or water rewards in head-restrained mice (Krauzlis et al 2020;Lutas et al 2019). However, few studies have quantified the features of novel visual stimuli that cause mice to spontaneously approach.…”

Section: Introductionmentioning

confidence: 99%

Experience-dependent refinement of natural approach responses towards specific visual stimuli in mice

Procacci

Allen

Robb³

et al. 2020

Preprint

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Highlights• Novel stimuli with specific visual features reliably elicit an approach in C57BL/6J mice.• Introduction of motion to stimuli makes freezing the most probable behavioral response.• Spontaneous behavioral responses are tuned to size, speed and visual field location.• Prey capture experience selectively refines natural, visually-evoked approach behaviors. AbstractSpecific features of visual objects innately draw orienting and approach responses in animals, and provide natural signals of potential reward. In addition, the rapid refinement of innate approach responses enhances the ability of an animal to effectively and conditionally forage, capture prey or initiate a rewarding social experience. However, the neural mechanisms underlying how the brain encodes naturally appetitive stimuli and conditionally transforms stimuli into approach behavior remain unclear. As a first step towards this goal, we have developed a behavioral assay to quantify innate, visually-evoked approach behaviors in freely moving mice presented with simple, computer generated stimuli of varying sizes and speeds in the lower visual field. We found that specific combinations of stimulus features selectively evoked innate approach versus freezing behavioral responses. Surprisingly, we also discovered that prey capture experience selectively modified a range of visually-guided appetitive behaviors, including increasing the probability of approach and pursuit of moving stimuli, as well as altering those visual features that evoked approach. These findings will enable the use of sophisticated genetic strategies to uncover novel neural mechanisms underlying predictive coding, innate behavioral choice, and flexible, state-dependent processing of stimuli in the mouse visual system.

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Visual Psychophysics in Head‐Fixed Mice

Cited by 8 publications

References 35 publications

Neuronal modulation in the mouse superior colliculus during covert visual selective attention

Neuronal modulation in the mouse superior colliculus during covert visual selective attention

Involvement of Striatal Direct Pathway in Visual Spatial Attention in Mice

Experience-dependent refinement of natural approach responses towards specific visual stimuli in mice

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