Visual perception and hand function in persons with multiple sclerosis

Lau, Andy T. Y.; Chan, Chi Chiu; Keung, Yuen Hon

doi:10.1002/oti.75

Cited by 7 publications

(4 citation statements)

References 23 publications

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“…Many aspects of visual perception have been shown to be affected in adult MS, including visual form perception, 44 facial perception, 45 and visual-spatial perception. 46 As noted above, many other functions can also affect visual-spatial abilities, including motor and executive abilities, which are also commonly impaired in MS. 47 Thus, effects of MS on visual-spatial abilities are difficult to isolate from other areas of functioning and must be interpreted cautiously.…”

Section: Neuropsychology Of Pediatric and Adult Msmentioning

confidence: 99%

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Neuropsychological correlates of multiple sclerosis across the lifespan

et al. 2015

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Neurobiology of pediatric and adult MSThe few pathological studies of pediatric MS suggest that it shares many features with the adult disease. As in adult MS, myelin and axonal damage have also been found in normal-appearing intrahemispheric, interhemispheric, and projection white matter tracts. 9 Despite some remyelination after an attack, over time neurological functioning is permanently decreased due to irreversible axonal injury, depletion of oligodendrocytes, and gliosis. 10 Notably, a recent study has suggested that the extent of acute axonal damage in early active demyelinating lesions is increased by 50% in pediatric patients as compared to adults. 11 This finding may provide some explanation for the often observed severe onset in pediatric MS. Neuropsychological correlates of multiple sclerosis across the lifespanJulia Nunan-Saah, Selvi R Paulraj, Emmanuelle Waubant, Lauren B Krupp and Rowena G Gomez Abstract: Multiple sclerosis can adversely affect cognitive functioning whether the disease has an adult or pediatric onset. The research thus far suggests that pediatric MS shares many features with adult MS but is also unique in several respects. One particular characteristic of pediatric MS is that, while physical disability develops more slowly as compared with adult patients, the impact of cognitive deficits in children may be more substantial as they are in a period of life during which they acquire many skills that are needed to transition into independently functioning adults. Our review takes a lifespan approach to MS, comparing and contrasting the neuropsychology (i.e., cognitive, psychological, and psychosocial factors) of these two populations. Understanding how MS manifests across the lifespan has important implications for tailoring assessment and treatment for individuals with MS as they transition from childhood to adulthood, and later life.

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Section: Neuropsychology Of Pediatric and Adult Msmentioning

confidence: 99%

“…46 As noted above, many other functions can also affect visual-spatial abilities, including motor and executive abilities, which are also commonly impaired in MS. 47 Thus, effects of MS on visual-spatial abilities are difficult to isolate from other areas of functioning and must be interpreted cautiously.…”

Section: Cognitive Factors Affected By Msmentioning

confidence: 99%

Neuropsychological correlates of multiple sclerosis across the lifespan

et al. 2015

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“…There was also considerable difficulty in classifying many of the measures due to the lack of information given in the papers, and this may have had an impact on the frequency of the classes and batteries. Both visual acuity and motor dexterity can be impaired in MS (Lau et al, 1998), and cognitive assessments often involve the visual processing of stimuli, with participants giving motor (for example, written) or verbal responses. The written administrations of assessments can be affected by manual dexterity issues in MS, and while the verbal administrations are often used to overcome this, such as the oral administration of the SDMT, studies often did not specify this.…”

Section: Discussionmentioning

confidence: 99%

Cognitive measures used in adults with multiple sclerosis: A systematic review

Elwick

Topcu

Allen

et al. 2021

Neuropsychological Rehabilitation

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Cognitive problems are common in people with Multiple Sclerosis (MS), and researchers and clinicians have used a vast array of measures to assess cognition. Our aim was to systematically identify cognitive measures routinely used in MS research, and outline their different uses. Previous recommendations of cognitive measures to use in MS have relied on expert consensus approaches. We believe this systematic review is a starting point for an evidence-based approach to recommending cognitive tests for use with people with MS.We systematically searched electronic databases using relevant search terms for studies that assessed cognitive functioning in MS (last search in February 2020). From 11,854 abstracts retrieved, based on title and abstract review, 2,563 remained. Data were extracted from 1,526 studies.Studies used 5,665 measures of cognition, with 316,053 people with MS. Substitutional style tests, serial addition tests, and word list learning tests were the most commonly used individual tests, and the Brief Repeatable Battery of Neuropsychological Tests was the most commonly used battery. Some of the most frequently used measures were potentially inappropriate due to measuring irrelevant domains of cognition, and issues with sensitivity. Further research is needed to ascertain the psychometric properties, and acceptability of measures for people with MS.

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“…Acute unilateral optic neuritis is one of the most prevalent presenting symptoms of MS (Costello, 2013), and many individuals continue to have persistent visual impairment after optic neuritis is resolved (Jasse et al, 2013). Upper and lower extremity weakness and ataxia are also prevalent among pwMS (Benedict et al, 2011;Lau et al, 1998). Visual and motor impairment may interfere with validity of neuropsychological tests.…”

Section: Sensory Confoundsmentioning

confidence: 99%