Visual mismatch negativity among patients with schizophrenia

Urban, Aleš; Kremláček, Jan; Masopust, J; Libiger, Jan

doi:10.1016/j.schres.2008.03.014

Cited by 55 publications

(64 citation statements)

References 33 publications

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“…The authors did not find any relationship between patient's deviance detection activity and age, illness duration, equivalent dose medication, and their functional status. While the impairment of an early deviance processing resembles results reported by Urban et al (2008), the absence of any relationship to the clinical markers does not. The reason of such discrepancy may lay in different patient groups.…”

Section: Schizophreniasupporting

confidence: 44%

“…Regarding studies on substance abuse, while a longer methamphetamine abuse or a higher antipsychotic dose (Urban et al, 2008) corresponded to a lower vMMN amplitude, the level of alcohol consumption did not . However, these results should not be taken as a sign of inconsistency, because an acute intoxication was considered in case of the alcohol study and a long term effect of use/abuse was followed in the other two studies.…”

Section: Correlations Between Vmmn and Clinical Indicesmentioning

confidence: 89%

“…The remaining studies analyzed vMMN amplitude. Smaller visual mismatch responses were linked to more severe negative symptoms (Urban et al, 2008), and more positive vMM was associated with better facial emotion recognition skills in schizophrenia. In a study focusing on healthy adults more negative vMMN amplitude was associated with lower AQ (Gayle et al, 2012), however, in some subjects with a higher AQ the mismatch response was in the positive range.…”

Section: Correlations Between Vmmn and Clinical Indicesmentioning

confidence: 93%

“…More recent research has focused on the corresponding paradigm in the visual domain using the visual MMN Farkas, Stefanics, Marosi, & Csukly, 2015;Urban, Kremlacek, Masopust, & Libiger, 2008). According to an increasingly popular interpretation, the auditory and visual MMN represent a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals (Friston, 2010;Stefanics et al, 2014).…”

Section: Schizophreniamentioning

confidence: 99%

“…In the first vMMN report in schizophrenia, Urban et al (2008) used motion-onset stimuli in the visual periphery while subjects attended to a motion-detection task in the central visual field. The authors reported a smaller vMMN to changes in motion direction in patients with schizophrenia (for details see Table 1) than in age-and gender-matched controls.…”

Section: Schizophreniamentioning

confidence: 99%

See 4 more Smart Citations

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

113

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The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensor...

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Section: Schizophreniasupporting

confidence: 44%

Section: Correlations Between Vmmn and Clinical Indicesmentioning

confidence: 89%