Visual improvement during psychophysical training in an adult amblyopic eye following visual loss in the contralateral eye

Fronius, Maria; Cirina, Licia; Cordey, Angelika; Ohrloff, C.

doi:10.1007/s00417-004-1014-8

Cited by 33 publications

(26 citation statements)

References 10 publications

(15 reference statements)

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“…A number of clinical studies suggest that some recovery from amblyopia is possible well past the classically defined critical period in humans, which generally is considered to last up to ϳ9 years of age (Birnbaum et al, 1977;Simmers and Gray, 1999;Fronius et al, 2004). These studies indicate that long periods of depriving the dominant eye in amblyopes are needed for recovery of vision in the weak eye.…”

Section: Discussionmentioning

confidence: 99%

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

Yashiro¹,

Corlew²,

Philpot

2005

J. Neurosci.

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Use-dependent modifications of synapses have been well described in the developing visual cortex, but the ability for experience to modify synapses in the adult visual cortex is poorly understood. We found that 10 d of late-onset visual deprivation modifies both presynaptic and postsynaptic elements at the layer 432/3 connection in the visual cortex of adult mice, and these changes differ from those observed in juveniles. Although visual deprivation in juvenile mice modifies the subunit composition and increases the current duration of synaptic NMDA receptors (NMDARs), no such effect is observed at synapses between layer 4 and layer 2/3 pyramidal neurons in adult mice. Surprisingly, visual deprivation in adult mice enhances the temporal summation of NMDAR-mediated currents induced by bursts of high-frequency stimulation. The enhanced temporal summation of NMDAR-mediated currents in deprived cortex could not be explained by a reduction in the rate of synaptic depression, because our data indicate that late-onset visual deprivation actually increases the rate of synaptic depression. Biochemical and electrophysiological evidence instead suggest that the enhanced temporal summation in adult mice could be accounted for by a change in the molecular composition of NMDARs at perisynaptic/extrasynaptic sites. Our data demonstrate that the experience-dependent modifications observed in the adult visual cortex are different from those observed during development. These differences may help to explain the unique consequences of sensory deprivation on plasticity in the developing versus mature cortex.

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Section: Discussionmentioning

confidence: 99%

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

Yashiro¹,

Corlew²,

Philpot

2005

J. Neurosci.

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“…The neurosciences had suggested earlier a limitation of the sensitive period up to about 6 years ( [3], extrapolated from animal work, e.g. [4]); more recently, the period of susceptibility to change after enforced use of the amblyopic eye has been extended into adulthood [5][6][7][8]. Accordingly, the recommendations for age limits vary, e.g.…”

Section: Introductionmentioning

confidence: 99%

Electronic monitoring of occlusion treatment for amblyopia in patients aged 7 to 16 years

Fronius

Bachert

Lüchtenberg

2009

Graefes Arch Clin Exp Ophthalmol

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This study presents for the first time objective treatment and dose response data in amblyopic patients beyond the "classical" treatment age. Electronic monitoring of occlusion and considerable amounts of patching were shown to be feasible. The acuity results indicate that there is a potential for improvement, yet treatment seemed to be less efficient than shown by previous studies in younger patients. Continuation of this research may advance the discussion about age-dependent evidence-based amblyopia treatment, about preschool screening for amblyopia and about plasticity of the visual system.

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“…It has been reported that the visual acuity of the amblyopic eye can display partial spontaneous recovery following loss of vision in the fellow eye [105][106][107][108][109], but the occurrence of this fortunate response is unpredictable and which factors promote improvement under similar circumstances remains totally unknown. We recently addressed the possibility to rescue visual acuity in long-term deprived adult rats exposed to EE immediately after silencing of retino-thalamic projections of the fellow (non amblyopic) eye due to optic nerve dissection [110].…”

Section: Amblyopia Recovery In Enriched Animalsmentioning

confidence: 99%

Environmental Influences on Visual Cortex Development and Plasticity

Sale¹,

Berardi²,

Maffei³

2012

Visual Cortex - Current Status and Perspectives

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Visual improvement during psychophysical training in an adult amblyopic eye following visual loss in the contralateral eye

Cited by 33 publications

References 10 publications

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex

Electronic monitoring of occlusion treatment for amblyopia in patients aged 7 to 16 years

Environmental Influences on Visual Cortex Development and Plasticity

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