Visual impairment induced by prosthetic cobaltism

Sánchez-Dalmau, Bernardo; Spencer, Felipe; Sánchez-Vela, Laura; Camós-Carreras, Anna; Xarau, Santiago Nogué; Fernández-Valencia, Jenaro Á.

doi:10.1016/j.oftale.2020.06.025

Cited by 3 publications

(1 citation statement)

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“…3,6 The clinical manifestation of cobalt intoxication includes various symptoms, such as skin reactions, hypothyroidism, testicular atrophy, and CNS toxicity, including vision and hearing impairment at higher concentrations as well as reversible but rapidly progressive cardiomyopathy with a high short-term mortality. 5,[7][8][9][10][11][12] In addition, possible cancer development, 13,14 and autoimmune, haematological and infectious diseases 15 were associated with high cobalt levels. The inhalation of cobalt-containing dust was related to occupational asthma, heavy metal pneumoconiosis, pulmonary brosis, and the aforementioned cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes

Moravcová,

Lomozová,

Kučera

et al. 2023

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes

Moravcová,

Lomozová,

Kučera

et al. 2023

RSC Adv.

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Systemic Cobalt Toxicity Secondary to Metal-on-Metal Prosthetic Hip Replacement: a Case Report

Blackmon,

Goode

et al. 2023

J GEN INTERN MED

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A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators

Moravcová

Hrubša

Lomozová

et al. 2023

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Background:: Cobalt is an essential trace element, but it can also rarely cause cobalt toxicity due to its release from cobalt-containing medical devices. Currently, there are no approved selective cobalt chelators which would represent an optimal treatment modality. Objective:: This study aimed to develop a simple and complex methodological approach for screening potential cobalt chelators along with evaluating their potential toxicity. Methods:: Firstly, a simple spectrophotometric assay employing 1-nitroso-2-naphthol-3,6- disulfonic acid disodium salt (NNDSA) for screening cobalt chelation was standardized at a pathophysiologically relevant range of pH 4.5-7.5. Then, the suitability of the method was verified using four known metal chelators (EDTA, 8-hydroxyquinoline, chloroxine and nitroxoline). As cobalt can catalyse the Fenton reaction, the potential toxicity of cobalt-chelator complexes was also determined by employing a novel HPLC method with coulometric detection. The effect on erythrocyte haemolysis was tested as well. Results:: The NNDSA method had high sensitivity enabling the detection of 25-200 nM of cobalt ions depending on pH conditions. Measurements could be carried out on a wide range of wavelengths from 470 to 540 nm. All tested complexes of the selected chelators decreased the rate of the Fenton reaction. Interestingly, chloroxine mixed with cobalt ions caused a marked lysis of erythrocytes in contrast to the other compounds. Conclusion:: The described complex methodological approach could serve as a simple, yet precise tool for making an evaluation of novel, effective and safe cobalt chelators.

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Visual impairment induced by prosthetic cobaltism

Cited by 3 publications

References 10 publications

3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes

3-Hydroxyflavone is a mildly active and safe cobalt chelator while cobalt markedly enhances baicalein toxicity toward erythrocytes

Systemic Cobalt Toxicity Secondary to Metal-on-Metal Prosthetic Hip Replacement: a Case Report

A Complex Methodological Approach for the Screening of Efficient and Safe Cobalt Chelators

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