Visual functions affecting stereopsis in patients with branch retinal vein occlusion

Morikawa, Shohei; Okamoto, Fumiki; Murakami, Tomoya; Sugiura, Yoshimi; Hiraoka, Takahiro; Oshika, Tetsuro

doi:10.1038/s41433-021-01452-x

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…The literature suggests a potential correlation between metamorphopsia and stereopsis, although definitive conclusions remain elusive. 17,20,29,30 Piano et al 30 reported a quantitative correlation between the severity of perceptual visual distortions and poorer stereopsis among amblyopic subjects, using Frisby or preschool Randot stereotests. Similarly, research has often highlighted the co-occurrence of metamorphopsia and reduced stereopsis in retinal diseases.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, studies on MH and branch retinal vein occlusion patients, along with additional research on ERM surgeries, did not find a significant correlation between metamorphopsia severity and stereoacuity. 17,29,32 The stereotests employed in these studies primarily focused on near vision, lacking assessments for distance stereopsis. Our research contributes quantitative evidence supporting the correlation between metamorphopsia and stereopsis impairment across both near and distance vision, indicating that metamorphopsia significantly impacts the ability for depth perception.…”

Section: Discussionmentioning

confidence: 99%

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Quantifying the Relationship Between Unilateral Induced Metamorphopsia and Stereopsis Impairment

Xu,

Liu,

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.To investigate the relationship between unilateral metamorphopsia, characterized by visual distortions in one eye, and impaired stereopsis. METHODS.Utilizing both near and distance measurements through advanced testing systems, including 4K smartphones and an active shutter three-dimensional system, we simulated varying degrees of unilateral metamorphopsia in 30 healthy young adults aged between 21 and 29 years. Two types of contour-based stereotest symbols, lines and squares, were developed. Distortions were classified into six distinct patterns, each further divided into eight grades of severity. Participants were tasked with identifying visual targets, and their stereothresholds were determined under different conditions of induced distortion. Stereopsis was measured within a range of 2.9 to 1.0 log arcsec, at 0.2 log arcsec intervals. Stereopsis changes under different distortion scenarios were analyzed using the generalized estimating equations, with a sequential Bonferroni adjustment applied for pairwise comparisons. RESULTS.A direct and quantifiable correlation was observed between the severity of metamorphopsia and reductions in stereopsis. As the degree of visual distortion increased, notably in both frequency and amplitude, there was a corresponding decline in stereopsis. This relationship held true in both near and distance measurements of stereopsis. Statistical analyses further reinforced these findings, highlighting a significant detrimental effect of distortion components on stereoacuity. CONCLUSIONS.The findings highlight the clinical significance of understanding the interplay between unilateral metamorphopsia and stereopsis. Early interventions in conditions leading to metamorphopsia might be critical to maintaining optimal stereopsis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quantifying the Relationship Between Unilateral Induced Metamorphopsia and Stereopsis Impairment

Xu,

Liu,

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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“…Stereopsis is the most advanced visual function that enables depth of field recognition based on the image disparity formed by the two eyes. Stereopsis was found to be impaired, affecting quality of life, in patients with unilateral retinal diseases, including MH [4][5][6][7], epiretinal membrane [12,13], and branch retinal vein occlusion [14][15][16]. In addition, stereopsis in MH was associated with retinal microstructure, including defect length of the external limiting membrane (ELM) and interdigitation zone [5,6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of stereopsis and foveal microstructure after internal limiting membrane peeling and inverted internal limiting membrane flap techniques in patients with macular hole

Morikawa,

Okamoto,

Murakami

et al. 2024

PLoS ONE

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Purpose To compare stereopsis and foveal microstructure after internal limiting membrane peeling and inverted internal limiting membrane flap technique in patients with macular hole. Design Retrospective observational study. Methods Sixty-six patients with macular hole were included, of whom 41 underwent 25-gauge pars-plana vitrectomy with complete internal limiting membrane peeling (Peeling group) and 25 with the inverted flap technique (Inverted group). We evaluated stereopsis using the Titmus Stereo Test and the TNO stereo test, best-corrected visual acuity, macular hole closure rate, and foveal microstructure with optical coherence tomography before and at 3, 6, and 12 months after surgery. Main outcome measures Stereopsis and foveal microstructure. Results Preoperatively, no difference was observed in the base and minimum diameters of macular hole, Titmus Stereo Test score, TNO stereo test score, and best-corrected visual acuity between the Peeling and Inverted groups. The macular hole closure rate in the Peeling and Inverted groups were 97.6% and 100%, respectively, with no significant difference between groups. At 12 months postoperatively, Titmus Stereo Test score (2.1 ± 0.4 in the peeling and 2.2 ± 0.4 in the inverted groups), TNO stereo test score (2.3 ± 0.4 and 2.2± 0.5), and best-corrected visual acuity (0.20 ± 0.18 and 0.24 ± 0.25) were not significantly different between groups (p = 0.596, 0.332, respectively). The defect of the external limiting membrane was more common in the Inverted group than in the Peeling group at 6 months after surgery (5.4 vs. 28.0%; p < 0.05). No statistically significant inter-group differences were noted in the ellipsoid zone defect ratio throughout the follow-up period. Conclusions There was no difference in postoperative stereopsis nor foveal microstructure between the internal limiting membrane peeling group and the inverted group in patients with macular hole.

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“…Branch retinal vein occlusion (BRVO) is the second most common retinal circulatory disease, and causes the retinal edema, hemorrhage, and/or ischemia in the affected area [1,2]; involvement of the macular area in these pathological indications results in signi cant vision impairments [3][4][5]. Anti-vascular endothelial growth factor (VEGF) therapy can be used to treat most macular edemas (MEs) [6][7][8][9][10], and this has led to substantial improvements in the clinical management of decreased visual acuity (VA) [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Binocular Metamorphopsia in Patients with Branch Retinal Vein Occlusion: A Multi- Center Study

Osaka

Muraoka

Nagasato

et al. 2022

Preprint

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Purpose: The pathology of branch retinal vein occlusion (BRVO), a retinal circulatory disease, is related to monocular metamorphopsia-related vision impairment of the affected eyes, but the association of binocular metamorphopsia in such patients is unclear. This study aimed to examine the frequency of binocular metamorphopsia and its association with the clinical characteristics of patients with BRVO. Methods: A total of 99 patients who were treated for BRVO-associated macular edema (ME) were included in this study. At baseline and 1 and 3 months after the initiation of anti-vascular endothelial growth factor (VEGF) treatment, we quantified metamorphopsia in the affected eyes and binocular metamorphopsia using the M-CHARTS® diagnostic tool. Results: At baseline, 59 and 10 patients had metamorphopsia in the affected eyes and binocular metamorphopsia, respectively. Although the visual acuity improved significantly after the initiation of anti-VEGF treatment, the mean M-CHARTS score in the affected eyes did not change from the baseline score. At 3 months, 13 patients showed binocular metamorphopsia; it was significantly associated with metamorphopsia in the affected eyes with a 95% confidence interval of 0.037–0.172 (β = 0.305, p = 0.003). Conclusion: Metamorphopsia in the affected eyes can cause binocular metamorphopsia in patients with BRVO-ME.

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Visual functions affecting stereopsis in patients with branch retinal vein occlusion

Cited by 5 publications

References 33 publications

Quantifying the Relationship Between Unilateral Induced Metamorphopsia and Stereopsis Impairment

Quantifying the Relationship Between Unilateral Induced Metamorphopsia and Stereopsis Impairment

Comparison of stereopsis and foveal microstructure after internal limiting membrane peeling and inverted internal limiting membrane flap techniques in patients with macular hole

Binocular Metamorphopsia in Patients with Branch Retinal Vein Occlusion: A Multi- Center Study

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